Détail - canceropole-wordpress

Natural Products to Promote Vascular Health.

Schini-Kerth VB, Diouf I, Muzammel H, Said A, Auger C

Handb Exp Pharmacol. 2024 09 25;:

Polyphenol-rich juice sustains eNOS activation through phosphorylation and expression via redox-sensitive pathways in endothelial cells.

Kim JH, Choi MS, Auger C, Lee KW, Schini-Kerth VB

Food Sci Biotechnol. 2024 09;33(12):2865-2875

Potential of dapagliflozin to prevent vascular remodeling in the rat carotid artery following balloon injury.

Matsushita K, Sato C, Bruckert C, Gong D, Amissi S, Hmadeh S, Fakih W, Remila L, Lessinger JM, Auger C, Jesel L, Ohlmann P, Kauffenstein G, Schini-Kerth VB, Morel O

Atherosclerosis. 2024 05 23;:117595

COVID-19 promotes endothelial dysfunction and thrombogenicity: Role of pro-inflammatory cytokines/SGLT2 pro-oxidant pathway.

Mroueh A, Fakih W, Carmona A, Trimaille A, Matsushita K, Marchandot B, Qureshi AW, Gong DS, Auger C, Sattler L, Reydel A, Hess S, Oulehri W, Vollmer O, Lessinger JM, Meyer N, Pieper MP, Jesel L, Bäck M, Schini-Kerth V, Morel O

J Thromb Haemost. 2023 10 3;:

Empagliflozin prevents angiotensin II-induced hypertension related micro and macrovascular endothelial cell activation and diastolic dysfunction in rats despite persistent hypertension: Role of endothelial SGLT1 and 2.

Bruckert C, Matsushita K, Mroueh A, Amissi S, Auger C, Houngue U, Remila L, Chaker AB, Park SH, Algara-Suarez P, Belcastro E, Jesel L, Ohlmann P, Morel O, Schini-Kerth VB

Vascul Pharmacol. 2022 08 6;:107095

Carissa edulis Vahl (Apocynaceae) extract, a medicinal plant of Benin pharmacopoeia, induces potent endothelium-dependent relaxation of coronary artery rings involving nitric oxide.

Hounguè U, Villette C, Tokoudagba JM, Chaker AB, Remila L, Auger C, Heintz D, Gbaguidi FA, Schini-Kerth VB

Phytomedicine. 2022 08 5;105:154370

Septic shock as a trigger of arterial stress-induced premature senescence: A new pathway involved in the post sepsis long-term cardiovascular complications.

Merdji H, Kassem M, Chomel L, Clere-Jehl R, Helms J, Kurihara K, Chaker AB, Auger C, Schini-Kerth V, Toti F, Meziani F

Vascul Pharmacol. 2021 Sep 27;:106922

Angiotensin II-induced upregulation of SGLT1 and 2 contributes to human microparticle-stimulated endothelial senescence and dysfunction: protective effect of gliflozins.

Park SH, Belcastro E, Hasan H, Matsushita K, Marchandot B, Abbas M, Toti F, Auger C, Jesel L, Ohlmann P, Morel O, Schini-Kerth VB

Cardiovasc Diabetol. 2021 Mar 16;20(1):65

Fluorescent nanocarriers targeting VCAM-1 for early detection of senescent endothelial cells.

Belcastro E, Rehman AU, Remila L, Park SH, Gong DS, Anton N, Auger C, Lefebvre O, Goetz JG, Collot M, Klymchenko AS, Vandamme TF, Schini-Kerth VB

Nanomedicine. 2021 Mar 10;:102379

Biochanin A, the Most Potent of 16 Isoflavones, Induces Relaxation of the Coronary Artery Through the Calcium Channel and cGMP-dependent Pathway.

Migkos T, Pourová J, Vopršalová M, Auger C, Schini-Kerth V, Mladěnka P

Planta Med.. 2020 May 14;:

Red Wine Extract Disrupts Th17 Lymphocyte Differentiation in a Colorectal Cancer Context.

Chalons P, Courtaut F, Limagne E, Chalmin F, Cantos-Villar E, Richard T, Auger C, Chabert P, Schini-Kerth V, Ghiringhelli F, Aires V, Delmas D

Mol Nutr Food Res. 2020 Apr 18;:e1901286

Preventive beneficial effect of an aqueous extract of Phyllanthus amarus Schum. & Thonn. (Euphorbiaceae) on DOCA-salt-induced hypertension, cardiac hypertrophy and dysfunction, and endothelial dysfunction in rats.

