Détail - canceropole-wordpress

Immunosuppressive drugs and diet interact to modify the gut microbiota and cardiovascular risk factors, and to trigger diabetes.

Gabarre P, Palacios R, Perez K, Seksik P, Bonnard B, Loens C, Lefranc C, de Barros JP, Anjou L, Tamzali Y, Zahr N, Jaisser F, Tourret J

PLoS One. 2025 03 28;20(3):e0320438

Cytomegalovirus infection of the fetal brain: intake of aspirin during pregnancy blunts neurodevelopmental pathogenesis in the offspring.

Tarhini S, Crespo-Quiles C, Buhler E, Pineau L, Pallesi-Pocachard E, Villain S, Saha S, Silvagnoli L, Stamminger T, Luche H, Cardoso C, Pais de Barros JP, Burnashev N, Szepetowski P, Bauer S

J Neuroinflammation. 2024 11 15;21(1):298

Impaired unsaturated fatty acid elongation alters mitochondrial function and accelerates metabolic dysfunction-associated steatohepatitis progression.

Vouilloz A, Bourgeois T, Diedisheim M, Pilot T, Jalil A, Le Guern N, Bergas V, Rohmer N, Castelli F, Leleu D, Varin A, de Barros JP, Degrace P, Rialland M, Blériot C, Venteclef N, Thomas C, Masson D

Metabolism. 2024 10 23;:156051

Association of Lipopolysaccharide-Type Endotoxins with Retinal Neurodegeneration: The Alienor Study.

Larsen PP, Féart C, Pais de Barros JP, Gayraud L, Delyfer MN, Korobelnik JF, Schweitzer C, Delcourt C

Ophthalmol Sci. 2024 08 28;5(1):100610

Risk factors and prognostic value of endotoxemia in patients with acute myocardial infarction.

Nguyen M, Putot A, Masson D, Cottin Y, Gautier T, Tribouillard L, Rérole AL, Guinot PG, Maza M, Pais de Barros JP, Deckert V, Farnier M, Lagrost L, Zeller M

Front Cardiovasc Med. 2024 06 25;11:1419001

Characterization of Silybum marianum and Silybum eburneum seed oils: Phytochemical profiles and antioxidant properties supporting important nutritional interests.

Maaloul S, Ghzaiel I, Mahmoudi M, Mighri H, Pires V, Vejux A, Martine L, de Barros JP, Prost-Camus E, Boughalleb F, Lizard G, Abdellaoui R

PLoS One. 2024 06 14;19(6):e0304021

VEGF-R2/CAV-1 Interaction Induced by Resveratrol/Eicosapentaenoic Acid/Docosahexaenoic Acid-Enriched Formulation through Functional Detergent-Resistant Membranes Is Associated with Decreased VEGF-A Release in ARPE-19 Cells.

Perus M, Courtaut F, Pais de Barros JP, Aires V, Hermetet F, Delmas D

Mol Nutr Food Res. 2024 05 19;:e2300893

Valrubicin-loaded immunoliposomes for specific vesicle-mediated cell death in the treatment of hematological cancers.

Georgievski A, Bellaye PS, Tournier B, Choubley H, Pais de Barros JP, Herbst M, Béduneau A, Callier P, Collin B, Végran F, Ballerini P, Garrido C, Quéré R

Cell Death Dis. 2024 05 11;15(5):328

Plasma 16:0 ceramide as a marker of cardiovascular risk estimated by carotid intima-media thickness in people with type 2 diabetes.

Denimal D, Duvillard L, Béland-Bonenfant S, Terriat B, Pais-de-Barros JP, Simoneau I, Rouland A, Houbachi L, Bouillet B, Vergès B, Petit JM

Diabetes Metab. 2024 05 4;:101542

No effect of liraglutide on high density lipoprotein apolipoprotein AI kinetics in patients with type 2 diabetes.

Duvillard L, de Barros JP, Rouland A, Simoneau I, Denimal D, Bouillet B, Petit JM, Vergès B

Diabetes Metab. 2024 04 21;:101535

Negative relationship between eicosapentaenoic acid and inflammatory biomarkers in patients with acute myocardial infarction.

Masson D, Leleu D, Farnier M, Chagué F, Rampon C, Bichat F, Demeule C, Maza M, Pais de Barros JP, Cottin Y, Zeller M

Cardiovasc Res. 2024 01 9;:

Plasma ceramides are associated with MRI-based liver fat content but not with noninvasive scores of liver fibrosis in patients with type 2 diabetes.

