Détail - canceropole-wordpress

Alteration of the Neuromuscular Junction and Modifications of Muscle Metabolism in Response to Neuron-Restricted Expression of the CHMP2B Mutant in a Mouse Model of ALS-FTD Syndrome.

Waegaert R, Dirrig-Grosch S, Liu H, Boutry M, Luan P, Loeffler JP, René F

Biomolecules. 2022 Mar 24;12(4):

Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles.

Le Gall L, Duddy WJ, Martinat C, Mariot V, Connolly O, Milla V, Anakor E, Ouandaogo ZG, Millecamps S, Lainé J, Vijayakumar UG, Knoblach S, Raoul C, Lucas O, Loeffler JP, Bede P, Behin A, Blasco H, Bruneteau G, Del Mar Amador M, Devos D, Henriques A, Hesters A, Lacomblez L, Laforet P, Langlet T, Leblanc P, Le Forestier N, Maisonobe T, Meininger V, Robelin L, Salachas F, Stojkovic T, Querin G, Dumonceaux J, Butler Browne G, González De Aguilar JL, Duguez S, Pradat PF

J Cachexia Sarcopenia Muscle. 2022 Feb 22;:

Repurposing of Trimetazidine for Amyotrophic Lateral Sclerosis: a study in SOD1 mice.

Scaricamazza S, Salvatori I, Amadio S, Nesci V, Torcinaro A, Giacovazzo G, Primiano A, Gloriani M, Candelise N, Pieroni L, Loeffler JP, Renè F, Quessada C, Tefera TW, Wang H, Steyn FJ, Ngo ST, Dobrowolny G, Lepore E, Urbani A, Musarò A, Volonté C, Ferraro E, Coccurello R, Valle C, Ferri A

Br J Pharmacol. 2021 Nov 16;:

Skeletal Muscle Metabolism: Origin or Prognostic Factor for Amyotrophic Lateral Sclerosis (ALS) Development?

Quessada C, Bouscary A, René F, Valle C, Ferri A, Ngo ST, Loeffler JP

Cells. 2021 Jun 9;10(6):

Drug repositioning in neurodegeneration: An overview of the use of ambroxol in neurodegenerative diseases.

Bouscary A, Quessada C, René F, Spedding M, Henriques A, Ngo S, Loeffler JP

Eur. J. Pharmacol.. 2020 Jul 30;:173446

Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1 Mice Predates Disease Onset and Is A Promising Therapeutic Target.

Scaricamazza S, Salvatori I, Giacovazzo G, Loeffler JP, Renè F, Rosina M, Quessada C, Proietti D, Heil C, Rossi S, Battistini S, Giannini F, Volpi N, Steyn FJ, Ngo ST, Ferraro E, Madaro L, Coccurello R, Valle C, Ferri A

iScience. 2020 Apr 21;23(5):101087

Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis.

Steyn FJ, Li R, Kirk SE, Tefera TW, Xie TY, Tracey TJ, Kelk D, Wimberger E, Garton FC, Roberts L, Chapman SE, Coombes JS, Leevy WM, Ferri A, Valle C, René F, Loeffler JP, McCombe PA, Henderson RD, Ngo ST

Brain Commun. 2020 ;2(2):fcaa154

Longitudinal transcriptomic analysis of altered pathways in a CHMP2B-based model of ALS-FTD.

Waegaert R, Dirrig-Grosch S, Parisot F, Keime C, Henriques A, Loeffler JP, René F

Neurobiol. Dis.. 2019 Dec 16;136:104710

Ambroxol Hydrochloride Improves Motor Functions and Extends Survival in a Mouse Model of Familial Amyotrophic Lateral Sclerosis.

Bouscary A, Quessada C, Mosbach A, Callizot N, Spedding M, Loeffler JP, Henriques A

Front Pharmacol. 2019 ;10:883

Inhibition of β-Glucocerebrosidase Activity Preserves Motor Unit Integrity in a Mouse Model of Amyotrophic Lateral Sclerosis.

