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H3K9ac of TGFβRI in human umbilical cord: a potential biomarker for evaluating cartilage differentiation and susceptibility to osteoarthritis via a two-step strategy.

Qi Y, Li B, Wen Y, Yang X, Chen B, He Z, Zhao Z, Magdalou J, Wang H, Chen L

Stem Cell Res Ther. 2021 Mar 4;12(1):163

Lentivirus-delivered ACE siRNA rescues the impaired peak bone mass accumulation caused by prenatal dexamethasone exposure in male offspring rats.

Xiao H, Wen Y, Wu Z, Chen H, Magdalou J, Wang H, Chen L

Bone. 2020 Aug 10;:115578

The low-expression programming of 11β-HSD2 mediates osteoporosis susceptibility induced by prenatal caffeine exposure in male offspring rats.

Xiao H, Wu Z, Li B, Shangguan Y, Stoltz JF, Magdalou J, Chen L, Wang H

Br. J. Pharmacol.. 2020 Aug 5;:

Articular damages in multi-generational female offspring due to prenatal caffeine exposure correlates with H3K9 deacetylation of TGFβ signaling pathway.

Zhao Z, Qin J, Pei L, He Z, Luo H, Magdalou J, Chen L, Wang H

Toxicology. 2020 Jul 11;:152533

GR/HDAC2/TGFβR1 pathway contributes to prenatal caffeine induced-osteoarthritis susceptibility in male adult offspring rats.

Li J, Xiao H, Luo H, Tan Y, Ni Q, He C, Magdalou J, Chen L, Wang H

Food Chem. Toxicol.. 2020 Mar 18;:111279

Subchondral bone dysplasia partly participates in prenatal dexamethasone induced-osteoarthritis susceptibility in female offspring rats.

Xiao H, Xie X, Wen Y, Tan Y, Shangguan Y, Li B, Magdalou J, Wang H, Chen L

Bone. 2020 Jan 18;:115245

Subchondral bone dysplasia mediates susceptibility to osteoarthritis in female adult offspring rats induced by prenatal caffeine exposure.

Xie X, Tan Y, Xiao H, Wen Y, Magdalou J, Wang H, Chen L

Toxicol. Lett.. 2019 Dec 21;:

Nicotine exposure during pregnancy programs osteopenia in male offspring rats α4β2-nAChR-p300-ACE pathway.

Xiao H, Wen Y, Pan Z, Shangguan Y, Magdalou J, Wang H, Chen L

FASEB J.. 2019 Sep 7;:fj201901145RR

Prenatal caffeine exposure induces liver developmental dysfunction in offspring rats.

He B, Wen Y, Hu S, Wang G, Hu W, Magdalou J, Chen L, Wang H

J. Endocrinol.. 2019 Jul 1;:

Glucocorticoid programming mechanism for hypercholesterolemia in prenatal ethanol-exposed adult offspring rats.

Hu S, Qin J, Zhou J, Magdalou J, Chen L, Xu D, Wang H

Toxicol. Appl. Pharmacol.. 2019 May 7;:

Synergistic effects of prenatal nicotine exposure and post-weaning high-fat diet on hypercholesterolaemia in rat offspring of different sexes.

Zhu C, Guo Y, Luo H, Wu Y, Magdalou J, Chen L, Wang H

Basic Clin. Pharmacol. Toxicol.. 2018 Dec 14;:

Glucocorticoid-activation system mediated glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming alteration of adrenal dysfunction induced by prenatal caffeine exposure.

He Z, Zhang J, Huang H, Yuan C, Zhu C, Magdalou J, Wang H

Toxicol. Lett.. 2018 Dec 6;:

Activation of local bone RAS by maternal excessive glucocorticoid participated in the fetal programing of adult osteopenia induced by prenatal caffeine exposure.

Wen Y, Shangguan Y, Pan Z, Hu H, Magdalou J, Chen L, Wang H

Toxicol. Appl. Pharmacol.. 2018 Nov 10;:

Prenatal caffeine exprosure increases adult female offspring rat's susceptibility to osteoarthritis via low-functional programming of cartilage IGF-1 with histone acetylation.

Tan Y, Lu K, Li J, Ni Q, Zhao Z, Magdalou J, Chen L, Wang H

Toxicol. Lett.. 2018 Oct 1;295:229-236

Intrauterine programming of Glucocorticoid-Insulin-Like Growth Factor 1 axis-mediated developmental origin of osteoporosis susceptibility in female offspring rats of prenatal caffeine exposure.