Denimal D, Béland-Bonenfant S, Pais-de-Barros JP, Rouland A, Bouillet B, Duvillard L, Vergès B, Petit JM

Cardiovasc Diabetol. 2023 11 8;22(1):310

Association of Age-Related Macular Degeneration with a Blood Biomarker of Lipopolysaccharide, a Gut Bacterial Proinflammatory Toxin.

Larsen PP, Féart C, Pais de Barros JP, Merle BMJ, Gayraud L, Delyfer MN, Korobelnik JF, Delcourt C

Invest Ophthalmol Vis Sci. 2023 11 1;64(14):47

Plasma citrulline concentration and plasma LPS detection among critically ill patients a prospective observational study.

Chaignat C, Lagrost L, Moretto K, de Barros JP, Winiszewski H, Grober J, Saas P, Piton G

J Crit Care. 2023 10 3;79:154438

Comparative Evaluation of Two Paclitaxel-Coated Stents in an Experimental Setting.

Pouhin A, Coscas R, Crespy V, Poupardin O, Pais-De-Barros JP, Bouchot O, Bernard A, Steinmetz E

J Endovasc Ther. 2023 09 20;:15266028231198033

Inflammation and oxidative stress markers in type 2 diabetes patients with Advanced Carotid atherosclerosis.

Ménégaut L, Laubriet A, Crespy V, Leleu D, Pilot T, Van Dongen K, de Barros JP, Gautier T, Petit JM, Thomas C, Nguyen M, Steinmetz E, Masson D

Cardiovasc Diabetol. 2023 09 14;22(1):248

Pneumococcal pneumonia and endotoxemia: An experimental and clinical reappraisal.

Godon J, Charles PE, Nguyen S, de Barros JP, Choubley H, Jacquier M, Tetu J, Quenot JP, Luu M, Binquet C, Masson D, Piroth L, Blot M,

Eur J Clin Invest. 2023 08 29;:e14077

Neurodegeneration, oxidative stress and lipid metabolism plasma biomarkers to differentiate Parkinson's disease from atypical parkinsonian syndromes.

Schneider V, Vejux A, Nury T, Dupont G, Pais de Barros JP, Lakomy D, Lizard G, Moreau T

Rev Neurol (Paris). 2023 06 14;:

Increased gut permeability and intestinal inflammation precede arthritis onset in the adjuvant-induced model of arthritis.

Hecquet S, Totoson P, Martin H, Algros MP, Saas P, Pais-de-Barros JP, Atchon A, Valot B, Hocquet D, Tournier M, Prati C, Wendling D, Demougeot C, Verhoeven F

Arthritis Res Ther. 2023 06 6;25(1):95

7β-hydroxycholesterol and 7-ketocholesterol: new oxidative stress biomarkers of sarcopenia inducing cytotoxic effects on myoblasts and myotubes.

Ghzaiel I, Zarrouk A, Pires V, de Barros JP, Hammami S, Ksila M, Hammami M, Ghrairi T, Jouanny P, Vejux A, Lizard G

J Steroid Biochem Mol Biol. 2023 06 5;:106345

Resolved psoriasis with abundant oleic acid in stratum corneum exhibits lower T-cell-driven IL-17 signature.

El Mahi Y, Varin A, Vetter M, Zuffo LD, Mazzeo L, Païs De Barros JP, Aubin F, Saas P, Sérézal IG

J Invest Dermatol. 2023 05 17;:

Liraglutide reduces plasma dihydroceramide levels in patients with type 2 diabetes.

Denimal D, Bergas V, Pais-de-Barros JP, Simoneau I, Demizieux L, Passilly-Degrace P, Bouillet B, Petit JM, Rouland A, Bataille A, Duvillard L, Vergès B

Cardiovasc Diabetol. 2023 05 4;22(1):104

Increased Weight Gain and Insulin Resistance in HF-Fed PLTP Deficient Mice Is Related to Altered Inflammatory Response and Plasma Transport of Gut-Derived LPS.

Lebrun LJ, Pallot G, Nguyen M, Tavernier A, Dusuel A, Pilot T, Deckert V, Dugail I, Le Guern N, Pais De Barros JP, Benkhaled A, Choubley H, Lagrost L, Masson D, Gautier T, Grober J

Int J Mol Sci. 2022 10 30;23(21):

Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-β receptors.

Kieu TL, Pierre L, Derangère V, Perrey S, Truntzer C, Jalil A, Causse S, Groetz E, Dumont A, Guyard L, Arnould L, de Barros JP, Apetoh L, Rébé C, Limagne E, Jourdan T, Demizieux L, Masson D, Thomas C, Ghiringhelli F, Rialland M

Cell Death Dis. 2022 09 2;13(9):758

Profiling of lipid mediators in atherosclerotic carotid plaques from type 2 diabetic and non-diabetic patients.