Henriques A, Huebecker M, Blasco H, Keime C, Andres CR, Corcia P, Priestman DA, Platt FM, Spedding M, Loeffler JP

Sci Rep. 2017 Jul;7(1):5235

Autophagy in neuroinflammatory diseases.

Muller S, Brun S, René F, de Sèze J, Loeffler JP, Jeltsch-David H

Autoimmun Rev. 2017 May;:

Sphingolipid Metabolism Is Dysregulated at Transcriptomic and Metabolic Levels in the Spinal Cord of an Animal Model of Amyotrophic Lateral Sclerosis.

Henriques A, Croixmarie V, Bouscary A, Mosbach A, Keime C, Boursier-Neyret C, Walter B, Spedding M, Loeffler JP

Front Mol Neurosci. 2017 ;10:433

A transgenic mouse expressing CHMP2Bintron5 mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia.

Vernay A, Therreau L, Blot B, Risson V, Dirrig-Grosch S, Waegaert R, Lequeu T, Sellal F, Schaeffer L, Sadoul R, Loeffler JP, René F

Hum. Mol. Genet.. 2016 Aug;25(15):3341-3360

APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation.

Stanga S, Zanou N, Audouard E, Tasiaux B, Contino S, Vandermeulen G, René F, Loeffler JP, Clotman F, Gailly P, Dewachter I, Octave JN, Kienlen-Campard P

FASEB J.. 2016 May;30(5):1696-711

Late-Life Environmental Enrichment Induces Acetylation Events and Nuclear Factor κB-Dependent Regulations in the Hippocampus of Aged Rats Showing Improved Plasticity and Learning.

Neidl R, Schneider A, Bousiges O, Majchrzak M, Barbelivien A, de Vasconcelos AP, Dorgans K, Doussau F, Loeffler JP, Cassel JC, Boutillier AL

J. Neurosci.. 2016 Apr;36(15):4351-61

The Role of Skeletal Muscle in Amyotrophic Lateral Sclerosis.

Loeffler JP, Picchiarelli G, Dupuis L, Gonzalez De Aguilar JL

Brain Pathol.. 2016 Mar;26(2):227-36

Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase.

Henriques A, Croixmarie V, Priestman DA, Rosenbohm A, Dirrig-Grosch S, D'Ambra E, Huebecker M, Hussain G, Boursier-Neyret C, Echaniz-Laguna A, Ludolph AC, Platt FM, Walther B, Spedding M, Loeffler JP, Gonzalez De Aguilar JL

Hum Mol Genet. 2015 Oct 19. pii: ddv439.

A common functional allele of the Nogo receptor gene, reticulon 4 receptor (RTN4R), is associated with sporadic amyotrophic lateral sclerosis in a French population.

Amy M, Staehlin O, Rene F, Blasco H, Marouillat S, Daoud H, Vourc'h P, Gordon PH, Camu W, Corcia P, Loeffler JP, Palkovits M, Sommer WH, Andres CR

Amyotroph Lateral Scler Frontotemporal Degener. 2015 Jun 17:1-7.

Endplate denervation correlates with Nogo-A muscle expression in amyotrophic lateral sclerosis patients.

Bruneteau G, Bauche S, Gonzalez de Aguilar JL, Brochier G, Mandjee N, Tanguy ML, Hussain G, Behin A, Khiami F, Sariali E, Hell-Remy C, Salachas F, Pradat PF, Lacomblez L, Nicole S, Fontaine B, Fardeau M, Loeffler JP, Meininger V, Fournier E, Koenig J, Hantai D

Ann Clin Transl Neurol. 2015 Apr;2(4):362-72

A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis.

Palamiuc L, Schlagowski A, Ngo ST, Vernay A, Dirrig-Grosch S, Henriques A, Boutillier AL, Zoll J, Echaniz-Laguna A, Loeffler JP, Rene F

EMBO Mol Med. 2015 Mar 27. pii: e201404433

Blood Cell Palmitoleate-Palmitate Ratio Is an Independent Prognostic Factor for Amyotrophic Lateral Sclerosis.