Shangguan Y, Wen Y, Tan Y, Qin J, Jiang H, Magdalou J, Chen L, Wang H

Am. J. Pathol.. 2018 Sep 28;:

Two intrauterine programming mechanisms of adult hypercholesterolemia induced by prenatal nicotine exposure in male offspring rats.

Zhou J, Zhu C, Luo H, Shen L, Gong J, Wu Y, Magdalou J, Chen L, Guo Y, Wang H

FASEB J.. 2018 Aug 16;:fj201800172R

Influencing factors, underlying mechanism and interactions affecting hypercholesterolemia in adult offspring with caffeine exposure during pregnancy.

Guo Y, Luo H, Wu Y, Magdalou J, Chen L, Wang H

Reprod. Toxicol.. 2018 08;79:47-56

Prenatal nicotine exposure intergenerationally programs imperfect articular cartilage via histone deacetylation through maternal lineage.

Xie Z, Zhao Z, Yang X, Pei L, Luo H, Ni Q, Li B, Qi Y, Tie K, Magdalou J, Chen L, Wang H

Toxicol. Appl. Pharmacol.. 2018 Aug 1;352:107-118

Role of TGFβ Signaling in Maternal Ethanol-Induced Fetal Articular Cartilage Dysplasia and Adult Onset of Osteoarthritis in Male Rats.

Ni Q, Lu K, Li J, Tan Y, Qin J, Magdalou J, Chen L, Wang H

Toxicol. Sci.. 2018 Jul 1;164(1):179-190

Intrauterine programming mechanism for hypercholesterolemia in prenatal caffeine-exposed female adult rat offspring.

Xu D, Luo HW, Hu W, Hu SW, Yuan C, Wang GH, Zhang L, Yu H, Magdalou J, Chen LB, Wang H

FASEB J.. 2018 May 2;:fj201701557R

Umbilical cord-derived mesenchymal stromal cells: predictive obstetric factors for cell proliferation and chondrogenic differentiation.

Avercenc-Léger L, Guerci P, Virion JM, Cauchois G, Hupont S, Rahouadj R, Magdalou J, Stoltz JF, Bensoussan D, Huselstein C, Reppel L

Stem Cell Res Ther. 2017 Jul;8(1):161

Hypoxia for MSC expansion and differentiation: the best way for enhancing TGFß-induced chondrogenesis and preventing calcifications in alginate beads.

Henrionnet C, Liang G, Roeder E, Dossot M, Wang H, Magdalou J, Gillet P, Pinzano A

Tissue Eng Part A. 2017 Apr;:

Effect of nicotine on the proliferation and chondrogenic differentiation of the human Wharton's jelly mesenchymal stem cells.

Yang X, Qi Y, Avercenc-Leger L, Vincourt JB, Hupont S, Huselstein C, Wang H, Chen L, Magdalou J

Biomed Mater Eng. 2017 ;28(s1):S217-S228

Expression of the semicarbazide-sensitive amine oxidase in articular cartilage: its role in terminal differentiation of chondrocytes in rat and human.

Filip A, Pinzano A, Bianchi A, Fève B, Jalkanen S, Gillet P, Mainard D, Lacolley P, Magdalou J, Mercier N

Osteoarthr. Cartil.. 2016 Jul;24(7):1223-34

Prenatal caffeine exposure-induced adrenal developmental abnormality in male offspring rats and its possible intrauterine programming mechanisms.

He Z, Zhu C, Huang H, Liu L, Wang L, Chen L, Magdalou J, Wang H

Toxicol Res (Camb). 2016 Mar 1;5(2):388-398

Stem cells and vascular regenerative medicine: A mini review.

Stoltz JF, Bensoussan D, De Isla N, Zhang L, Han Z, Magdalou J, Huselstein C, Ye JS, Leballe B, Decot V, Reppel L

Clin. Hemorheol. Microcirc.. 2016 ;64(4):613-633

Prenatal ethanol exposure induces the osteoarthritis-like phenotype in female adult offspring rats with a post-weaning high-fat diet and its intrauterine programming mechanisms of cholesterol metabolism.

