Détail - canceropole-wordpress

The dual life of disordered lysine-rich domains of snoRNPs in rRNA modification and nucleolar compaction.

Dominique C, Maiga NK, Méndez-Godoy A, Pillet B, Hamze H, Léger-Silvestre I, Henry Y, Marchand V, Gomes Neto V, Dez C, Motorin Y, Kressler D, Gadal O, Henras AK, Albert B

Nat Commun. 2024 10 31;15(1):9415

Differential redox sensitivity of tRNA dihydrouridylation.

Kilz LM, Zimmermann S, Marchand V, Bourguignon V, Sudol C, Brégeon D, Hamdane D, Motorin Y, Helm M

Nucleic Acids Res. 2024 10 26;:

A DNA Polymerase Variant Senses the Epigenetic Marker 5-Methylcytosine by Increased Misincorporation.

Henkel M, Fillbrunn A, Marchand V, Raghunathan G, Berthold MR, Motorin Y, Marx A

Angew Chem Int Ed Engl. 2024 10 24;:e202413304

Selective RNA pseudouridinylation in situ by circular gRNAs in designer organelles.

Schartel L, Jann C, Wierczeiko A, Butto T, Mündnich S, Marchand V, Motorin Y, Helm M, Gerber S, Lemke EA

Nat Commun. 2024 10 24;15(1):9177

DORQ-seq: high-throughput quantification of femtomol tRNA pools by combination of cDNA hybridization and Deep sequencing.

Kristen M, Lander M, Kilz LM, Gleue L, Jörg M, Bregeon D, Hamdane D, Marchand V, Motorin Y, Friedland K, Helm M

Nucleic Acids Res. 2024 10 14;52(18):e89

Exploring a unique class of flavoenzymes: Identification and biochemical characterization of ribosomal RNA dihydrouridine synthase.

Toubdji S, Thullier Q, Kilz LM, Marchand V, Yuan Y, Sudol C, Goyenvalle C, Jean-Jean O, Rose S, Douthwaite S, Hardy L, Baharoglu Z, de Crécy-Lagard V, Helm M, Motorin Y, Hamdane D, Brégeon D

Proc Natl Acad Sci U S A. 2024 08 6;121(32):e2401981121

TGF-β2 Induces Ribosome Activity, Alters Ribosome Composition and Inhibits IRES-Mediated Translation in Chondrocytes.

van den Akker GGH, Chabronova A, Housmans BAC, van der Vloet L, Surtel DAM, Cremers A, Marchand V, Motorin Y, Caron MMJ, Peffers MJ, Welting TJM

Int J Mol Sci. 2024 05 5;25(9):

Functional redundancy in tRNA dihydrouridylation.

Sudol C, Kilz LM, Marchand V, Thullier Q, Guérineau V, Goyenvalle C, Faivre B, Toubdji S, Lombard M, Jean-Jean O, de Crécy-Lagard V, Helm M, Motorin Y, Brégeon D, Hamdane D

Nucleic Acids Res. 2024 04 29;:

Mapping the tRNA modification landscape of Houston I and Toulouse.

Quaiyum S, Sun J, Marchand V, Sun G, Reed CJ, Motorin Y, Dedon PC, Minnick MF, de Crécy-Lagard V

Front Microbiol. 2024 03 13;15:1369018

Comprehensive map of ribosomal 2'-O-methylation and C/D box snoRNAs in Drosophila melanogaster.

Sklias A, Cruciani S, Marchand V, Spagnuolo M, Lavergne G, Bourguignon V, Brambilla A, Dreos R, Marygold SJ, Novoa EM, Motorin Y, Roignant JY

Nucleic Acids Res. 2024 02 28;:

N1-methylation of adenosine (mA) in ND5 mRNA leads to complex I dysfunction in Alzheimer's disease.

Jörg M, Plehn JE, Kristen M, Lander M, Walz L, Lietz C, Wijns J, Pichot F, Rojas-Charry L, Wirtz Martin KM, Ruffini N, Kreim N, Gerber S, Motorin Y, Endres K, Rossmanith W, Methner A, Helm M, Friedland K

Mol Psychiatry. 2024 01 29;:

Advances in methods for tRNA sequencing and quantification.

