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Publications
BIN1 reduction ameliorates -related Charcot-Marie-Tooth neuropathy.
Goret M, Thomas M, Edelweiss E, Messaddeq N, Laporte J
Proc Natl Acad Sci U S A. 2025 03 11;122(10):e2419244122
Experimental myositis: an optimised version of C-protein-induced myositis.
Giannini M, Rovito D, Oulad-Abdelghani M, Messaddeq N, Debrut L, Quiring G, Kessler P, Charles AL, Geny B, Metzger D, Laverny G, Meyer A
RMD Open. 2025 03 5;11(1):
MTM1 overexpression prevents and reverts BIN1-related centronuclear myopathy.
Giraud Q, Spiegelhalter C, Messaddeq N, Laporte J
Brain. 2023 07 25;:
Androgen receptor coordinates muscle metabolic and contractile functions.
Ghaibour K, Schuh M, Souali-Crespo S, Chambon C, Charlot A, Rizk J, Rovito D, Rerra AI, Cai Q, Messaddeq N, Zoll J, Duteil D, Metzger D
J Cachexia Sarcopenia Muscle. 2023 05 20;:
Polyglutamine-expanded ATXN7 alters a specific epigenetic signature underlying photoreceptor identity gene expression in SCA7 mouse retinopathy.
Niewiadomska-Cimicka A, Hache A, Le Gras S, Keime C, Ye T, Eisenmann A, Harichane I, Roux MJ, Messaddeq N, Clérin E, Léveillard T, Trottier Y
J Biomed Sci. 2022 12 20;29(1):107
Differential impact of ubiquitous and muscle dynamin 2 isoforms in muscle physiology and centronuclear myopathy.
Gómez-Oca R, Edelweiss E, Djeddi S, Gerbier M, Massana-Muñoz X, Oulad-Abdelghani M, Crucifix C, Spiegelhalter C, Messaddeq N, Poussin-Courmontagne P, Koebel P, Cowling BS, Laporte J
Nat Commun. 2022 11 11;13(1):6849
PATAS, a First-in-Class Therapeutic Peptide Biologic, Improves Whole-Body Insulin Resistance and Associated Comorbidities In Vivo.
Schreyer E, Obringer C, Messaddeq N, Kieffer B, Zimmet P, Fleming A, Geberhiwot T, Marion V
Diabetes. 2022 07 13;:
BIN1 modulation in vivo rescues dynamin-related myopathy.
Lionello VM, Kretz C, Edelweiss E, Crucifix C, Gómez-Oca R, Messaddeq N, Buono S, Koebel P, Massana Muñoz X, Diedhiou N, Cowling BS, Bitoun M, Laporte J
Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):
In Vitro Fertilization assisted by IntraCytoplasmic Sperm Injection in a male patient with Bardet-Biedl syndrome.
Grèze C, Muller J, Schindler L, Rossignol S, Messaddeq N, Zinetti-Bertschy A, Goetz N, Dollfus H, Koscinski I
Clin Genet. 2022 Feb 17;:
Cardiac forces regulate zebrafish heart valve delamination by modulating Nfat signaling.
Chow RW, Fukui H, Chan WX, Tan KSJ, Roth S, Duchemin AL, Messaddeq N, Nakajima H, Liu F, Faggianelli-Conrozier N, Klymchenko AS, Choon Hwai Y, Mochizuki N, Vermot J
PLoS Biol. 2022 Jan 14;20(1):e3001505
Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection.
Ferren M, Favède V, Decimo D, Iampietro M, Lieberman NAP, Weickert JL, Pelissier R, Mazelier M, Terrier O, Moscona A, Porotto M, Greninger AL, Messaddeq N, Horvat B, Mathieu C
Nat Commun. 2021 10 4;12(1):5809
Mice with muscle-specific deletion of Bin1 recapitulate centronuclear myopathy and acute downregulation of dynamin 2 improves their phenotypes.