Ni Q, Wang L, Wu Y, Shen L, Qin J, Liu Y, Magdalou J, Chen L, Wang H

Toxicol. Lett.. 2015 Oct 14;238(2):117-25

Prenatal ethanol exposure increases osteoarthritis susceptibility in female rat offspring by programming a low-functioning IGF-1 signaling pathway.

Ni Q, Tan Y, Zhang X, Luo H, Deng Y, Magdalou J, Chen L, Wang H

Sci Rep. 2015 Oct 5;5:14711

In malignant cartilagenous tumors, immunohistochemical expression of procollagen PC1CP peptide is higher and that of PC2CP lower than in benign cartilaginous lesions.

Delaunay-Lemarie C, Vincourt JB, Marie B, Battaglia-Hsu SF, Etienne S, Sirveaux F, Nguyen Thi PL, Magdalou J, Vignaud JM, Gauchotte G

Virchows Arch. 2015 Sep;467(3):329-37

Gender-specific increase in susceptibility to metabolic syndrome of offspring rats after prenatal caffeine exposure with post-weaning high-fat diet.

Li J, Luo H, Wu Y, He Z, Zhang L, Guo Y, Ma L, Magdalou J, Chen L, Wang H

Toxicol. Appl. Pharmacol.. 2015 May 1;284(3):345-53

A simple two dimensional culture method to study the hypertrophic differentiation of rat articular chondrocytes.

Filip A, Bianchi A, Mainard D, Lacolley P, Magdalou J, Mercier N

Biomed Mater Eng. 2015;25(1 Suppl):87-102

Angelica sinensis and osteoarthritis: a natural therapeutic link?

Magdalou J, Chen LB, Wang H, Qin J, Wen Y, Li XJ, Shang L, Li J

Biomed Mater Eng. 2015 ;25(1 Suppl):179-86

Label-free relative quantification applied to LC-MALDI acquisition for rapid analysis of chondrocyte secretion modulation.

Riffault M, Moulin D, Grossin L, Mainard D, Magdalou J, Vincourt JB

J Proteomics. 2015 Jan 30;114:263-73

Stem Cells and Regenerative Medicine: Myth or Reality of the 21th Century.

Stoltz JF, de Isla N, Li YP, Bensoussan D, Zhang L, Huselstein C, Chen Y, Decot V, Magdalou J, Li N, Reppel L, He Y

Stem Cells Int. 2015;2015:734731

UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis.

Wen Y, Li J, Wang L, Tie K, Magdalou J, Chen L, Wang H

Arthritis Res. Ther.. 2014 Dec 3;16(6):484

The critical role of UDP-galactose-4-epimerase in osteoarthritis: modulating proteoglycans synthesis of the articular chondrocytes.

Wen Y, Qin J, Deng Y, Wang H, Magdalou J, Chen L

Biochem. Biophys. Res. Commun.. 2014 Oct 3;452(4):906-11

CYP 2C19 and UDP-glucuronosyltransferases not only for drugs but also for endobiotics.

Siest G, Fournel-Gigleux S, Magdalou J

Drug Metabol Drug Interact. 2014;29(4):207-9

The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication.

Ouzzine M, Gulberti S, Ramalanjaona N, Magdalou J, Fournel-Gigleux S

Front Cell Neurosci. 2014 Oct 28;8:349

Osteogenic differentiation of human bone marrow mesenchymal stem cells in hydrogel containing nacre powder.

Flausse A, Henrionnet C, Dossot M, Dumas D, Hupont S, Pinzano A, Mainard D, Galois L, Magdalou J, Lopez E, Gillet P, Rousseau M

J Biomed Mater Res A. 2013 Nov;101(11):3211-8

Chondrocalcin is internalized by chondrocytes and triggers cartilage destruction via an interleukin-1beta-dependent pathway.

Bantsimba-Malanda C, Cottet J, Netter P, Dumas D, Mainard D, Magdalou J, Vincourt JB

Matrix Biol. 2013 Oct-Nov;32(7-8):443-51

The cucurbitacins E, D and I: investigation of their cytotoxicity toward human chondrosarcoma SW 1353 cell line and their biotransformation in man liver.

Abbas S, Vincourt JB, Habib L, Netter P, Greige-Gerges H, Magdalou J

Toxicol Lett. 2013 Feb 4;216(2-3):189-99

Regulation of xylosyltransferase I gene expression by interleukin 1beta in human primary chondrocyte cells: mechanism and impact on proteoglycan synthesis.

