Détail - canceropole-wordpress

Synthesis of Differentially Halogenated Lissoclimide Analogues To Probe Ribosome E-Site Binding.

Terrosu S, Nurullina L, Supantanapong N, Pak BS, Nguyen S, Holm M, Wu C, Lin M, Horne D, Sachs MS, Blanchard SC, Yusupov M, Vanderwal CD

ACS Chem Biol. 2025 03 22;:

Crystal structure of the GDP-bound GTPase Era from Staphylococcus aureus.

Klochkova E, Biktimirov A, Islamov D, Belousov A, Validov S, Yusupov M, Usachev K

Biochem Biophys Res Commun. 2024 10 18;735:150852

Cryo-EM structure of the inactive ribosome complex accumulated in chick embryo cells in cold-stress conditions.

Nurullina L, Terrosu S, Myasnikov AG, Jenner LB, Yusupov M

FEBS Lett. 2024 02 23;:

Crystal structure of GTPase YsxC from Staphylococcus aureus.

Biktimirov A, Islamov D, Fatkhullin B, Lazarenko V, Validov S, Yusupov M, Usachev K

Biochem Biophys Res Commun. 2024 01 17;699:149545

mRNA reading frame maintenance during eukaryotic ribosome translocation.

Milicevic N, Jenner L, Myasnikov A, Yusupov M, Yusupova G

Nature. 2023 11 29;:

Structural aspects of RimP binding on small ribosomal subunit from Staphylococcus aureus.

Garaeva N, Fatkhullin B, Murzakhanov F, Gafurov M, Golubev A, Bikmullin A, Glazyrin M, Kieffer B, Jenner L, Klochkov V, Aganov A, Rogachev A, Ivankov O, Validov S, Yusupov M, Usachev K

Structure. 2023 11 14;:

Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.

Zhang J, Lair C, Roubert C, Amaning K, Barrio MB, Benedetti Y, Cui Z, Xing Z, Li X, Franzblau SG, Baurin N, Bordon-Pallier F, Cantalloube C, Sans S, Silve S, Blanc I, Fraisse L, Rak A, Jenner LB, Yusupova G, Yusupov M, Zhang J, Kaneko T, Yang TJ, Fotouhi N, Nuermberger E, Tyagi S, Betoudji F, Upton A, Sacchettini JC, Lagrange S

Cell. 2023 02 20;:

Yet Another Similarity between Mitochondrial and Bacterial Ribosomal Small Subunit Biogenesis Obtained by Structural Characterization of RbfA from .

Bikmullin AG, Fatkhullin B, Stetsenko A, Gabdulkhakov A, Garaeva N, Nurullina L, Klochkova E, Golubev A, Khusainov I, Trachtmann N, Blokhin D, Guskov A, Validov S, Usachev K, Yusupov M

Int J Mol Sci. 2023 01 20;24(3):

Y98 Mutation Leads to the Loss of RsfS Anti-Association Activity in .

Fatkhullin B, Golubev A, Garaeva N, Validov S, Gabdulkhakov A, Yusupov M

Int J Mol Sci. 2022 09 18;23(18):

Backbone and side chain NMR assignments for the ribosome maturation factor P (RimP) from Staphylococcus aureus.

Garaeva NS, Bikmullin AG, Fatkhullin BF, Validov SZ, Keiffer B, Yusupov MM, Usachev KS

Biomol NMR Assign. 2022 09 7;:

Is RsfS a Hibernation Factor or a Ribosome Biogenesis Factor?

Fatkhullin BF, Gabdulkhakov AG, Yusupov MM

Biochemistry (Mosc). 2022 06;87(6):500-510

Accuracy mechanism of eukaryotic ribosome translocation.

Djumagulov M, Demeshkina N, Jenner L, Rozov A, Yusupov M, Yusupova G

Nature. 2021 Dec 1;:

Inhibition of the Eukaryotic 80S Ribosome as a Potential Anticancer Therapy: A Structural Perspective.

Pellegrino S, Terrosu S, Yusupova G, Yusupov M

Cancers (Basel). 2021 Aug 31;13(17):

A Path to the Atomic-Resolution Structures of Prokaryotic and Eukaryotic Ribosomes.

Yusupova G, Yusupov M

Biochemistry (Mosc). 2021 Aug;86(8):926-941

Stabilization of Ribosomal RNA of the Small Subunit by Spermidine in .

Belinite M, Khusainov I, Soufari H, Marzi S, Romby P, Yusupov M, Hashem Y

Front Mol Biosci. 2021 ;8:738752

Hibernation as a Stage of Ribosome Functioning.

Usachev KS, Yusupov MM, Validov SZ

Biochemistry (Mosc). 2020 Nov;85(11):1434-1442

Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution.

Golubev A, Fatkhullin B, Khusainov I, Jenner L, Gabdulkhakov A, Validov S, Yusupova G, Yusupov M, Usachev K

FEBS Lett.. 2020 Aug 27;:

Posttranslational modification of Elongation Factor P from Staphylococcus aureus.

Golubev A, Negroni L, Krasnovid F, Validov S, Yusupova G, Yusupov M, Usachev K

FEBS Open Bio. 2020 May 20;:

In vitro Reconstitution of the S. aureus 30S Ribosomal Subunit and RbfA Factor Complex for Structural Studies.

Bikmullin AG, Nurullina LI, Garaeva NS, Klochkova EA, Blokhin DS, Golubev AA, Validov SZ, Khusainov IS, Usachev KS, Yusupov MM

Biochemistry Mosc.. 2020 May;85(5):545-552

Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach.

