Mme LAHEURTE Caroline

Fiche personne

Coordonnées

EFS BFC
8 rue du Dr Giroud

25000 BESANCON

03 81 61 56 15

Territoire

Franche-Comté

Statut

Ingénieur/Technicien

Affiliation

Inserm UMR 1098 "Interaction Hôte-Greffon-Tumeur, Ingénierie Cellulaire et Génique" (Inserm UMR1098 RIGHT)

Équipes/plateformes

Plateforme Biomonitoring

Publications

First-line durvalumab and tremelimumab with chemotherapy in RAS-mutated metastatic colorectal cancer: a phase 1b/2 trial.

Thibaudin M, Fumet JD, Chibaudel B, Bennouna J, Borg C, Martin-Babau J, Cohen R, Fonck M, Taieb J, Limagne E, Blanc J, Ballot E, Hampe L, Bon M, Daumoine S, Peroz M, Mananet H, Derangère V, Boidot R, Michaud HA, Laheurte C, Adotevi O, Bertaut A, Truntzer C, Ghiringhelli F

Nat Med. 2023 08 10;:

Pre-transplant immune profile defined by principal component analysis predicts acute rejection after kidney transplantation.

Gaiffe E, Colladant M, Desmaret M, Bamoulid J, Leroux F, Laheurte C, Brouard S, Giral M, Saas P, Courivaud C, Degauque N, Ducloux D

Front Immunol. 2023 07 11;14:1192440

Response to Chemoimmunotherapy Is Associated With Expansion of Systemic Antitumor CD4+ Th1 Response in Metastatic Non-Small Cell Lung Cancer.

Wespiser M, Marguier A, Lecoester B, Richard T, Boullerot L, Malfroy M, Kumar A, Laheurte C, Adotévi O

J Immunother. 2023 02 20;:

Safety, Immunogenicity, and 1-Year Efficacy of Universal Cancer Peptide-Based Vaccine in Patients With Refractory Advanced Non-Small-Cell Lung Cancer: A Phase Ib/Phase IIa De-Escalation Study.

Adotévi O, Vernerey D, Jacoulet P, Meurisse A, Laheurte C, Almotlak H, Jacquin M, Kaulek V, Boullerot L, Malfroy M, Orillard E, Eberst G, Lagrange A, Favier L, Gainet-Brun M, Doucet L, Teixeira L, Ghrieb Z, Clairet AL, Guillaume Y, Kroemer M, Hocquet D, Moltenis M, Limat S, Quoix E, Mascaux C, Debieuvre D, Fagnoni-Legat C, Borg C, Westeel V

J Clin Oncol. 2022 09 7;:JCO2200096

Interplay between plasmacytoid dendritic cells and tumor-specific T cells in peripheral blood influences long-term survival in non-small cell lung carcinoma.

Laheurte C, Seffar E, Gravelin E, Lecuelle J, Renaudin A, Boullerot L, Malfroy M, Marguier A, Lecoester B, Gaugler B, Saas P, Truntzer C, Ghiringhelli F, Adotevi O

Cancer Immunol Immunother. 2022 08 21;:

TIE-2 Signaling Activation by Angiopoietin 2 On Myeloid-Derived Suppressor Cells Promotes Melanoma-Specific T-cell Inhibition.

Marguier A, Laheurte C, Lecoester B, Malfroy M, Boullerot L, Renaudin A, Seffar E, Kumar A, Nardin C, Aubin F, Adotevi O

Front Immunol. 2022 07 22;13:932298

Prognostic value of CD4+ T lymphopenia in non-small cell lung Cancer.

Eberst G, Vernerey D, Laheurte C, Meurisse A, Kaulek V, Cuche L, Jacoulet P, Almotlak H, Lahourcade J, Gainet-Brun M, Fabre E, Le Pimpec-Barthes F, Adotevi O, Westeel V

BMC Cancer. 2022 05 11;22(1):529

Weak immunogenicity of SARS-CoV-2 vaccine in patients with hematologic malignancies.