Padhiar NH, Katneni U, Komar AA, Motorin Y, Kimchi-Sarfaty C

Trends Genet. 2023 12 19;:

General Principles and Limitations for Detection of RNA Modifications by Sequencing.

Motorin Y, Helm M

Acc Chem Res. 2023 12 8;:

Depletion of Abolishes ψ of 28S-U4966 and Affects the Ribosome Translational Apparatus.

Chabronova A, van den Akker G, Housmans BAC, Caron MMJ, Cremers A, Surtel DAM, Peffers MJ, van Rhijn LW, Marchand V, Motorin Y, Welting TJM

Int J Mol Sci. 2023 08 8;24(16):

METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer.

García-Vílchez R, Añazco-Guenkova AM, Dietmann S, López J, Morón-Calvente V, D'Ambrosi S, Nombela P, Zamacola K, Mendizabal I, García-Longarte S, Zabala-Letona A, Astobiza I, Fernández S, Paniagua A, Miguel-López B, Marchand V, Alonso-López D, Merkel A, García-Tuñón I, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Azkargorta M, Elortza F, Bárcena L, Gonzalez-Lopez M, Aransay AM, Di Domenico T, Sánchez-Martín MA, De Las Rivas J, Guil S, Motorin Y, Helm M, Pandolfi PP, Carracedo A, Blanco S

Mol Cancer. 2023 07 29;22(1):119

nicotianamine synthase activity affects nucleolar iron accumulation and impacts rDNA silencing and RNA methylation in Arabidopsis.

Montacié C, Riondet C, Wei L, Darriere T, Weiss A, Pontvianne F, Escande ML, de Bures A, Jobet E, Barbarossa A, Carpentier MC, Aarts MGM, Attina A, Hirtz C, David A, Marchand V, Motorin Y, Curie C, Mari S, Reichheld JP, Sáez-Vásquez J

J Exp Bot. 2023 05 14;:

Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing.

Lucas MC, Pryszcz LP, Medina R, Milenkovic I, Camacho N, Marchand V, Motorin Y, Ribas de Pouplana L, Novoa EM

Nat Biotechnol. 2023 04 6;:

The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance.

Brazane M, Dimitrova DG, Pigeon J, Paolantoni C, Ye T, Marchand V, Da Silva B, Schaefer E, Angelova MT, Stark Z, Delatycki M, Dudding-Byth T, Gecz J, Plaçais PY, Teysset L, Préat T, Piton A, Hassan BA, Roignant JY, Motorin Y, Carré C

Life Sci Alliance. 2023 04;6(4):

A dual-purpose polymerase engineered for direct sequencing of pseudouridine and queuosine.

Huber LB, Kaur N, Henkel M, Marchand V, Motorin Y, Ehrenhofer-Murray AE, Marx A

Nucleic Acids Res. 2023 03 27;:

FUS regulates a subset of snoRNA expression and modulates the level of rRNA modifications.

Gawade K, Plewka P, Häfner SJ, Lund AH, Marchand V, Motorin Y, Szczesniak MW, Raczynska KD

Sci Rep. 2023 02 20;13(1):2974

Ribosomal RNA-based epitranscriptomic regulation of chondrocyte translation and proteome in osteoarthritis.

Chabronova A, van den Akker GGH, Housmans BAC, Caron MMJ, Cremers A, Surtel DAM, Wichapong K, Peffers MMJ, van Rhijn LW, Marchand V, Motorin Y, Welting TJM

Osteoarthritis Cartilage. 2023 01 5;:

Data Analysis Pipeline for Detection and Quantification of Pseudouridine (ψ) in RNA by HydraPsiSeq.

Pichot F, Marchand V, Helm M, Motorin Y

Methods Mol Biol. 2023 ;2624:207-223

Quantification of substoichiometric modification reveals global tsRNA hypomodification, preferences for angiogenin-mediated tRNA cleavage, and idiosyncratic epitranscriptomes of human neuronal cell-lines.