Silva-Rojas R, Nattarayan V, Jaque-Fernandez F, Gomez-Oca R, Menuet A, Reiss D, Goret M, Messaddeq N, Lionello VM, Kretz C, Cowling BS, Jacquemond V, Laporte J
Mol Ther. 2021 Aug 6;:
SCA7 mouse cerebellar pathology reveals preferential downregulation of key Purkinje cell-identity genes and shared disease signature with SCA1 and SCA2.
Niewiadomska-Cimicka A, Doussau F, Perot JB, Roux MJ, Keime C, Hache A, Piguet F, Novati A, Weber C, Yalcin B, Meziane H, Champy MF, Grandgirard E, Karam A, Messaddeq N, Eisenmann A, Brouillet E, Nguyen HHP, Flament J, Isope P, Trottier Y
J Neurosci. 2021 Apr 16;:
Tunable functionalization of nano-emulsions using amphiphilic polymers.
Rehman AU, Anton N, Bou S, Schild J, Messaddeq N, Vandamme T, Akram S, Klymchenko A, Collot M
Soft Matter. 2021 Jan 5;:
High Levels of Frataxin Overexpression Lead to Mitochondrial and Cardiac Toxicity in Mouse Models.
Belbellaa B, Reutenauer L, Messaddeq N, Monassier L, Puccio H
Mol Ther Methods Clin Dev. 2020 Dec 11;19:120-138
Relative Adipose Tissue Failure in Alström Syndrome Drives Obesity-Induced Insulin Resistance.
Geberhiwot T, Baig S, Obringer C, Girard D, Dawson C, Manolopoulos K, Messaddeq N, Lassen PB, Clement K, Tomlinson JW, Steeds RP, Dollfus H, Petrovsky N, Marion V
Diabetes. 2020 Sep 29;:
Intraoperative imaging for remnant viability assessment in bilateral posterior retroperitoneoscopic partial adrenalectomy in an experimental model.
Seeliger B, Alesina PF, Walz MK, Pop R, Charles AL, Geny B, Messaddeq N, Kontogeorgos G, Mascagni P, Seyller E, Marescaux J, Agnus V, Diana M
Br J Surg. 2020 Sep 1;:
Reproduction Function in Male Patients with Bardet Biedl Syndrome.
Koscinski I, Mark M, Messaddeq N, Braun JJ, Celebi C, Muller J, Zinnetti-Bertschy A, Goetz N, Dollfus H, Rossignol S
J. Clin. Endocrinol. Metab.. 2020 Aug 25;:
Pickering nano-emulsions stabilized by Eudragit RL100 nanoparticles as oral drug delivery system for poorly soluble drugs.
Dieng SM, Omran Z, Anton N, Thioune O, Djiboune AR, Sy PM, Messaddeq N, Ennahar S, Diarra M, Vandamme T
Colloids Surf B Biointerfaces. 2020 Apr 18;191:111010
FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis.
Picchiarelli G, Demestre M, Zuko A, Been M, Higelin J, Dieterlé S, Goy MA, Mallik M, Sellier C, Scekic-Zahirovic J, Zhang L, Rosenbohm A, Sijlmans C, Aly A, Mersmann S, Sanjuan-Ruiz I, Hübers A, Messaddeq N, Wagner M, van Bakel N, Boutillier AL, Ludolph A, Lagier-Tourenne C, Boeckers TM, Dupuis L, Storkebaum E
Nat. Neurosci.. 2019 Oct 7;:
In vivo phenotypic and molecular characterization of retinal degeneration in mouse models of three ciliopathies.
Brun A, Yu X, Obringer C, Ajoy D, Haser E, Stoetzel C, Roux MJ, Messaddeq N, Dollfus H, Marion V
Exp. Eye Res.. 2019 Jul 11;:107721
Amphiphysin 2 modulation rescues myotubular myopathy and prevents focal adhesion defects in mice.