Khusainov I, Fatkhullin B, Pellegrino S, Bikmullin A, Liu WT, Gabdulkhakov A, Shebel AA, Golubev A, Zeyer D, Trachtmann N, Sprenger GA, Validov S, Usachev K, Yusupova G, Yusupov M

Nat Commun. 2020 Apr 3;11(1):1656

NMR and crystallographic structural studies of the Elongation factor P from Staphylococcus aureus.

Golubev A, Fatkhullin B, Gabdulkhakov A, Bikmullin A, Nurullina L, Garaeva N, Islamov D, Klochkova E, Klochkov V, Aganov A, Khusainov I, Validov S, Yusupova G, Yusupov M, Usachev K

Eur. Biophys. J.. 2020 Mar 9;:

Dimerization of long Hibernation Promoting Factor from Staphylococcus aureus: structural analysis and biochemical characterization.

Usachev KS, Fatkhullin BF, Klochkova EA, Miftakhov AK, Golubev AA, Bikmullin AG, Nurullina LI, Garaeva NS, Islamov DR, Gabdulkhakov AG, Lekontseva NV, Tishchenko SV, Balobanov VA, Sh Khusainov I, Yusupov MM, Validov SZ

J. Struct. Biol.. 2019 Oct 25;:107408

Importance of potassium ions for ribosome structure and function revealed by long-wavelength X-ray diffraction.

Rozov A, Khusainov I, El Omari K, Duman R, Mykhaylyk V, Yusupov M, Westhof E, Wagner A, Yusupova G

Nat Commun. 2019 Jun 7;10(1):2519

Solution structure of the N-terminal domain of the Staphylococcus aureus hibernation promoting factor.

Usachev KS, Validov SZ, Khusainov IS, Varfolomeev AA, Klochkov VV, Aganov AV, Yusupov MM

J. Biomol. NMR. 2019 May;73(5):223-227

The multiple flavors of GoU pairs in RNA.

Westhof E, Yusupov M, Yusupova G

J. Mol. Recognit.. 2019 Apr 29;:e2782

Backbone and side chain NMR assignments for the ribosome binding factor A (RbfA) from Staphylococcus aureus.

Blokhin DS, Bikmullin AG, Nurullina LI, Garaeva NS, Validov SZ, Klochkov VV, Aganov AV, Khusainov IS, Yusupov MM, Usachev KS

Biomol NMR Assign. 2019 04;13(1):27-30

Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome.

Pellegrino S, Meyer M, Könst ZA, Holm M, Voora VK, Kashinskaya D, Zanette C, Mobley DL, Yusupova G, Vanderwal CD, Blanchard SC, Yusupov M

Nucleic Acids Res.. 2019 Feb 13;:

Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism.

Flygaard RK, Boegholm N, Yusupov M, Jenner LB

Nat Commun. 2018 Oct 9;9(1):4179

Backbone and side chain NMR assignments for the ribosome Elongation Factor P (EF-P) from Staphylococcus aureus.

Usachev KS, Golubev AA, Validov SZ, Klochkov VV, Aganov AV, Khusainov IS, Yusupov MM

Biomol NMR Assign. 2018 10;12(2):351-355

Tautomeric G•U pairs within the molecular ribosomal grip and fidelity of decoding in bacteria.

Rozov A, Wolff P, Grosjean H, Yusupov M, Yusupova G, Westhof E

Nucleic Acids Res.. 2018 Aug 21;46(14):7425-7435

Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.

Pellegrino S, Demeshkina N, Mancera-Martinez E, Melnikov S, Simonetti A, Myasnikov A, Yusupov M, Yusupova G, Hashem Y

J. Mol. Biol.. 2018 Aug 17;430(17):2677-2687

NMR assignments of the N-terminal domain of Staphylococcus aureus hibernation promoting factor (SaHPF).

Usachev KS, Ayupov RK, Validov SZ, Khusainov IS, Yusupov MM

Biomol NMR Assign. 2018 04;12(1):85-89

The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth.

Pellegrino S, Meyer M, Zorbas C, Bouchta SA, Saraf K, Pelly SC, Yusupova G, Evidente A, Mathieu V, Kornienko A, Lafontaine DLJ, Yusupov M

Structure. 2018 Mar 6;26(3):416-425.e4

Aminoglycoside interactions and impacts on the eukaryotic ribosome.

Prokhorova I, Altman RB, Djumagulov M, Shrestha JP, Urzhumtsev A, Ferguson A, Chang CT, Yusupov M, Blanchard SC, Yusupova G

Proc. Natl. Acad. Sci. U.S.A.. 2017 12 19;114(51):E10899-E10908

Evidence for rRNA 2'-O-methylation plasticity: Control of intrinsic translational capabilities of human ribosomes.

Erales J, Marchand V, Panthu B, Gillot S, Belin S, Ghayad SE, Garcia M, Laforêts F, Marcel V, Baudin-Baillieu A, Bertin P, Couté Y, Adrait A, Meyer M, Therizols G, Yusupov M, Namy O, Ohlmann T, Motorin Y, Catez F, Diaz JJ

Proc. Natl. Acad. Sci. U.S.A.. 2017 Dec 5;114(49):12934-12939

Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides.

Könst ZA, Szklarski AR, Pellegrino S, Michalak SE, Meyer M, Zanette C, Cencic R, Nam S, Voora VK, Horne DA, Pelletier J, Mobley DL, Yusupova G, Yusupov M, Vanderwal CD

Nat Chem. 2017 Nov;9(11):1140-1149