Ménégaut L, Laubriet A, Crespy V, Nguyen M, Petit JM, Tarris G, Pilot T, Varin A, Choubley H, Bergas V, de Barros JP, Thomas C, Steinmetz E, Masson D

Prostaglandins Leukot Essent Fatty Acids. 2022 08 4;184:102477

Identification of a Gain-of-Function Variant as a Novel Cause of Familial Combined Hypocholesterolemia.

Dijk W, Di Filippo M, Kooijman S, van Eenige R, Rimbert A, Caillaud A, Thedrez A, Arnaud L, Pronk A, Garçon D, Sotin T, Lindenbaum P, Garcia EO, Pais de Barros JP, Duvillard L, Si-Tayeb K, Amigo N, Le Questel JY, Rensen PCN, Le May C, Moulin P, Cariou B

Circulation. 2022 07 28;:101161CIRCULATIONAHA121057978

Lipidomic profiling of exosomes from colorectal cancer cells and patients reveals potential biomarkers.

Elmallah MIY, Ortega-Deballon P, Hermite L, Pais-De-Barros JP, Gobbo J, Garrido C

Mol Oncol. 2022 May 6;:

Acute lymphoblastic leukemia-derived extracellular vesicles affect quiescence of hematopoietic stem and progenitor cells.

Georgievski A, Michel A, Thomas C, Mlamla Z, Pais de Barros JP, Lemaire-Ewing S, Garrido C, Quéré R

Cell Death Dis. 2022 Apr 12;13(4):337

Chemical Synthesis, Pharmacokinetic Properties and Biological Effects of JM-00266, a Putative Non-Brain Penetrant Cannabinoid Receptor 1 Inverse Agonist.

Muller T, Demizieux L, Troy-Fioramonti S, Buch C, Leemput J, Belloir C, Pais de Barros JP, Jourdan T, Passilly-Degrace P, Fioramonti X, Le Bon AM, Vergès B, Robert JM, Degrace P

Int J Mol Sci. 2022 Mar 8;23(6):

HDL infusion protects from acute graft-versus-host disease in experimental allogeneic hematopoietic cell transplantation.

Chagué C, Gautier T, Dal Zuffo L, Pais de Barros JP, Wetzel A, Tarris G, Pallot G, Martin L, Valmary-Degano S, Deckert V, Lagrost L, Daguindau E, Saas P

Am J Transplant. 2022 Jan 17;:

Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke.

Leskelä J, Toppila I, Härma MA, Palviainen T, Salminen A, Sandholm N, Pietiäinen M, Kopra E, Pais de Barros JP, ,Lassenius MI, Kumar A, Harjutsalo V, Roslund K, Forsblom C, Loukola A, Havulinna AS, Lagrost L, Salomaa V, Groop PH, Perola M, Kaprio J, Lehto M, Pussinen PJ

J Am Heart Assoc. 2021 Oct 20;:e022482

RESVEGA, a Nutraceutical Omega-3/Resveratrol Supplementation, Reduces Angiogenesis in a Preclinical Mouse Model of Choroidal Neovascularization.

Courtaut F, Aires V, Acar N, Bretillon L, Guerrera IC, Chhuon C, Pais de Barros JP, Olmiere C, Delmas D

Int J Mol Sci. 2021 Oct 13;22(20):

Muricholic Acids Promote Resistance to Hypercholesterolemia in Cholesterol-Fed Mice.

Gaillard D, Masson D, Garo E, Souidi M, Pais de Barros JP, Schoonjans K, Grober J, Besnard P, Thomas C

Int J Mol Sci. 2021 Jul 2;22(13):

VEGF-R2/Caveolin-1 Pathway of Undifferentiated ARPE-19 Retina Cells: A Potential Target as Anti-VEGF-A Therapy in Wet AMD by Resvega, an Omega-3/Polyphenol Combination.

Courtaut F, Scagliarini A, Aires V, Cornebise C, Pais de Barros JP, Olmiere C, Delmas D

Int J Mol Sci. 2021 Jun 19;22(12):

Mediterranean diet and prudent diet are both associated with low circulating esterified 3-hydroxy fatty acids, a proxy of LPS burden, among older adults.

André P, Pais de Barros JP, Mj Merle B, Samieri C, Helmer C, Delcourt C, Féart C

Am J Clin Nutr. 2021 May 24;:

The Tryptophan/Kynurenine Pathway: A Novel Cross-Talk between Nutritional Obesity, Bariatric Surgery and Taste of Fat.