Lionello VM, Nicot AS, Sartori M, Kretz C, Kessler P, Buono S, Djerroud S, Messaddeq N, Koebel P, Prokic I, Hérault Y, Romero NB, Laporte J, Cowling BS
Sci Transl Med. 2019 Mar 20;11(484):
Towards the formulation of stable micro and nano double emulsions through silica coating of internal water droplets.
Akram S, Wang X, Vandamme TF, Collot M, Rehman AU, Messaddeq N, Mély Y, Anton N
Langmuir. 2019 Jan 10;:
Magnetite- and Iodine-Containing Nanoemulsion as a Dual Modal Contrast Agent for X-ray/Magnetic Resonance Imaging.
Wallyn J, Anton N, Mertz D, Begin-Colin S, Perton F, Serra CA, Franconi F, Lemaire L, Chiper M, Libouban H, Messaddeq N, Anton H, Vandamme TF
ACS Appl Mater Interfaces. 2019 Jan 9;11(1):403-416
STIM1 over-activation generates a multi-systemic phenotype affecting skeletal muscle, spleen, eye, skin, bones, and the immune system in mice.
Silva-Rojas R, Treves S, Jacobs H, Kessler P, Messaddeq N, Laporte J, Böhm J
Hum. Mol. Genet.. 2018 Dec 21;:
Abnormal lipid storage related to adipocyte shrinkage in acquired partial lipodystrophy (Barraquer-Simons syndrome).
Velter C, Messaddeq N, Levy E, Morruzzi C, Cribier B, Dali-Youcef N, Lipsker D
J Eur Acad Dermatol Venereol. 2018 Nov 25;:
Loss of zebrafish Ataxin-7, a SAGA subunit responsible for SCA7 retinopathy, causes ocular coloboma and malformation of photoreceptors.
Carrillo-Rosas S, Weber C, Fievet L, Messaddeq N, Karam A, Trottier Y
Hum. Mol. Genet.. 2018 Nov 16;:
Pickering nano-emulsion as a nanocarrier for pH-triggered drug release.
Sy PM, Anton N, Idoux-Gillet Y, Dieng SM, Messaddeq N, Ennahar S, Diarra M, Vandamme TF
Int J Pharm. 2018 Jul 31;:
Single Intramuscular Injection of AAV-shRNA Reduces DNM2 and Prevents Myotubular Myopathy in Mice.
Tasfaout H, Lionello VM, Kretz C, Koebel P, Messaddeq N, Bitz D, Laporte J, Cowling BS
Mol. Ther.. 2018 Apr 4;26(4):1082-1092
Microfluidic-Assisted Production of Size-Controlled Superparamagnetic Iron Oxide Nanoparticles-Loaded Poly(methyl methacrylate) Nanohybrids.
Ding S, Attia MF, Wallyn J, Taddei C, Serra CA, Anton N, Kassem M, Schmutz M, Er-Rafik M, Messaddeq N, Collard A, Yu W, Giordano M, Vandamme TF
Langmuir. 2018 02 6;34(5):1981-1991
The MTM1-UBQLN2-HSP complex mediates degradation of misfolded intermediate filaments in skeletal muscle.
Gavriilidis C, Laredj L, Solinhac R, Messaddeq N, Viaud J, Laporte J, Sumara I, Hnia K
Nat. Cell Biol.. 2018 Feb;20(2):198-210
A new formulation of poly(MAOTIB) nanoparticles as an efficient contrast agent for in vivo X-ray imaging.
Wallyn J, Anton N, Serra CA, Bouquey M, Collot M, Anton H, Weickert JL, Messaddeq N, Vandamme TF
Acta Biomater. 2018 01 15;66:200-212
Modulation of large dense core vesicle insulin content mediates rhythmic hormone release from pancreatic beta cells over the 24h cycle.
Quinault A, Leloup C, Denwood G, Spiegelhalter C, Rodriguez M, Lefebvre P, Messaddeq N, Zhang Q, Dacquet C, Pénicaud L, Collins SC
PLoS ONE. 2018 ;13(3):e0193882
Phagocytosis by Sertoli Cells: Analysis of Main Phagocytosis Steps by Confocal and Electron Microscopy.