Henriques A, Blasco H, Fleury MC, Corcia P, Echaniz-Laguna A, Robelin L, Rudolf G, Lequeu T, Bergaentzle M, Gachet C, Pradat PF, Marchioni E, Andres CR, Tranchant C, Gonzalez De Aguilar JL, Loeffler JP

PLoS One. 2015 Jul 6;10(7):e0131512

A plural role for lipids in motor neuron diseases: energy, signaling and structure.

Schmitt F, Hussain G, Dupuis L, Loeffler JP, Henriques A

Front Cell Neurosci. 2014 Feb 20;8:25

Full-length PGC-1alpha salvages the phenotype of a mouse model of human neuropathy through mitochondrial proliferation.

Rona-Voros K, Eschbach J, Vernay A, Wiesner D, Schwalenstocker B, Geniquet P, Mousson De Camaret B, Echaniz-Laguna A, Loeffler JP, Ludolph AC, Weydt P, Dupuis L

Hum Mol Genet. 2013 Dec 20;22(25):5096-106

Dynein mutations associated with hereditary motor neuropathies impair mitochondrial morphology and function with age.

Eschbach J, Sinniger J, Bouitbir J, Fergani A, Schlagowski AI, Zoll J, Geny B, Rene F, Larmet Y, Marion V, Baloh RH, Harms MB, Shy ME, Messadeq N, Weydt P, Loeffler JP, Ludolph AC, Dupuis L

Neurobiol Dis. 2013 Oct;58:220-30

Investigating the contribution of VAPB/ALS8 loss of function in amyotrophic lateral sclerosis.

Kabashi E, El Oussini H, Bercier V, Gros-Louis F, Valdmanis PN, McDearmid J, Mejier IA, Dion PA, Dupre N, Hollinger D, Sinniger J, Dirrig-Grosch S, Camu W, Meininger V, Loeffler JP, Rene F, Drapeau P, Rouleau GA, Dupuis L

Hum Mol Genet. 2013 Jun 15;22(12):2350-60

Degeneration of serotonergic neurons in amyotrophic lateral sclerosis: a link to spasticity.

Dentel C, Palamiuc L, Henriques A, Lannes B, Spreux-Varoquaux O, Gutknecht L, Rene F, Echaniz-Laguna A, Gonzalez de Aguilar JL, Lesch KP, Meininger V, Loeffler JP, Dupuis L

Brain. 2013 Feb;136(Pt 2):483-93

Detection of histone acetylation levels in the dorsal hippocampus reveals early tagging on specific residues of H2B and H4 histones in response to learning.

Bousiges O, Neidl R, Majchrzak M, Muller MA, Barbelivien A, Pereira de Vasconcelos A, Schneider A, Loeffler JP, Cassel JC, Boutillier AL

PLoS One. 2013;8(3):e57816

Fatting the brain: a brief of recent research.

Hussain G, Schmitt F, Loeffler JP, de Aguilar JL

Front Cell Neurosci. 2013 Sep 9;7:144

Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity.

Vidimar V, Meng X, Klajner M, Licona C, Fetzer L, Harlepp S, Hebraud P, Sidhoum M, Sirlin C, Loeffler JP, Mellitzer G, Sava G, Pfeffer M, Gaiddon C

Biochem Pharmacol. 2012 Dec 1;84(11):1428-36

Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain.

Kaindl AM, Degos V, Peineau S, Gouadon E, Chhor V, Loron G, Le Charpentier T, Josserand J, Ali C, Vivien D, Collingridge GL, Lombet A, Issa L, Rene F, Loeffler JP, Kavelaars A, Verney C, Mantz J, Gressens P

Ann Neurol. 2012 Oct;72(4):536-49

BBS-induced ciliary defect enhances adipogenesis, causing paradoxical higher-insulin sensitivity, glucose usage, and decreased inflammatory response.