Bernard A, Le May C, Dastugue A, Ayer A, Blanchard C, Martin JC, Pais de Barros JP, Delaby P, Le Bourgot C, Ledoux S, Besnard P

Nutrients. 2021 Apr 19;13(4):

Attenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: potential for the prevention of age-related diseases.

Nury T, Yammine A, Ghzaiel I, Sassi K, Zarrouk A, Brahmi F, Samadi M, Rup-Jacques S, Vervandier-Fasseur D, Pais de Barros JP, Bergas V, Ghosh S, Majeed M, Pande A, Atanasov A, Hammami S, Hammami M, Mackrill J, Nasser B, Andreoletti P, Cherkaoui-Malki M, Vejux A, Lizard G

Ageing Res Rev. 2021 Mar 24;:101324

HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias.

Mshaik R, Simonet J, Georgievski A, Jamal L, Bechoua S, Ballerini P, Bellaye PS, Mlamla Z, Pais de Barros JP, Geissler A, Francin PJ, Girodon F, Garrido C, Quéré R

Blood Cancer J. 2021 Mar 18;11(3):61

Liraglutide Increases the Catabolism of Apolipoprotein B100-Containing Lipoproteins in Patients With Type 2 Diabetes and Reduces Proprotein Convertase Subtilisin/Kexin Type 9 Expression.

Vergès B, Duvillard L, Pais de Barros JP, Bouillet B, Baillot-Rudoni S, Rouland A, Petit JM, Degrace P, Demizieux L

Diabetes Care. 2021 Feb 2;:

Endocannabinoids Produced by White Adipose Tissue Modulate Lipolysis in Lean but Not in Obese Rodent and Human.

Buch C, Muller T, Leemput J, Passilly-Degrace P, Ortega-Deballon P, Pais de Barros JP, Vergès B, Jourdan T, Demizieux L, Degrace P

Front Endocrinol (Lausanne). 2021 ;12:716431

Endotoxin Mass Concentration in Plasma Is Associated With Mortality in a Multicentric Cohort of Peritonitis-Induced Shock.

Payen D, Dupuis C, Deckert V, Pais de Barros JP, Rérole AL, Lukaszewicz AC, Coudroy R, Robert R, Lagrost L

Front Med (Lausanne). 2021 ;8:749405

Intra-Abdominal Lipopolysaccharide Clearance and Inactivation in Peritonitis: Key Roles for Lipoproteins and the Phospholipid Transfer Protein.

Nguyen M, Pallot G, Jalil A, Tavernier A, Dusuel A, Le Guern N, Lagrost L, Pais de Barros JP, Choubley H, Bergas V, Guinot PG, Masson D, Bouhemad B, Gautier T

Front Immunol. 2021 ;12:622935

New Insights on End-Stage Renal Disease and Healthy Individual Gut Bacterial Translocation: Different Carbon Composition of Lipopolysaccharides and Different Impact on Monocyte Inflammatory Response.

Adda-Rezig H, Carron C, Pais de Barros JP, Choubley H, Charron É, Rérole AL, Laheurte C, Louvat P, Gaiffe É, Simula-Faivre D, Deckert V, Lagrost L, Saas P, Ducloux D, Bamoulid J

Front Immunol. 2021 ;12:658404

Deletion of lysophosphatidylcholine acyltransferase 3 in myeloid cells worsens hepatic steatosis after a high-fat diet.

Bourgeois T, Jalil A, Thomas C, Magnani C, Le Guern N, Gautier T, Pais de Barros JP, Bergas V, Choubley H, Mazzeo L, Menegaut L, Josiane Lebrun L, Van Dongen K, Xolin M, Jourdan T, Buch C, Labbé J, Saas P, Lagrost L, Masson D, Grober J

J Lipid Res. 2020 Dec 17;62:100013

Human cholesteryl ester transfer protein lacks lipopolysaccharide transfer activity, but worsens inflammation and sepsis outcomes in mice.

Dusuel A, Deckert V, Pais de Barros JP, van Dongen K, Choubley H, Charron É, Le Guern N, Labbé J, Mandard S, Grober J, Lagrost L, Gautier T

J Lipid Res. 2020 Dec 15;62:100011

Deletion of lysophosphatidylcholine acyltransferase3 in myeloid cells worsens hepatic steatosis after a high fat diet.

Bourgeois T, Jalil A, Thomas C, Magnani C, Le Guern N, Gautier T, Pais DE Barros JP, Bergas V, Choubley H, Mazzeo L, Menegaut L, Lebrun L, Van Dongen K, Xolin M, Jourdan T, Buch C, Labbé J, Saas P, Lagrost L, Masson D, Grober J

J Lipid Res. 2020 Dec 11;:

Human CETP lacks lipopolysaccharide transfer activity, but worsens inflammation and sepsis outcomes in mice.