Malard F, Gaugler B, Gozlan J, Bouquet L, Fofana D, Siblany L, Eshagh D, Adotevi O, Laheurte C, Ricard L, Dulery R, Stocker N, van de Wyngaert Z, Genthon A, Banet A, Memoli M, Ikhlef S, Sestilli S, Vekhof A, Brissot E, Marjanovic Z, Chantran Y, Cuervo N, Ballot E, Morand-Joubert L, Mohty M

Blood Cancer J. 2021 08 10;11(8):142

Naturally occurring Telomerase-specific CD4 T cell Immunity in Melanoma.

Nardin C, Laheurte C, Puzenat E, Boullerot L, Ramseyer M, Marguier A, Jacquin M, Godet Y, Aubin F, Adotevi O

J Invest Dermatol. 2021 Aug 2;:

Inflammatory and immunological profile in COPD secondary to organic dust exposure.

Keddache S, Laheurte C, Boullerot L, Laurent L, Dalphin JC, Adotevi O, Soumagne T

Clin Immunol. 2021 Jul 16;:108798

Small Annexin V-Positive Platelet-Derived Microvesicles Affect Prognosis in Cirrhosis: A Longitudinal Study.

Weil D, Di Martino V, Mourey G, Biichle S, Renaudin A, Laheurte C, Cypriani B, Delabrousse E, Grandclément E, Thévenot T, Saas P,

Clin Transl Gastroenterol. 2021 Apr 28;12(5):e00333

New Insights on End-Stage Renal Disease and Healthy Individual Gut Bacterial Translocation: Different Carbon Composition of Lipopolysaccharides and Different Impact on Monocyte Inflammatory Response.

Adda-Rezig H, Carron C, Pais de Barros JP, Choubley H, Charron É, Rérole AL, Laheurte C, Louvat P, Gaiffe É, Simula-Faivre D, Deckert V, Lagrost L, Saas P, Ducloux D, Bamoulid J

Front Immunol. 2021 ;12:658404

Visceral adiposity in patients with psoriatic arthritis and psoriasis alone and its relationship with metabolic and cardiovascular risk.

Toussirot E, Aubin F, Desmarets M, Wendling D, Augé B, Gillard J, Messica O, Guillot X, Laheurte C, Monnet E, Dumoulin G

Rheumatology (Oxford). 2020 Nov 24;:

Processing methods and storage duration impact extracellular vesicle counts in red blood cell units.

Gamonet C, Desmarets M, Mourey G, Biichle S, Aupet S, Laheurte C, François A, Resch E, Bigey F, Binda D, Bardiaux L, Naegelen C, Marpaux N, Delettre FA, Saas P, Morel P, Tiberghien P, Lacroix J, Capellier G, Vidal C, Garnache-Ottou F

Blood Adv. 2020 Nov 10;4(21):5527-5539

PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy.

Simon S, Voillet V, Vignard V, Wu Z, Dabrowski C, Jouand N, Beauvais T, Khammari A, Braudeau C, Josien R, Adotevi O, Laheurte C, Aubin F, Nardin C, Rulli S, Gottardo R, Ramchurren N, Cheever M, Fling SP, Church CD, Nghiem P, Dreno B, Riddell SR, Labarriere N

J Immunother Cancer. 2020 Nov;8(2):

Pre-transplant Thymic Function Predicts Is Associated With Patient Death After Kidney Transplantation.

Courivaud C, Bamoulid J, Crepin T, Gaiffe E, Laheurte C, Saas P, Ducloux D

Front Immunol. 2020 ;11:1653

Immunoregulation and Clinical Implications of ANGPT2/TIE2+ M-MDSC Signature in Non-Small Cell Lung Cancer.

Lauret Marie Joseph E, Laheurte C, Jary M, Boullerot L, Asgarov K, Gravelin E, Bouard A, Rangan L, Dosset M, Borg C, Adotévi O

Cancer Immunol Res. 2019 Dec 23;:

[Premature immune senescence and chronic kidney disease: Update and perspectives].