Marion V, Mockel A, De Melo C, Obringer C, Claussmann A, Simon A, Messaddeq N, Durand M, Dupuis L, Loeffler JP, King P, Mutter-Schmidt C, Petrovsky N, Stoetzel C, Dollfus H

Cell Metab. 2012 Sep 5;16(3):363-77

Muscle gene expression is a marker of amyotrophic lateral sclerosis severity.

Pradat PF, Dubourg O, de Tapia M, di Scala F, Dupuis L, Lenglet T, Bruneteau G, Salachas F, Lacomblez L, Corvol JC, Demougin P, Primig M, Meininger V, Loeffler JP, Gonzalez de Aguilar JL

Neurodegener Dis. 2012;9(1):38-52

The Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctions.

Audouard E, Schakman O, Rene F, Huettl RE, Huber AB, Loeffler JP, Gailly P, Clotman F

PLoS One. 2012;7(12):e50509

Complex regulation of p73 isoforms after alteration of amyloid precursor polypeptide (APP) function and DNA damage in neurons.

Benosman S, Meng X, Von Grabowiecki Y, Palamiuc L, Hritcu L, Gross I, Mellitzer G, Taya Y, Loeffler JP, Gaiddon C

J Biol Chem. 2011 Dec 16;286(50):43013-25

A mutation in the dynein heavy chain gene compensates for energy deficit of mutant SOD1 mice and increases potentially neuroprotective IGF-1.

Fergani A, Eschbach J, Oudart H, Larmet Y, Schwalenstocker B, Ludolph AC, Loeffler JP, Dupuis L

Mol Neurodegener. 2011 Apr 26;6(1):26.

Energy metabolism in amyotrophic lateral sclerosis.

Dupuis L, Pradat PF, Ludolph AC, Loeffler JP

Lancet Neurol. 2011 Jan;10(1):75-82

Mutations in cytoplasmic dynein lead to a Huntington's disease-like defect in energy metabolism of brown and white adipose tissues.

Eschbach J, Fergani A, Oudart H, Robin JP, Rene F, Gonzalez de Aguilar JL, Larmet Y, Zoll J, Hafezparast M, Schwalenstocker B, Loeffler JP, Ludolph AC, Dupuis L

Biochim Biophys Acta. 2011 Jan;1812(1):59-69

A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons.

Braunstein KE, Eschbach J, Rona-Voros K, Soylu R, Mikrouli E, Larmet Y, Rene F, De Aguilar JL, Loeffler JP, Muller HP, Bucher S, Kaulisch T, Niessen HG, Tillmanns J, Fischer K, Schwalenstocker B, Kassubek J, Pichler B, Stiller D, Petersen A, Ludolph AC, Dupuis L

Hum Mol Genet. 2010 Nov 15;19(22):4385-98

P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis.

Milane A, Fernandez C, Dupuis L, Buyse M, Loeffler JP, Farinotti R, Meininger V, Bensimon G

Neurosci Lett. 2010 Mar 26;472(3):166-70

Guidelines for preclinical animal research in ALS/MND: A consensus meeting

Ludolph AC, Bendotti C, Blaugrund E, Chio A, Greensmith L, Loeffler JP, Mead R, Niessen HG, Petri S, Pradat PF, Robberecht W, Ruegg M, Schwalenstocker B, Stiller D, van den Berg L, Vieira F, von Horsten S

Amyotroph Lateral Scler. 2010;11(1-2):38-45.

Impaired glucose tolerance in patients with amyotrophic lateral sclerosis.

Pradat PF, Bruneteau G, Gordon PH, Dupuis L, Bonnefont-Rousselot D, Simon D, Salachas F, Corcia P, Frochot V, Lacorte JM, Jardel C, Coussieu C, Le Forestier N, Lacomblez L, Loeffler JP, Meininger V

Amyotroph Lateral Scler. 2010;11(1-2):166-71.

Platelet serotonin level predicts survival in amyotrophic lateral sclerosis.