Yefimova MG, Messaddeq N, Meunier AC, Cantereau A, Jegou B, Bourmeyster N
Methods Mol. Biol.. 2018 ;1748:85-101
The histone code reader Spin1 controls skeletal muscle development.
Greschik H, Duteil D, Messaddeq N, Willmann D, Arrigoni L, Sum M, Jung M, Metzger D, Manke T, Günther T, Schüle R
Cell Death Dis. 2017 Nov 23;8(11):e3173
Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development.
Li S, Teegarden A, Bauer EM, Choi J, Messaddeq N, Hendrix DA, Ganguli-Indra G, Leid M, Indra AK
Sci Rep. 2017 Oct 18;7(1):13427
Antisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice.
Tasfaout H, Buono S, Guo S, Kretz C, Messaddeq N, Booten S, Greenlee S, Monia BP, Cowling BS, Laporte J
Nat Commun. 2017 Jun 7;8:15661
ISCA1 is essential for mitochondrial FeS biogenesis in vivo.
Beilschmidt LK, Ollagnier de Choudens S, Fournier M, Sanakis I, Hograindleur MA, Clémancey M, Blondin G, Schmucker S, Eisenmann A, Weiss A, Koebel P, Messaddeq N, Puccio H, Martelli A
Nat Commun. 2017 May 11;8:15124
Well-organized spheroids as a new platform to examine cell interaction and behaviour during organ development.
Bécavin T, Kuchler-Bopp S, Kökten T, Huck O, Messaddeq N, Lesot H, Deveaux E, Benkirane-Jessel N, Laetitia K
Cell Tissue Res.. 2016 Dec;366(3):601-615
Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue.
Duteil D, Tosic M, Lausecker F, Nenseth HZ, Müller JM, Urban S, Willmann D, Petroll K, Messaddeq N, Arrigoni L, Manke T, Kornfeld JW, Brüning JC, Zagoriy V, Meret M, Dengjel J, Kanouni T, Schüle R
Cell Rep. 2016 10 18;17(4):1008-1021
Myelinosomes act as natural secretory organelles in Sertoli cells to prevent accumulation of aggregate-prone mutant Huntingtin and CFTR.
Yefimova MG, Béré E, Cantereau-Becq A, Harnois T, Meunier AC, Messaddeq N, Becq F, Trottier Y, Bourmeyster N
Hum. Mol. Genet.. 2016 10 1;25(19):4170-4185
One-step synthesis of iron oxide polypyrrole nanoparticles encapsulating ketoprofen as model of hydrophobic drug.
Attia MF, Anton N, Khan IU, Serra CA, Messaddeq N, Jakhmola A, Vecchione R, Vandamme T
Int J Pharm. 2016 Jul;508(1-2):61-70
Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier.
Villaseñor R, Ozmen L, Messaddeq N, Grüninger F, Loetscher H, Keller A, Betsholtz C, Freskgård PO, Collin L
Sci Rep. 2016 05 6;6:25658
Prokineticin receptor-1 signaling promotes Epicardial to Mesenchymal Transition during heart development.
Arora H, Boulberdaa M, Qureshi R, Bitirim V, Gasser A, Messaddeq N, Dolle P, Nebigil CG
Sci Rep. 2016 May;6:25541
Matrix metalloproteinase 11 protects from diabesity and promotes metabolic switch.
Dali-Youcef N, Hnia K, Blaise S, Messaddeq N, Blanc S, Postic C, Valet P, Tomasetto C, Rio MC
Sci Rep. 2016 Apr;6:25140
Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration.