Dusuel A, Deckert V, Pais DE Barros JP, Van Dongen K, Choubley H, Charron E, Le Guern N, Labbé J, Mandard S, Grober J, Lagrost L, Gautier T

J Lipid Res. 2020 Dec 9;:

LDL apheresis as an alternate method for plasma LPS purification in healthy volunteers and dyslipidemic and septic patients.

Dargent A, Pais de Barros JP, Saheb S, Bittar R, Le Goff W, Carrié A, Gautier T, Fournel I, Rerole AL, Choubley H, Masson D, Lagrost L, Quenot JP

J Lipid Res. 2020 Dec;61(12):1776-1783

LDL apheresis as an alternate method for plasma LPS purification in healthy volunteers and dyslipidemic and septic patients.

Dargent A, Pais de Barros JP, Saheb S, Bittar R, Le Goff W, Carrié A, Gautier T, Fournel I, Rerole AL, Choubley H, Masson D, Lagrost L, Quenot JP

J Lipid Res. 2020 Dec;61(12):1776-1783

Specific shifts in the endocannabinoid system in hibernating brown bears.

Boyer C, Cussonneau L, Brun C, Deval C, Pais de Barros JP, Chanon S, Bernoud-Hubac N, Daira P, Evans AL, Arnemo JM, Swenson JE, Gauquelin-Koch G, Simon C, Blanc S, Combaret L, Bertile F, Lefai E

Front Zool. 2020 Nov 23;17(1):35

CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS.

Blot M, Jacquier M, Aho Glele LS, Beltramo G, Nguyen M, Bonniaud P, Prin S, Andreu P, Bouhemad B, Bour JB, Binquet C, Piroth L, Pais de Barros JP, Masson D, Quenot JP, Charles PE,

Crit Care. 2020 11 2;24(1):632

LDL-apheresis as an alternate method for plasma LPS purification in healthy volunteers, dyslipidemic and septic patients.

Dargent A, Pais DE Barros JP, Saheb S, Bittar R, Le Goff W, Carrié A, Gautier T, Fournel I, Rérole AL, Choubley H, Masson D, Lagrost L, Quenot JP

J Lipid Res. 2020 Oct 9;:

Fatty acid composition of the erythrocyte membrane and risk of hepatocellular carcinoma in cirrhotic patients.

Mouillot T, Rizk M, Pais de Barros JP, Gilloteau A, Busson A, Bernard-Chabert B, Thiefin G, Barraud H, Bronowicki JP, Richou C, Di Martino V, Doffoel M, Minello A, Latournerie M, Jouve JL, Brondel L, Brindisi MC, Petit JM, Hillon P, Cottet V,

Aliment. Pharmacol. Ther.. 2020 Aug 11;:

Glucocorticoids impair HDL-mediated cholesterol efflux besides increased HDL cholesterol concentration - a proof of concept.

Bouillet B, Gautier T, Denimal D, Samson M, Masson D, Pais de Barros JP, Maquart G, Xolin M, Grosfeld A, Dalle H, Vergès B, Moldes M, Fève B

Eur. J. Endocrinol.. 2020 Jun 1;:

Interplay between Liver X Receptor and Hypoxia Inducible Factor 1α Potentiates Interleukin-1β Production in Human Macrophages.

Ménégaut L, Thomas C, Jalil A, Julla JB, Magnani C, Ceroi A, Basmaciyan L, Dumont A, Le Goff W, Mathew MJ, Rébé C, Dérangère V, Laubriet A, Crespy V, Pais de Barros JP, Steinmetz E, Venteclef N, Saas P, Lagrost L, Masson D

Cell Rep. 2020 May 19;31(7):107665

Nanosphere-shaped ammonio methacrylate copolymers: converting a pharmaceutical inactive ingredient to efficient therapeutics for experimental colitis.

Moulari B, Shetab Boushehri MA, Pais de Barros JP, Faber T, Béduneau A, Lagrost L, Pellequer Y, Lamprecht A

Nanoscale. 2020 Apr 21;:

IL-33/ST2 pathway regulates neutrophil migration and predicts outcome in patients with severe alcoholic hepatitis.