Dupuis L, Spreux-Varoquaux O, Bensimon G, Jullien P, Lacomblez L, Salachas F, Bruneteau G, Pradat PF, Loeffler JP, Meininger V

PLoS One. 2010 Oct 13;5(10):e13346.

Electrophysiological studies in a mouse model of Schwartz-Jampel syndrome demonstrate muscle fiber hyperactivity of peripheral nerve origin.

Echaniz-Laguna A, Rene F, Marcel C, Bangratz M, Fontaine B, Loeffler JP, Nicole S

Muscle Nerve. 2009 Jul;40(1):55-61.

Mice with a mutation in the dynein heavy chain 1 gene display sensory neuropathy but lack motor neuron disease.

Dupuis L, Fergani A, Braunstein KE, Eschbach J, Holl N, Rene F, Gonzalez De Aguilar JL, Zoerner B, Schwalenstocker B, Ludolph AC, Loeffler JP

Exp Neurol. 2009 Jan;215(1):146-52

Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons.

Dupuis L, Gonzalez de Aguilar JL, Echaniz-Laguna A, Eschbach J, Rene F, Oudart H, Halter B, Huze C, Schaeffer L, Bouillaud F, Loeffler JP

PLoS One. 2009;4(4):e5390

[Amyotrophic lateral sclerosis: role of energy deficiency in neuromuscular junction dismantlement]

Dupuis L, Loeffler JP

Med Sci (Paris). 2008 Dec;24(12):1077-82.

Dyslipidemia is a protective factor in amyotrophic lateral sclerosis.

Goldstein MR, Mascitelli L, Pezzetta F

Neurology. 2008 Sep 16;71(12):956; author reply 956-7.

Histone deacetylase inhibitors: Therapeutic agents and research tools for deciphering motor neuron diseases

Echaniz-Laguna A, Bousiges O, Loeffler JP, Boutillier AL

Curr Med Chem. 2008;15(13):1263-73.

Dyslipidemia is a protective factor in amyotrophic lateral sclerosis

Dupuis L, Corcia P, Fergani A, De Aguilar JLG, Bonnefont-Rousselot D, Bittar R, Seilhean D, Hauw JJ, Lacomblez L, Loeffler JP, Meininger V

Neurology. 2008 Mar 25;70(13):1004-9

Evaluation of the ability of an organic derivative of ruthenium(II) to reinforce the cytotoxicity of fast neutron against malignant cells in culture

Leyva L, Malek F, Benzina S, Denis JM, Gueulette J, Dufour P, Gaiddon C, Loeffler JP, Sirlin C, Pfeffer M, Bischoff P

Lett Drug Des Discov. 2008 Jan;5(1):1-6

Gene profiling of skeletal muscle in an amyotrophic lateral sclerosis mouse model.

Gonzalez de Aguilar JL, Niederhauser-Wiederkehr C, Halter B, De Tapia M, Di Scala F, Demougin P, Dupuis L, Primig M, Meininger V, Loeffler JP

Physiol Genomics. 2008 Jan 17;32(2):207-18

Nogo receptor antagonizes p75NTR-dependent motor neuron death

Dupuis L, Pehar M, Cassina P, Rene F, Castellanos R, Rouaux C, Gandelman M, Dimou L, Schwab ME, Loeffler JP, Barbeito L, de Aguilar JLG

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):740-5

Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis.

Benosman S, Gross I, Clarke N, Jochemsen AG, Okamoto K, Loeffler JP, Gaiddon C

Cell Death Differ. 2007 Dec;14(12):2047-57

PdCl2, a useful catalyst for protection of alcohols as diphenylmethyl (DPM) ethers

Bikard Y, Weibel JM, Sirlin C, Dupuis L, Loeffler JP, Pale P

Tetrahedron Lett. 2007 Dec 10;48(50):8895-9

Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival.

Gross I, Armant O, Benosman S, de Aguilar JL, Freund JN, Kedinger M, Licht JD, Gaiddon C, Loeffler JP

Cell Death Differ. 2007 Oct;14(10):1802-12

HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation.