Yao NA, Niazi ZR, Najmanová I, Kamagaté M, Said A, Chabert P, Auger C, Die-Kakou H, Schini-Kerth V

J. Cardiovasc. Pharmacol.. 2020 Mar 12;:

Empagliflozin improved systolic blood pressure, endothelial dysfunction and heart remodeling in the metabolic syndrome ZSF1 rat.

Park SH, Farooq MA, Gaertner S, Bruckert C, Qureshi AW, Lee HH, Benrahla D, Pollet B, Stephan D, Ohlmann P, Lessinger JM, Mayoux E, Auger C, Morel O, Schini-Kerth VB

Cardiovasc Diabetol. 2020 Feb 18;19(1):19

Compared Phenolic Compound Contents of 22 Commercial Fruit and Vegetable Juices: Relationship to ex-vivo Vascular Reactivity and Potential in vivo Projection.

Matute A, Tabart J, Cheramy-Bien JP, Pirotte B, Kevers C, Auger C, Schini-Kerth V, Dommes J, Defraigne JO, Pincemail J

Antioxidants (Basel). 2020 Jan 22;9(2):

Intake of omega-3 formulation EPA:DHA 6:1 by old rats for 2 weeks improved endothelium-dependent relaxations and normalized the expression level of ACE/AT1R/NADPH oxidase and the formation of ROS in the mesenteric artery.

Farooq MA, Gaertner S, Amoura L, Niazi ZR, Park SH, Qureshi AW, Oak MH, Toti F, Schini-Kerth VB, Auger C

Biochem. Pharmacol.. 2019 Dec 9;:113749

Ageing enhances the shedding of splenocyte microvesicles with endothelial pro-senescent effect that is prevented by a short-term intake of omega-3 PUFA EPA:DHA 6:1.

Qureshi AW, Altamimy R, El Habhab A, El Itawi H, Farooq MA, Zobairi F, Hasan H, Amoura L, Auger C, Schini-Kerth V, Toti F

Biochem. Pharmacol.. 2019 Dec 4;:113734

Thrombin Induces Angiotensin II-Mediated Senescence in Atrial Endothelial Cells: Impact on Pro-Remodeling Patterns.

Hasan H, Park SH, Auger C, Belcastro E, Matsushita K, Marchandot B, Lee HH, Qureshi AW, Kauffenstein G, Ohlmann P, Schini-Kerth VB, Jesel L, Morel O

J Clin Med. 2019 Oct 1;8(10):

Effects of a High Fat Meal Associated with Water, Juice, or Champagne Consumption on Endothelial Function and Markers of Oxidative Stress and Inflammation in Young, Healthy Subjects.

Rouyer O, Auger C, Charles AL, Talha S, Meyer A, Piquard F, Andres E, Schini-Kerth V, Geny B

J Clin Med. 2019 Jun 15;8(6):

EPA:DHA 6:1 is a superior omega-3 PUFAs formulation attenuating platelets-induced contractile responses in porcine coronary and human internal mammary artery by targeting the serotonin pathway via an increased endothelial formation of nitric oxide.

Zgheel F, Perrier S, Remila L, Houngue U, Mazzucotelli JP, Morel O, Auger C, Schini-Kerth VB

Eur. J. Pharmacol.. 2019 Jun 15;853:41-48

Angiotensin II-induced redox-sensitive SGLT1 and 2 expression promotes high glucose-induced endothelial cell senescence.

Khemais-Benkhiat S, Belcastro E, Idris-Khodja N, Park SH, Amoura L, Abbas M, Auger C, Kessler L, Mayoux E, Toti F, Schini-Kerth VB

J. Cell. Mol. Med.. 2019 Mar 30;:

Urapidil, but not dihydropyridine calcium channel inhibitors, preserves the hypoxic pulmonary vasoconstriction: an experimental study in pig arteries.

Bopp C, Auger C, Mebazaa A, Joshi GP, Schini-Kerth VB, Diemunsch P

Fundam Clin Pharmacol. 2019 Feb 27;:

Tambulin is a major active compound of a methanolic extract of fruits of Zanthoxylum armatum DC causing endothelium-independent relaxations in porcine coronary artery rings via the cyclic AMP and cyclic GMP relaxing pathways.

Mushtaq MN, Ghimire S, Alamgeer,Akhtar MS, Adhikari A, Auger C, Schini-Kerth VB

Phytomedicine. 2019 Feb;53:163-170

Study of Potential Anti-Inflammatory Effects of Red Wine Extract and Resveratrol through a Modulation of Interleukin-1-Beta in Macrophages.