Artru F, Saleh MB, Maggiotto F, Lassailly G, Ningarhari M, Demaret J, Ntandja-Wandji LC, Pais de Barros JP, Labreuche J, Drumez E, Helou DG, Dharancy S, Gantier E, Périanin A, Chollet-Martin S, Bataller R, Mathurin P, Dubuquoy L, Louvet A

J. Hepatol.. 2020 Jan 14;:

Improved quantification of plasma lipopolysaccharide (LPS) burden in sepsis using 3-hydroxy myristate (3HM): a cohort study.

Dargent A, Pais De Barros JP, Ksiazek E, Fournel I, Dusuel A, Rerole AL, Choubley H, Masson D, Lagrost L, Quenot JP

Intensive Care Med. 2019 Aug 26;:

Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrial alterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol.

Sghaier R, Nury T, Leoni V, Caccia C, Pais De Barros JP, Cherif A, Vejux A, Moreau T, Lime K, Samadi M, Mackrill JJ, Masmoudi AS, Lizard G, Zarrouk A

J. Steroid Biochem. Mol. Biol.. 2019 Jul 22;:105432

Healthy adiposity and extended lifespan in obese mice fed a diet supplemented with a polyphenol-rich plant extract.

Aires V, Labbé J, Deckert V, Pais de Barros JP, Boidot R, Haumont M, Maquart G, Le Guern N, Masson D, Prost-Camus E, Prost M, Lagrost L

Sci Rep. 2019 Jun 24;9(1):9134

Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1β secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment.

Dumont A, de Rosny C, Kieu TL, Perrey S, Berger H, Fluckiger A, Muller T, Pais de Barros JP, Pichon L, Hichami A, Thomas C, Rébé C, Ghiringhelli F, Rialland M

Cell Death Dis. 2019 Jun 19;10(7):485

Phospholipid profiles and hepatocellular carcinoma risk and prognosis in cirrhotic patients.

Cotte AK, Cottet V, Aires V, Mouillot T, Rizk M, Vinault S, Binquet C, de Barros JP, Hillon P, Delmas D

Oncotarget. 2019 Mar 15;10(22):2161-2172

High-fat diet disturbs lipid raft/TGF-β signaling-mediated maintenance of hematopoietic stem cells in mouse bone marrow.

Hermetet F, Buffière A, Aznague A, Pais de Barros JP, Bastie JN, Delva L, Quéré R

Nat Commun. 2019 Jan 31;10(1):523

Age-Related Changes in the Gut Microbiota Modify Brain Lipid Composition.

Albouery M, Buteau B, Grégoire S, Cherbuy C, Pais de Barros JP, Martine L, Chain F, Cabaret S, Berdeaux O, Bron AM, Acar N, Langella P, Bringer MA

Front Cell Infect Microbiol. 2019 ;9:444

End-Stage Renal Disease-Associated Gut Bacterial Translocation: Evolution and Impact on Chronic Inflammation and Acute Rejection After Renal Transplantation.

Carron C, Pais de Barros JP, Gaiffe E, Deckert V, Adda-Rezig H, Roubiou C, Laheurte C, Masson D, Simula-Faivre D, Louvat P, Moulin B, Frimat L, Rieu P, Mousson C, Durrbach A, Heng AE, Saas P, Ducloux D, Lagrost L, Bamoulid J

Front Immunol. 2019 ;10:1630

Polysaccharide Chain Length of Lipopolysaccharides From Minnesota Is a Determinant of Aggregate Stability, Plasma Residence Time and Proinflammatory Propensity .

Sali W, Patoli D, Pais de Barros JP, Labbé J, Deckert V, Duhéron V, Le Guern N, Blache D, Chaumont D, Lesniewska E, Gasquet B, Paul C, Moreau M, Denat F, Masson D, Lagrost L, Gautier T

Front Microbiol. 2019 ;10:1774

Liraglutide Reduces Postprandial Hyperlipidemia by Increasing ApoB48 (Apolipoprotein B48) Catabolism and by Reducing ApoB48 Production in Patients With Type 2 Diabetes Mellitus.

Vergès B, Duvillard L, Pais de Barros JP, Bouillet B, Baillot-Rudoni S, Rouland A, Sberna AL, Petit JM, Degrace P, Demizieux L

Arterioscler. Thromb. Vasc. Biol.. 2018 Jul 19;:

Author Correction: Obese Subjects With Specific Gustatory Papillae Microbiota and Salivary Cues Display an Impairment to Sense Lipids.

Besnard P, Christensen JE, Brignot H, Bernard A, Passilly-Degrace P, Nicklaus S, Pais de Barros JP, Collet X, Lelouvier B, Servant F, Blasco-Baque V, Verges B, Lagrost L, Feron G, Burcelin R

Sci Rep. 2018 Jun 22;8(1):9773

Circulating levels of 3-hydroxymyristate, a direct quantification of endotoxemia in non-infected cirrhotic patients.