Pichot F, Hogg MC, Marchand V, Bourguignon V, Jirström E, Farrell C, Gibriel HA, Prehn JHM, Motorin Y, Helm M

Comput Struct Biotechnol J. 2022 12 19;21:401-417

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA.

Maharana S, Kretschmer S, Hunger S, Yan X, Kuster D, Traikov S, Zillinger T, Gentzel M, Elangovan S, Dasgupta P, Chappidi N, Lucas N, Maser KI, Maatz H, Rapp A, Marchand V, Chang YT, Motorin Y, Hubner N, Hartmann G, Hyman AA, Alberti S, Lee-Kirsch MA

Mol Cell. 2022 09 16;:

Pseudouridylation of Epstein-Barr Virus Noncoding RNA EBER2 Facilitates Lytic Replication.

Henry BA, Marchand V, Schlegel BT, Helm M, Motorin Y, Lee N

RNA. 2022 09 13;:

Synthesis of point-modified mRNA.

Hertler J, Slama K, Schober B, Özrendeci Z, Marchand V, Motorin Y, Helm M

Nucleic Acids Res. 2022 09 5;:

Studies of mutations of assembly factor Hit 1 in budding yeast suggest translation defects as the molecular basis for PEHO syndrome.

Dreggors-Walker RE, Cohen LN, Khoshnevis S, Marchand V, Motorin Y, Ghalei H

J Biol Chem. 2022 07 14;:102261

Dihydrouridine in the Transcriptome: New Life for This Ancient RNA Chemical Modification.

Brégeon D, Pecqueur L, Toubdji S, Sudol C, Lombard M, Fontecave M, de Crécy-Lagard V, Motorin Y, Helm M, Hamdane D

ACS Chem Biol. 2022 06 23;:

Phosphorylation found inside RNA.

Helm M, Motorin Y

Nature. 2022 Apr 27;:

Ribosomal RNA 2'--methylations regulate translation by impacting ribosome dynamics.

Khoshnevis S, Dreggors-Walker RE, Marchand V, Motorin Y, Ghalei H

Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2117334119

Machine learning algorithm for precise prediction of 2'-O-methylation (Nm) sites from experimental RiboMethSeq datasets.

Pichot F, Marchand V, Helm M, Motorin Y

Methods. 2022 Mar 18;:

Systematic mapping of rRNA 2'-O methylation during frog development and involvement of the methyltransferase Fibrillarin in eye and craniofacial development in Xenopus laevis.

Delhermite J, Tafforeau L, Sharma S, Marchand V, Wacheul L, Lattuca R, Desiderio S, Motorin Y, Bellefroid E, Lafontaine DLJ

PLoS Genet. 2022 Jan 18;18(1):e1010012

RNA nucleotide methylation: 2021 update.

Motorin Y, Helm M

Wiley Interdiscip Rev RNA. 2021 Dec 15;:e1691

Balancing of mitochondrial translation through METTL8-mediated mC modification of mitochondrial tRNAs.

Schöller E, Marks J, Marchand V, Bruckmann A, Powell CA, Reichold M, Mutti CD, Dettmer K, Feederle R, Hüttelmaier S, Helm M, Oefner P, Minczuk M, Motorin Y, Hafner M, Meister G

Mol Cell. 2021 Nov 8;:

General Principles for the Detection of Modified Nucleotides in RNA by Specific Reagents.

Helm M, Schmidt-Dengler MC, Weber M, Motorin Y

Adv Biol (Weinh). 2021 Sep 17;:e2100866

Constitutive and variable 2'-O-methylation (Nm) in human ribosomal RNA.

Motorin Y, Quinternet M, Rhalloussi W, Marchand V

RNA Biol. 2021 Sep 10;:1-10

Analysis of pseudouridines and other RNA modifications using hydraPsiSeq protocol.

Marchand V, Bourguignon-Igel V, Helm M, Motorin Y

Methods. 2021 Sep 1;:

Implication of repeat insertion domains in the trans-activity of the long non-coding RNA ANRIL.