Crépin T, Legendre M, Courivaud C, Vauchy C, Laheurte C, Rebibou JM, Saas P, Ducloux D, Bamoulid J

Nephrol. Ther.. 2019 Dec 14;:

Metronomic cyclophosphamide induces regulatory T cells depletion and PSA specific T cells reactivation in patients with biochemical recurrent prostate cancer.

Laheurte C, Thiery-Vuillemin A, Calcagno F, Legros A, Simonin H, Boullerot L, Jacquin M, Nguyen T, Mouillet G, Borg C, Adotévi O

Int. J. Cancer. 2019 Nov 20;:

A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors.

Teixeira L, Medioni J, Garibal J, Adotévi O, Doucet L, Dragon Durey MA, Ghrieb Z, Kiladjian JJ, Brizard M, Laheurte C, Wehbe M, Pliquet E, Escande M, Defrance R, Culine S, Oudard SM, Wain-Hobson S, Doppler V, Huet T, Langlade-Demoyen P

Clin. Cancer Res.. 2019 Sep 26;:

Immune phenotype predicts new onset diabetes after kidney transplantation.

Ducloux D, Courivaud C, Bamoulid J, Crepin T, Gaiffe E, Laheurte C, Vauchy C, Rebibou JM, Saas P, Borot S

Hum. Immunol.. 2019 Sep 9;:

CD4 T cells target colorectal cancer antigens upregulated by oxaliplatin.

Galaine J, Turco C, Vauchy C, Royer B, Mercier-Letondal P, Queiroz L, Loyon R, Mouget V, Boidot R, Laheurte C, Lakkis Z, Jary M, Adotévi O, Borg C, Godet Y

Int. J. Cancer. 2019 Aug 9;:

Distinct prognostic value of circulating anti-telomerase CD4 Th1 immunity and exhausted PD-1/TIM-3 T cells in lung cancer.

Laheurte C, Dosset M, Vernerey D, Boullerot L, Gaugler B, Gravelin E, Kaulek V, Jacquin M, Cuche L, Eberst G, Jacoulet P, Fabre E, Le Pimpec-Barthes F, Tartour E, De Carvalho Bittencourt M, Westeel V, Adotévi O

Br. J. Cancer. 2019 Jul 30;:

Local ice cryotherapy decreases synovial interleukin 6, interleukin 1β, vascular endothelial growth factor, prostaglandin-E2, and nuclear factor kappa B p65 in human knee arthritis: a controlled study.

Guillot X, Tordi N, Laheurte C, Pazart L, Prati C, Saas P, Wendling D

Arthritis Res. Ther.. 2019 Jul 30;21(1):180

Circulating NKp46 Natural Killer cells have a potential regulatory property and predict distinct survival in Non-Small Cell Lung Cancer.

Picard E, Godet Y, Laheurte C, Dosset M, Galaine J, Beziaud L, Loyon R, Boullerot L, Lauret Marie Joseph E, Spehner L, Jacquin M, Eberst G, Gaugler B, Le Pimpec-Barthes F, Fabre E, Westeel V, Caignard A, Borg C, Adotévi O

Oncoimmunology. 2019 ;8(2):e1527498

End-Stage Renal Disease-Associated Gut Bacterial Translocation: Evolution and Impact on Chronic Inflammation and Acute Rejection After Renal Transplantation.

Carron C, Pais de Barros JP, Gaiffe E, Deckert V, Adda-Rezig H, Roubiou C, Laheurte C, Masson D, Simula-Faivre D, Louvat P, Moulin B, Frimat L, Rieu P, Mousson C, Durrbach A, Heng AE, Saas P, Ducloux D, Lagrost L, Bamoulid J

Front Immunol. 2019 ;10:1630

Clinical response and pharmacodynamic assessment of INVAC-1, a DNA plasmid encoding an inactive form of human telomerase reverse transcriptase (hTERT), on immune responses, immune tolerability, tumor burden and circulating tumor DNA (ctDNA) in patients wi

Medioni J, Brizard M, Teixeira LO, Doucet L, Ghrieb Z, Angelergues A, Oudard S, Culine S, Adotevi O, Laheurte C, Dragon-Durey MA, Laurent-Puig P, Kiladjian JJ, Doppler V, Souttou B, Wain-Hobson S, Defrance R, Huet T, Langlade-Demoyen P

Ann. Oncol.. 2018 Oct;29 Suppl 8:viii136

The level of circulating NKp46+ CD56dim CD16+ natural killer cells predicts distinct survival in non-small cell lung cancer.