Weil D, Pais de Barros JP, Mourey G, Laheurte C, Cypriani B, Badet N, Delabrousse E, Grandclément E, Di Martino V, Saas P, Lagrost L, Thévenot T

Liver Int.. 2018 Jun 22;:

LPCAT3 deficiency in hematopoietic cells alters cholesterol and phospholipid homeostasis and promotes atherosclerosis.

Thomas C, Jalil A, Magnani C, Ishibashi M, Queré R, Bourgeois T, Bergas V, Ménégaut L, Patoli D, Le Guern N, Labbé J, Gautier T, de Barros JPP, Lagrost L, Masson D

Atherosclerosis. 2018 May 18;:

Microbial ecology perturbation in human IgA deficiency.

Fadlallah J, El Kafsi H, Sterlin D, Juste C, Parizot C, Dorgham K, Autaa G, Gouas D, Almeida M, Lepage P, Pons N, Le Chatelier E, Levenez F, Kennedy S, Galleron N, de Barros JP, Malphettes M, Galicier L, Boutboul D, Mathian A, Miyara M, Oksenhendler E, Amoura Z, Doré J, Fieschi C, Ehrlich SD, Larsen M, Gorochov G

Sci Transl Med. 2018 05 2;10(439):

Obese Subjects With Specific Gustatory Papillae Microbiota and Salivary Cues Display an Impairment to Sense Lipids.

Besnard P, Christensen JE, Brignot H, Bernard A, Passilly-Degrace P, Nicklaus S, Pais de Barros JP, Collet X, Lelouvier B, Servant F, Blasco V, Verges B, Lagrost L, Feron G, Burcelin R

Sci Rep. 2018 Apr 30;8(1):6742

Cholesterol trafficking and raft-like membrane domain composition mediate scavenger receptor class B type 1-dependent lipid sensing in intestinal epithelial cells.

Morel E, Ghezzal S, Lucchi G, Truntzer C, Pais de Barros JP, Simon-Plas F, Demignot S, Mineo C, Shaul PW, Leturque A, Rousset M, Carrière V

Biochim. Biophys. Acta. 2018 02;1863(2):199-211

Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance.

Cotte AK, Aires V, Fredon M, Limagne E, Derangère V, Thibaudin M, Humblin E, Scagliarini A, de Barros JP, Hillon P, Ghiringhelli F, Delmas D

Nat Commun. 2018 01 22;9(1):322

PhosphoLipid transfer protein (PLTP) exerts a direct pro-inflammatory effect on rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) independently of its lipid transfer activity.

Audo R, Deckert V, Daien CI, Che H, Elhmioui J, Lemaire S, Pais de Barros JP, Desrumaux C, Combe B, Hahne M, Lagrost L, Morel J

PLoS ONE. 2018 ;13(3):e0193815

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion.

Lebrun LJ, Lenaerts K, Kiers D, Pais de Barros JP, Le Guern N, Plesnik J, Thomas C, Bourgeois T, Dejong CHC, Kox M, Hundscheid IHR, Khan NA, Mandard S, Deckert V, Pickkers P, Drucker DJ, Lagrost L, Grober J

Cell Rep. 2017 Oct 31;21(5):1160-1168

Sleeve Gastrectomy Alters Intestinal Permeability in Diet-Induced Obese Mice.

Blanchard C, Moreau F, Chevalier J, Ayer A, Garcon D, Arnaud L, Pais de Barros JP, Gautier T, Neunlist M, Cariou B, Le May C

Obes Surg. 2017 10;27(10):2590-2598

Impairment of the Ability of HDL From Patients With Metabolic Syndrome but Without Diabetes Mellitus to Activate eNOS: Correction by S1P Enrichment.

Denimal D, Monier S, Brindisi MC, Petit JM, Bouillet B, Nguyen A, Demizieux L, Simoneau I, Pais de Barros JP, Vergès B, Duvillard L

Arterioscler. Thromb. Vasc. Biol.. 2017 Mar;:

Overactivation of the endocannabinoid system alters the anti-lipolytic action of insulin in mouse adipose tissue.

Muller T, Demizieux L, Troy-Fioramonti S, Gresti J, Pais de Barros JP, Berger H, Vergès B, Degrace P

Am. J. Physiol. Endocrinol. Metab.. 2017 Mar;:ajpendo.00374.2016

Is It Time to Reconsider the Lipopolysaccharide Paradigm in Acute Graft-Versus-Host Disease?