Panteleeva I, Boutillier S, See V, Spiller DG, Rouaux C, Almouzni G, Bailly D, Maison C, Lai HC, Loeffler JP, Boutillier AL

EMBO J. 2007 Aug 8;26(15):3616-28

Increased peripheral lipid clearance in an animal model of amyotrophic lateral sclerosis.

Fergani A, Oudart H, Gonzalez De Aguilar JL, Fricker B, Rene F, Hocquette JF, Meininger V, Dupuis L, Loeffler JP

J Lipid Res. 2007 Jul;48(7):1571-80

Muscle Nogo-A expression is a prognostic marker in lower motor neuron syndromes.

Pradat PF, Bruneteau G, Gonzalez de Aguilar JL, Dupuis L, Jokic N, Salachas F, Le Forestier N, Echaniz-Laguna A, Dubourg O, Hauw JJ, Tranchant C, Loeffler JP, Meininger V

Ann Neurol. 2007 Jul;62(1):15-20.

Synthesis of cycloruthenated compounds as potential anticancer agents

Leyva L, Sirlin C, Rubio L, Franco C, Le Lagadec R, Spencer J, Bischoff P, Gaiddon C, Loeffler JP, Pfeffer M

Eur J Inorg Chem. 2007 Jul;19:3055-66

Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model.

Rouaux C, Panteleeva I, Rene F, Gonzalez de Aguilar JL, Echaniz-Laguna A, Dupuis L, Menger Y, Boutillier AL, Loeffler JP

J Neurosci. 2007 May 23;27(21):5535-45.

Sp3 and sp4 transcription factor levels are increased in brains of patients with Alzheimer's disease.

Boutillier S, Lannes B, Buee L, Delacourte A, Rouaux C, Mohr M, Bellocq JP, Sellal F, Larmet Y, Boutillier AL, Loeffler JP

Neurodegener Dis. 2007;4(6):413-23

The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model.

Jokic N, Gonzalez de Aguilar JL, Dimou L, Lin S, Fergani A, Ruegg MA, Schwab ME, Dupuis L, Loeffler JP

EMBO Rep. 2006 Nov;7(11):1162-7

Elevated levels of amyloid precursor protein in muscle of patients with amyotrophic lateral sclerosis and a mouse model of the disease.

Koistinen H, Prinjha R, Soden P, Harper A, Banner SJ, Pradat PF, Loeffler JP, Dingwall C

Muscle Nerve. 2006 Oct;34(4):444-50.

Mitochondrial dysfunction in amyotrophic lateral sclerosis also affects skeletal muscle.

Dupuis L, Gonzalez de Aguilar JL, Echaniz-Laguna A, Loeffler JP

Muscle Nerve. 2006 Aug;34(2):253-4.

Muscular mitochondrial function in amyotrophic lateral sclerosis is progressively altered as the disease develops: a temporal study in man.

Echaniz-Laguna A, Zoll J, Ponsot E, N'guessan B, Tranchant C, Loeffler JP, Lampert E

Exp Neurol. 2006 Mar;198(1):25-30

Ruthenium (II)-derived organometallic compounds induce cytostatic and cytotoxic effects on mammalian cancer cell lines through p53-dependent and p53-independent mechanisms.

Gaiddon C, Jeannequin P, Bischoff P, Pfeffer M, Sirlin C, Loeffler JP

J Pharmacol Exp Ther. 2005 Dec;315(3):1403-11

Antibody-bound beta-amyloid precursor protein stimulates the production of tumor necrosis factor-alpha and monocyte chemoattractant protein-1 by cortical neurons.

Mbebi C, Gonzalez de Aguilar JL, See V, Dupuis L, Frossard N, Mercken L, Pradier L, Larmet Y, Loeffler JP

Neurobiol Dis. 2005 Jun-Jul;19(1-2):129-41.

Dr LOEFFLER Jean-Philippe

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