Alfeghaly C, Sanchez A, Rouget R, Thuillier Q, Igel-Bourguignon V, Marchand V, Branlant C, Motorin Y, Behm-Ansmant I, Maenner S

Nucleic Acids Res. 2021 Apr 19;:

Detection and functions of viral RNA modifications: perspectives in biology and medicine.

Marchand V, Motorin Y

Virologie (Montrouge). 2021 Apr 1;25(2):5-20

[Detection and functions of viral RNA modifications: perspectives in biology and medicine].

Marchand V, Motorin Y

Virologie (Montrouge). 2021 Apr 1;25(2):93-110

FTO-mediated cytoplasmic mA demethylation adjusts stem-like properties in colorectal cancer cell.

Relier S, Ripoll J, Guillorit H, Amalric A, Achour C, Boissière F, Vialaret J, Attina A, Debart F, Choquet A, Macari F, Marchand V, Motorin Y, Samalin E, Vasseur JJ, Pannequin J, Aguilo F, Lopez-Crapez E, Hirtz C, Rivals E, Bastide A, David A

Nat Commun. 2021 Mar 19;12(1):1716

Mapping rRNA 2'-O-methylations and identification of C/D snoRNAs in Arabidopsis thaliana plants.

Azevedo-Favory J, Gaspin C, Ayadi L, Montacié C, Marchand V, Jobet E, Rompais M, Carapito C, Motorin Y, Sáez-Vásquez J

RNA Biol. 2021 Feb 17;:1-18

Analysis of RNA Modifications by Second- and Third-Generation Deep Sequencing: 2020 Update.

Motorin Y, Marchand V

Genes (Basel). 2021 Feb 16;12(2):

Cell culture NAIL-MS allows insight into human tRNA and rRNA modification dynamics in vivo.

Heiss M, Hagelskamp F, Marchand V, Motorin Y, Kellner S

Nat Commun. 2021 Jan 15;12(1):389

Non-Redundant tRNA Reference Sequences for Deep Sequencing Analysis of tRNA Abundance and Epitranscriptomic RNA Modifications.

Pichot F, Marchand V, Helm M, Motorin Y

Genes (Basel). 2021 Jan 10;12(1):

Isolation, Extraction and Deep-Sequencing Analysis of Extracellular RNAs (exRNAs) from Human Plasma.

Marchand V, Galvanin A, Motorin Y

Methods Mol Biol. 2021 ;2300:165-182

Mapping of 7-methylguanosine (mG), 3-methylcytidine (mC), dihydrouridine (D) and 5-hydroxycytidine (hoC) RNA modifications by AlkAniline-Seq.

Marchand V, Bourguignon-Igel V, Helm M, Motorin Y

Methods Enzymol. 2021 ;658:25-47

Quantitative and Qualitative Assessment of Small RNA Preparations.

Marchand V, Ayadi L, Bourguignon-Igel V, Motorin Y

Methods Mol Biol. 2021 ;2300:17-29

NOseq: amplicon sequencing evaluation method for RNA m6A sites after chemical deamination.

Werner S, Galliot A, Pichot F, Kemmer T, Marchand V, Sednev MV, Lence T, Roignant JY, König J, Höbartner C, Motorin Y, Hildebrandt A, Helm M

Nucleic Acids Res. 2020 Dec 11;:

Bacterial tRNA 2'-O-methylation is dynamically regulated under stress conditions and modulates innate immune response.

Galvanin A, Vogt LM, Grober A, Freund I, Ayadi L, Bourguignon-Igel V, Bessler L, Jacob D, Eigenbrod T, Marchand V, Dalpke A, Helm M, Motorin Y

Nucleic Acids Res. 2020 Dec 4;:

Ribosomal RNA 2'O-methylation as a novel layer of inter-tumour heterogeneity in breast cancer.