Daguindau E, Gautier T, Chagué C, Pais de Barros JP, Deckert V, Lagrost L, Saas P

Front Immunol. 2017 ;8:952

Targeted Lipidomic Analysis of Myoblasts by GC-MS and LC-MS/MS.

Blondelle J, Pais de Barros JP, Pilot-Storck F, Tiret L

Methods Mol. Biol.. 2017 ;1668:39-60

Plasma phospholipid transfer protein (PLTP) modulates adaptive immune functions through alternation of T helper cell polarization.

Desrumaux C, Lemaire-Ewing S, Ogier N, Yessoufou A, Hammann A, Sequeira-Le Grand A, Deckert V, Pais de Barros JP, Le Guern N, Guy J, Khan NA, Lagrost L

Cell. Mol. Immunol.. 2016 Nov;13(6):795-804

CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts.

Saint-Paul L, Nguyen CH, Buffière A, Pais de Barros JP, Hammann A, Landras-Guetta C, Filomenko R, Chrétien ML, Johnson P, Bastie JN, Delva L, Quéré R

Oncotarget. 2016 10;7(40):64785-64797

Specific enrichment of 2-arachidonoyl-lysophosphatidylcholine in carotid atheroma plaque from type 2 diabetic patients.

Ménégaut L, Masson D, Abello N, Denimal D, Truntzer C, Ducoroy P, Lagrost L, Pais de Barros JP, Athias A, Petit JM, Martin L, Steinmetz E, Kretz B

Atherosclerosis. 2016 Aug;251:339-47

Short Term Palmitate Supply Impairs Intestinal Insulin Signaling via Ceramide Production.

Tran TT, Postal BG, Demignot S, Ribeiro A, Osinski C, Pais de Barros JP, Blachnio-Zabielska A, Leturque A, Rousset M, Ferré P, Hajduch E, Carrière V

J. Biol. Chem.. 2016 07 29;291(31):16328-38

Reduced cardiolipin content decreases respiratory chain capacities and increases ATP synthesis yield in the human HepaRG cells.

Peyta L, Jarnouen K, Pinault M, Guimaraes C, Pais de Barros JP, Chevalier S, Dumas JF, Maillot F, Hatch GM, Loyer P, Servais S

Biochim. Biophys. Acta. 2016 Apr;1857(4):443-53

Major changes in the sphingophospholipidome of HDL in non-diabetic patients with metabolic syndrome.

Denimal D, Nguyen A, Pais de Barros JP, Bouillet B, Petit JM, Vergès B, Duvillard L

Atherosclerosis. 2016 Mar;246:106-14

Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation.

Sun X, Haas ME, Miao J, Mehta A, Graham MJ, Crooke RM, Pais de Barros JP, Wang JG, Aikawa M, Masson D, Biddinger SB

J. Biol. Chem.. 2016 Jan 15;291(3):1115-22

Oxidation-induced loss of the ability of HDL to counteract the inhibitory effect of oxidized LDL on vasorelaxation.

Perségol L, Brindisi MC, Rageot D, Pais de Barros JP, Monier S, Vergès B, Duvillard L

Heart Vessels. 2015 Nov;30(6):845-9

Regulation of hepatic cardiolipin metabolism by TNFα: Implication in cancer cachexia.

Peyta L, Jarnouen K, Pinault M, Coulouarn C, Guimaraes C, Goupille C, de Barros JP, Chevalier S, Dumas JF, Maillot F, Hatch GM, Loyer P, Servais S

Biochim Biophys Acta. 2015 11;1851(11):1490-500

Quantitative lipopolysaccharide analysis using HPLC/MS/MS and its combination with the limulus amebocyte lysate assay.

Pais de Barros JP, Gautier T, Sali W, Adrie C, Choubley H, Charron E, Lalande C, Le Guern N, Deckert V, Monchi M, Quenot JP, Lagrost L

J. Lipid Res.. 2015 Jul;56(7):1363-9

Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrial function in liver of a high-fat, high-sucrose diet mice model.

Vial G, Chauvin MA, Bendridi N, Durand A, Meugnier E, Madec AM, Bernoud-Hubac N, Pais de Barros JP, Fontaine É, Acquaviva C, Hallakou-Bozec S, Bolze S, Vidal H, Rieusset J

Diabetes. 2015 Jun;64(6):2254-64

Tif1gamma regulates the TGF-beta1 receptor and promotes physiological aging of hematopoietic stem cells.

Quere R, Saint-Paul L, Carmignac V, Martin RZ, Chretien ML, Largeot A, Hammann A, Pais de Barros JP, Bastie JN, Delva L

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10592-7

Dr PAIS DE BARROS Jean-Paul

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