Dubos A, Castells-Nobau A, Meziane H, Oortveld MA, Houbaert X, Iacono G, Martin C, Mittelhaeuser C, Lalanne V, Kramer JM, Bhukel A, Quentin C, Slabbert J, Verstreken P, Sigrist SJ, Messaddeq N, Birling MC, Selloum M, Stunnenberg HG, Humeau Y, Schenck A, Herault Y
Hum. Mol. Genet.. 2015 Dec;24(23):6736-55
The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defence in skeletal muscles.
Gali Ramamoorthy T, Laverny G, Schlagowski AI, Zoll J, Messaddeq N, Bornert JM, Panza S, Ferry A, Geny B, Metzger D
Nat Commun. 2015 Dec;6:10210
Microfluidic conceived Trojan microcarriers for oral delivery of nanoparticles.
Khan IU, Serra CA, Anton N, Er-Rafik M, Blanck C, Schmutz M, Kraus I, Messaddeq N, Sutter C, Anton H, Klymchenko AS, Vandamme TF
Int J Pharm. 2015 Sep 30;493(1-2):7-15
A novel function of Huntingtin in the cilium and retinal ciliopathy in Huntington's disease mice.
Karam A, Tebbe L, Weber C, Messaddeq N, Morlé L, Kessler P, Wolfrum U, Trottier Y
Neurobiol. Dis.. 2015 Aug;80:15-28
Developmental Alterations in Heart Biomechanics and Skeletal Muscle Function in Desmin Mutants Suggest an Early Pathological Root for Desminopathies.
Ramspacher C, Steed E, Boselli F, Ferreira R, Faggianelli N, Roth S, Spiegelhalter C, Messaddeq N, Trinh L, Liebling M, Chacko N, Tessadori F, Bakkers J, Laporte J, Hnia K, Vermot J
Cell Rep. 2015 Jun;11(10):1564-76
Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region.
Brault V, Duchon A, Romestaing C, Sahun I, Pothion S, Karout M, Borel C, Dembele D, Bizot JC, Messaddeq N, Sharp AJ, Roussel D, Antonarakis SE, Dierssen M, Hérault Y
PLoS Genet. 2015 03;11(3):e1005062
The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development.
Mlih M, Host L, Martin S, Niederhoffer N, Monassier L, Terrand J, Messaddeq N, Radke M, Gotthardt M, Bruban V, Kober F, Bernard M, Canet-Soulas E, Abt-Jijon F, Boucher P, Matz RL
J Biol Chem. 2015 Jan 23;290(4):2419-30
Biodistribution of X-ray iodinated contrast agent in nano-emulsions is controlled by the chemical nature of the oily core.
Attia MF, Anton N, Chiper M, Akasov R, Anton H, Messaddeq N, Fournel S, Klymchenko AS, Mely Y, Vandamme TF
ACS Nano. 2014 Oct 28;8(10):10537-50
Microfluidic conceived drug loaded Janus particles in side-by-side capillaries device.
Khan IU, Serra CA, Anton N, Li X, Akasov R, Messaddeq N, Kraus I, Vandamme TF
Int J Pharm. 2014 Oct 1;473(1-2):239-49
Poly-epsilon-caprolactone tungsten oxide nanoparticles as a contrast agent for X-ray computed tomography.
Jakhmola A, Anton N, Anton H, Messaddeq N, Hallouard F, Klymchenko A, Mely Y, Vandamme TF
Biomaterials. 2014 Mar;35(9):2981-6
Retinoic acid deficiency impairs the vestibular function.
Romand R, Krezel W, Beraneck M, Cammas L, Fraulob V, Messaddeq N, Kessler P, Hashino E, Dolle P
J Neurosci. 2013 Mar 27;33(13):5856-66
Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes.
Calleja C, Messaddeq N, Chapellier B, Yang H, Krezel W, Li M, Metzger D, Mascrez B, Ohta K, Kagechika H, Endo Y, Mark M, Ghyselinck NB, Chambon P
Genes Dev. 2006 Jun 1;20(11):1525-38.
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation.
Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J
Nature. 2006 Jan 26;439(7075):484-9