Marcel V, Kielbassa J, Marchand V, Natchiar KS, Paraqindes H, Nguyen Van Long F, Ayadi L, Bourguignon-Igel V, Lo Monaco P, Monchiet D, Scott V, Tonon L, Bray SE, Diot A, Jordan LB, Thompson AM, Bourdon JC, Dubois T, André F, Catez F, Puisieux A, Motorin Y, Klaholz BP, Viari A, Diaz JJ

NAR Cancer. 2020 Dec;2(4):zcaa036

HydraPsiSeq: a method for systematic and quantitative mapping of pseudouridines in RNA.

Marchand V, Pichot F, Neybecker P, Ayadi L, Bourguignon-Igel V, Wacheul L, Lafontaine DLJ, Pinzano A, Helm M, Motorin Y

Nucleic Acids Res.. 2020 Sep 25;:

Manganese Ions Individually Alter the Reverse Transcription Signature of Modified Ribonucleosides.

Kristen M, Plehn J, Marchand V, Friedland K, Motorin Y, Helm M, Werner S

Genes (Basel). 2020 Aug 18;11(8):

Survey and Validation of tRNA Modifications and Their Corresponding Genes in sp Subtilis Strain 168.

de Crécy-Lagard V, Ross RL, Jaroch M, Marchand V, Eisenhart C, Brégeon D, Motorin Y, Limbach PA

Biomolecules. 2020 Jun 30;10(7):

2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations.

Trzaska C, Amand S, Bailly C, Leroy C, Marchand V, Duvernois-Berthet E, Saliou JM, Benhabiles H, Werkmeister E, Chassat T, Guilbert R, Hannebique D, Mouray A, Copin MC, Moreau PA, Adriaenssens E, Kulozik A, Westhof E, Tulasne D, Motorin Y, Rebuffat S, Lejeune F

Nat Commun. 2020 Mar 20;11(1):1509

Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes.

Werner S, Schmidt L, Marchand V, Kemmer T, Falschlunger C, Sednev MV, Bec G, Ennifar E, Höbartner C, Micura R, Motorin Y, Hildebrandt A, Helm M

Nucleic Acids Res.. 2020 Feb 25;:

tRNA 2'-O-methylation by a duo of TRM7/FTSJ1 proteins modulates small RNA silencing in Drosophila.

Angelova MT, Dimitrova DG, Da Silva B, Marchand V, Jacquier C, Achour C, Brazane M, Goyenvalle C, Bourguignon-Igel V, Shehzada S, Khouider S, Lence T, Guerineau V, Roignant JY, Antoniewski C, Teysset L, Bregeon D, Motorin Y, Schaefer MR, Carré C

Nucleic Acids Res.. 2020 Jan 16;:

Holistic Optimization of Bioinformatic Analysis Pipeline for Detection and Quantification of 2'-O-Methylations in RNA by RiboMethSeq.

Pichot F, Marchand V, Ayadi L, Bourguignon-Igel V, Helm M, Motorin Y

Front Genet. 2020 ;11:38

Limited antibody specificity compromises epitranscriptomic analyses.

Helm M, Lyko F, Motorin Y

Nat Commun. 2019 Dec 11;10(1):5669

"RNA structure, maturation, interactions and functions".

Motorine Y, Massenet S

Biochimie. 2019 Jul 17;:

Diversity and heterogeneity of extracellular RNA in human plasma.

Galvanin A, Dostert G, Ayadi L, Marchand V, Velot É, Motorin Y

Biochimie. 2019 May 17;:

2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms.

Freund I, Buhl DK, Boutin S, Kotter A, Pichot F, Marchand V, Vierbuchen T, Heine H, Motorin Y, Helm M, Dalpke AH, Eigenbrod T

RNA. 2019 Apr 24;:

Absolute quantification of noncoding RNA by microscale thermophoresis.

Jacob D, Thüring K, Galliot A, Marchand V, Galvanin A, Ciftci A, Scharmann K, Stock M, Roignant JY, Leidel SA, Motorin Y, Schaffrath R, Klassen R, Helm M

Angew. Chem. Int. Ed. Engl.. 2019 Mar 20;:

FTSJ3 is an RNA 2'-O-methyltransferase recruited by HIV to avoid innate immune sensing.