Khair M, Bourhim M, Barre L, Li D, Netter P, Magdalou J, Fournel-Gigleux S, Ouzzine M

J Biol Chem. 2013 Jan 18;288(3):1774-84

Measurement of matrilin-3 levels in human serum and synovial fluid using a competitive enzyme-linked immunosorbent assay.

Vincourt JB, Gillet P, Rat AC, Guillemin F, Netter P, Mainard D, Magdalou J

Osteoarthritis Cartilage. 2012 Jul;20(7):783-6

Matrilin-3 switches from anti- to pro-anabolic upon integration to the extracellular matrix.

Vincourt JB, Etienne S, Grossin L, Cottet J, Bantsimba-Malanda C, Netter P, Mainard D, Libante V, Gillet P, Magdalou J

Matrix Biol. 2012 Jun;31(5):290-8

Chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) involved in chondroitin sulfate initiation: Impact of sulfation on activity and specificity.

Gulberti S, Jacquinet JC, Chabel M, Ramalanjaona N, Magdalou J, Netter P, Coughtrie MW, Ouzzine M, Fournel-Gigleux S

Glycobiology. 2012 Apr;22(4):561-71

Introduction to regenerative medicine and tissue engineering.

Stoltz JF, Decot V, Huseltein C, He X, Zhang L, Magdalou J, Li YP, Menu P, Li N, Wang YY, de Isla N, Bensoussan D

Biomed Mater Eng. 2012;22(1-3):3-16

SHG as a new modality for large field of view imaging to monitor tissue collagen network.

Dumas D, Hupont S, Huselstein C, de Isla N, Rousseau M, Werkmeister E, Magdalou J, Menu P, Stoltz JF

Biomed Mater Eng. 2012 ;22(1-3):159-62

Xylosyltransferase-I regulates glycosaminoglycan synthesis during the pathogenic process of human osteoarthritis.

Venkatesan N, Barre L, Bourhim M, Magdalou J, Mainard D, Netter P, Fournel-Gigleux S, Ouzzine M

PLoS One. 2012;7(3):e34020

Biochemical and thermodynamic characterization of mutated beta1,4-galactosyltransferase 7 involved in the progeroid form of the Ehlers-Danlos syndrome.

Rahuel-Clermont S, Daligault F, Piet MH, Gulberti S, Netter P, Branlant G, Magdalou J, Lattard V

Biochem J. 2010 Dec 1;432(2):303-11.

C-propeptides of procollagens I{alpha}1 and II that differentially accumulate in enchondromas versus chondrosarcomas regulate tumor cell survival and migration.

Vincourt JB, Etienne S, Cottet J, Delaunay C, Malanda B, Lionneton F, Sirveaux F, Netter P, Plenat F, Mainard D, Vignaud JM, Magdalou J

Cancer Res. 2010 Jun 1;70(11):4739-48

Insights on membrane topology and structure/function of UDP-glucuronosyltransferases.

Magdalou J, Fournel-Gigleux S, Ouzzine M

Drug Metab Rev. 2010;42(1):154-61.

Introduction to tissue engineering and application for cartilage engineering.

de Isla N, Huseltein C, Jessel N, Pinzano A, Decot V, Magdalou J, Bensoussan D, Stoltz JF

Biomed Mater Eng. 2010 Jan 1;20(3):127-33.

Original approach for cartilage tissue engineering with mesenchymal stem cells.

Tritz-Schiavi J, Charif N, Henrionnet C, de Isla N, Bensoussan D, Magdalou J, Benkirane-Jessel N, Stoltz JF, Huselstein C

Biomed Mater Eng. 2010 Jan 1;20(3):167-74.

The use of hepatocytes to investigate UDP-glucuronosyltransferases and sulfotransferases.

Fournel-Gigleux S, Coughtrie MW, Ouzzine M, Magdalou J

Methods Mol Biol. 2010;640:309-26.

Modulation of xylosyltransferase I expression provides a mechanism regulating glycosaminoglycan chain synthesis during cartilage destruction and repair.

Venkatesan N, Barre L, Magdalou J, Mainard D, Netter P, Fournel-Gigleux S, Ouzzine M

FASEB J. 2009 Mar;23(3):813-22

Thermodynamic insights into the structural basis governing the donor substrate recognition by human beta1,4-galactosyltransferase 7.