Picard E, Godet Y, Laheurte C, Boullerot L, Lauret Marie Joseph E, Jacquin M, Kaulek V, Eberst G, Gaugler B, Jacoulet P, Gainet-Brun M, Lahoucarde J, Almotlak H, Le Pimpec-Barthes F, Fabre-Guillevin E, Borg C, Westeel V, Adotevi O

Ann. Oncol.. 2018 Oct;29 Suppl 8:viii485

Uraemia-induced immune senescence and clinical outcomes in chronic kidney disease patients.

Crépin T, Legendre M, Carron C, Vachey C, Courivaud C, Rebibou JM, Ferrand C, Laheurte C, Vauchy C, Gaiffe E, Saas P, Ducloux D, Bamoulid J

Nephrol. Dial. Transplant.. 2018 Sep 6;:

Circulating levels of 3-hydroxymyristate, a direct quantification of endotoxemia in non-infected cirrhotic patients.

Weil D, Pais de Barros JP, Mourey G, Laheurte C, Cypriani B, Badet N, Delabrousse E, Grandclément E, Di Martino V, Saas P, Lagrost L, Thévenot T

Liver Int.. 2018 Jun 22;:

In situ delivery of allogeneic natural killer cell (NK) combined with Cetuximab in liver metastases of gastrointestinal carcinoma: A phase I clinical trial.

Adotevi O, Godet Y, Galaine J, Lakkis Z, Idirene I, Certoux JM, Jary M, Loyon R, Laheurte C, Kim S, Dormoy A, Pouthier F, Barisien C, Fein F, Tiberghien P, Pivot X, Valmary-Degano S, Ferrand C, Morel P, Delabrousse E, Borg C

Oncoimmunology. 2018 ;7(5):e1424673

Increased IL-22- and IL-17A-Producing Mucosal-Associated Invariant T Cells in the Peripheral Blood of Patients With Ankylosing Spondylitis.

Toussirot É, Laheurte C, Gaugler B, Gabriel D, Saas P

Front Immunol. 2018 ;9:1610

Immune reconstitution with two different rabbit polyclonal anti-thymocytes globulins.

Bamoulid J, Crepin T, Gaiffe E, Laheurte C, Moulin B, Frimat L, Rieu P, Mousson C, Durrbach A, Heng AE, Rebibou JM, Saas P, Courivaud C, Ducloux D

Transpl. Immunol.. 2017 Sep;:

Pre-transplant end-stage renal disease-related immune risk profile in kidney transplant recipients predicts post-transplant infections.

Crepin T, Gaiffe E, Courivaud C, Roubiou C, Laheurte C, Moulin B, Frimat L, Rieu P, Mousson C, Durrbach A, Heng AE, Saas P, Bamoulid J, Ducloux D

Transpl Infect Dis. 2016 Jun;18(3):415-22

Immunoprevalence and magnitude of HLA-DP4 versus HLA-DR-restricted spontaneous CD4(+) Th1 responses against telomerase in cancer patients.

Laheurte C, Galaine J, Beziaud L, Dosset M, Kerzerho J, Jacquemard C, Gaugler B, Ferrand C, Dormoy A, Aubin F, Jacoulet P, Westeel V, Borg C, Tartour E, Godet Y, Maillère B, Adotévi O

Oncoimmunology. 2016 May;5(5):e1137416

Pretransplant thymic function predicts acute rejection in antithymocyte globulin-treated renal transplant recipients.

Bamoulid J, Courivaud C, Crepin T, Carron C, Gaiffe E, Roubiou C, Laheurte C, Moulin B, Frimat L, Rieu P, Mousson C, Durrbach A, Heng AE, Rebibou JM, Saas P, Ducloux D

Kidney Int.. 2016 May;89(5):1136-43