Ringeard M, Marchand V, Decroly E, Motorin Y, Bennasser Y

Nature. 2019 Jan 9;:

Methods for RNA Modification Mapping Using Deep Sequencing: Established and New Emerging Technologies.

Motorin Y, Helm M

Genes (Basel). 2019 Jan 9;10(1):

Graphical Workflow System for Modification Calling by Machine Learning of Reverse Transcription Signatures.

Schmidt L, Werner S, Kemmer T, Niebler S, Kristen M, Ayadi L, Johe P, Marchand V, Schirmeister T, Motorin Y, Hildebrandt A, Schmidt B, Helm M

Front Genet. 2019 ;10:876

Mapping and Quantification of tRNA 2'-O-Methylation by RiboMethSeq.

Galvanin A, Ayadi L, Helm M, Motorin Y, Marchand V

Methods Mol. Biol.. 2019 ;1870:273-295

Detection and Analysis of RNA Ribose 2'-O-Methylations: Challenges and Solutions.

Motorin Y, Marchand V

Genes (Basel). 2018 Dec 18;9(12):

RNA ribose methylation (2'-O-methylation): Occurrence, biosynthesis and biological functions.

Ayadi L, Galvanin A, Pichot F, Marchand V, Motorin Y

Biochim Biophys Acta Gene Regul Mech. 2018 Dec 17;:

AlkAniline-Seq: profiling of m7G and m3C RNA modifications at single nucleotide resolution.

Marchand V, Ayadi L, Ernst FGM, Hertler J, Bourguignon-Igel V, Galvanin A, Kotter A, Helm M, Lafontaine DLJ, Motorin Y

Angew. Chem. Int. Ed. Engl.. 2018 Oct 29;:

Contribution of protein Gar1 to the RNA-guided and RNA-independent rRNA:Ψ-synthase activities of the archaeal Cbf5 protein.

Fujikane R, Behm-Ansmant I, Tillault AS, Loegler C, Igel-Bourguignon V, Marguet E, Forterre P, Branlant C, Motorin Y, Charpentier B

Sci Rep. 2018 Sep 14;8(1):13815

Double methylation of tRNA-U54 to 2'-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7.

Keller P, Freund I, Marchand V, Bec G, Huang R, Motorin Y, Eigenbrod T, Dalpke A, Helm M

Nucleic Acids Res.. 2018 Aug 8;:

A Vastly Increased Chemical Variety of RNA Modifications Containing a Thioacetal Structure.

Dal Magro C, Keller P, Kotter A, Werner S, Duarte V, Marchand V, Ignarski M, Freiwald A, Müller RU, Dieterich C, Motorin Y, Butter F, Atta M, Helm M

Angew. Chem. Int. Ed. Engl.. 2018 Apr 6;:

Positioning Europe for the EPITRANSCRIPTOMICS challenge.

Jantsch MF, Quattrone A, O'Connell M, Helm M, Frye M, Macias-Gonzales M, Ohman M, Ameres S, Willems L, Fuks F, Oulas A, Vanacova S, Nielsen H, Bousquet-Antonelli C, Motorin Y, Roignant JY, Balatsos N, Dinnyes A, Baranov P, Kelly V, Lamm A, Rechavi G, Pelizzola M, Liepins J, Holodnuka Kholodnyuk I, Zammit V, Ayers D, Drablos F, Dahl JA, Bujnicki J, Jeronimo C, Almeida R, Neagu M, Costache M, Bankovic J, Banovic B, Kyselovic J, Valor LM, Selbert S, Pir P, Demircan T, Cowling V, Schäfer M, Rossmanith W, Lafontaine D, David A, Carre C, Lyko F, Schaffrath R, Schwartz S, Verdel A, Klungland A, Purta E, Timotijevic G, Cardona F, Davalos A, Ballana E, O Carroll D, Ule J, Fray R

RNA Biol. 2018 ;15(6):829-831

Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120.

Bourgeois G, Ney M, Gaspar I, Aigueperse C, Schaefer M, Kellner S, Helm M, Motorin Y

PLoS ONE. 2015 ;10(7):e0133321

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