Daligault F, Rahuel-Clermont S, Gulberti S, Cung MT, Branlant G, Netter P, Magdalou J, Lattard V

Biochem J. 2009 Mar 15;418(3):605-14.

Bio-Medical Materials and Engineering. Foreword.

Stoltz JF, Magdalou J, Netter P, de Isla N

Biomed Mater Eng. 2009 ;19(4-5):269

Increased expression of matrilin-3 not only in osteoarthritic articular cartilage but also in cartilage-forming tumors, and down-regulation of SOX9 via epidermal growth factor domain 1-dependent signaling.

Vincourt JB, Vignaud JM, Lionneton F, Sirveaux F, Kawaki H, Marchal S, Lomazzi S, Plenat F, Guillemin F, Netter P, Takigawa M, Mainard D, Magdalou J

Arthritis Rheum. 2008 Sep;58(9):2798-808.

[Agrecan and articular cartilage: assessment of glycosyltransferases for the restoration of cartilage matrix in osteoarthritis]

Magdalou J, Netter P, Fournel-Gigleux S, Ouzzine M

J Soc Biol. 2008;202(4):281-8

Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33.

Barre L, Fournel-Gigleux S, Finel M, Netter P, Magdalou J, Ouzzine M

FEBS J. 2007 Mar;274(5):1256-64

Establishment of a reliable method for direct proteome characterization of human articular cartilage.

Vincourt JB, Lionneton F, Kratassiouk G, Guillemin F, Netter P, Mainard D, Magdalou J

Mol. Cell Proteomics. 2006 Oct;5(10):1984-95

[Chondrocyte glycosyltransferases: new pharmacological targets for degenerative diseases of articular cartilage?].

Magdalou J, Ouzzine M, Netter P, Fournel-Gigleux S

Bull Acad Natl Med. 2006 Oct;190(7):1385-97; discussion 1397-8, 1475-7.

Phylogenetic and mutational analyses reveal key residues for UDP-glucuronic acid binding and activity of beta1,3-glucuronosyltransferase I (GlcAT-I).

Fondeur-Gelinotte M, Lattard V, Oriol R, Mollicone R, Jacquinet JC, Mulliert G, Gulberti S, Netter P, Magdalou J, Ouzzine M, Fournel-Gigleux S

Protein Sci. 2006 Jul;15(7):1667-78.

Purification and characterization of a soluble form of the recombinant human galactose-beta1,3-glucuronosyltransferase I expressed in the yeast Pichia pastoris.

Lattard V, Fondeur-Gelinotte M, Gulberti S, Jacquinet JC, Boudrant J, Netter P, Magdalou J, Ouzzine M, Fournel-Gigleux S

Protein Expr Purif. 2006 May;47(1):137-43

Role of the carboxyl terminal stop transfer sequence of UGT1A6 membrane protein in ER targeting and translocation of upstream lumenal domain.

Ouzzine M, Barre L, Netter P, Magdalou J, Fournel-Gigleux S

FEBS Lett. 2006 Apr 3;580(8):1953-8

Modifications of the glycosaminoglycan-linkage region of proteoglycans: phosphorylation and sulfation determine the activity of the human beta1,4-galactosyltransferase 7 and beta1,3-glucuronosyltransferase I.

Gulberti S, Lattard V, Fondeur M, Jacquinet JC, Mulliert G, Netter P, Magdalou J, Ouzzine M, Fournel-Gigleux S

ScientificWorldJournal. 2005 Jul 12;5:510-4.

The donor substrate specificity of the human beta 1,3-glucuronosyltransferase I toward UDP-glucuronic acid is determined by two crucial histidine and arginine residues.

Ouzzine M, Gulberti S, Levoin N, Netter P, Magdalou J, Fournel-Gigleux S

J Biol Chem. 2002 Jul 12;277(28):25439-45

Evidence for the presence of peroxisome proliferator-activated receptor (PPAR) alpha and gamma and retinoid Z receptor in cartilage. PPARgamma activation modulates the effects of interleukin-1beta on rat chondrocytes.

Bordji K, Grillasca JP, Gouze JN, Magdalou J, Schohn H, Keller JM, Bianchi A, Dauça M, Netter P, Terlain B

J. Biol. Chem.. 2000 Apr;275(16):12243-50

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