Chalons P, Amor S, Courtaut F, Cantos-Villar E, Richard T, Auger C, Chabert P, Schni-Kerth V, Aires V, Delmas D

Nutrients. 2018 Dec 1;10(12):

An aqueous extract of the Anogeissus leiocarpus bark (AEAL) induces the endothelium-dependent relaxation of porcine coronary artery rings involving predominantly nitric oxide.

Belemnaba L, Ouédraogo S, Nitiéma M, Chataigneau T, Guissou IP, Schini-Kerth VB, Bucher B, Auger C

J Basic Clin Physiol Pharmacol. 2018 Nov 27;29(6):599-608

Mechanisms underlying vasorelaxation induced in the porcine coronary arteries by Thymus linearis, Benth.

Alamgeer,Auger C, Chabert P, Lugnier C, Mushtaq MN, Schini-Kerth VB

J Ethnopharmacol. 2018 Oct 28;225:211-219

Potential mechanisms underlying cardiovascular protection by polyphenols: Role of the endothelium.

Oak MH, Auger C, Belcastro E, Park SH, Lee HH, Schini-Kerth VB

Free Radic. Biol. Med.. 2018 07;122:161-170

Polyphenol-Rich Blackcurrant Juice Prevents Endothelial Dysfunction in the Mesenteric Artery of Cirrhotic Rats with Portal Hypertension: Role of Oxidative Stress and the Angiotensin System.

Rashid S, Idris-Khodja N, Auger C, Kevers C, Pincemail J, Alhosin M, Boehm N, Oswald-Mammosser M, Schini-Kerth VB

J Med Food. 2018 Apr;21(4):390-399

The acute diuretic effect of an ethanolic fraction of Phyllanthus amarus (Euphorbiaceae) in rats involves prostaglandins.

Yao AN, Kamagaté M, Amonkan AK, Chabert P, Kpahé F, Koffi C, Kouamé MN, Auger C, Kati-Coulibaly S, Schini-Kerth V, Die-Kakou H

BMC Complement Altern Med. 2018 Mar 15;18(1):94

Increased risk and severity of unprovoked venous thromboembolism with clustering cardiovascular risk factors for atherosclerosis: Results of the REMOTEV registry.

Gaertner S, Cordeanu EM, Mirea C, Frantz AS, Auger C, Bilbault P, Ohlmann P, Schini-Kerth V, Stephan D

Int. J. Cardiol.. 2018 Feb 1;252:169-174

EPA:DHA 6:1 prevents angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase- and COX-derived oxidative stress.

Niazi ZR, Silva GC, Ribeiro TP, León-González AJ, Kassem M, Mirajkar A, Alvi A, Abbas M, Zgheel F, Schini-Kerth VB, Auger C

Hypertens. Res.. 2017 Dec;40(12):966-975

Senescence of Pancreas in Middle-Aged Rats with Normal Vascular Function.

Kassem M, Niazi ZR, Abbas M, El Habhab A, Kreutter G, Khemais-Benkhiat S, Auger C, Antal MC, Schini-Kerth VB, Toti F, Kessler L

Ann. Transplant.. 2017 Mar 31;22:177-186

Lipid Emulsions Containing Medium Chain Triacylglycerols Blunt Bradykinin-Induced Endothelium-Dependent Relaxation in Porcine Coronary Artery Rings.

Amissi S, Boisramé-Helms J, Burban M, Rashid SK, León-González AJ, Auger C, Toti F, Meziani F, Schini-Kerth VB

Lipids. 2017 03;52(3):235-243

Endothelial Microparticles From Acute Coronary Syndrome Patients Induce Premature Coronary Artery Endothelial Cell Aging and Thrombogenicity: Role of the Ang II/AT1 Receptor/NADPH Oxidase-Mediated Activation of MAPKs and PI3-Kinase Pathways.

Abbas M, Jesel L, Auger C, Amoura L, Messas N, Manin G, Rumig C, León-González AJ, Ribeiro TP, Silva GC, Abou-Merhi R, Hamade E, Hecker M, Georg Y, Chakfe N, Ohlmann P, Schini-Kerth VB, Toti F, Morel O

Circulation. 2017 Jan 17;135(3):280-296

Adenylate Cyclase Type III Is Not a Ubiquitous Marker for All Primary Cilia during Development.

Antal MC, Bénardais K, Samama B, Auger C, Schini-Kerth V, Ghandour S, Boehm N

PLoS ONE. 2017 ;12(1):e0170756

Docosahexaenoic acid, but not eicosapentaenoic acid, improves septic shock-induced arterial dysfunction in rats.

Boivin A, Burban M, Clere-Jehl R, Le Borgne P, Merdji H, Auger C, Schini-Kerth V, Meziani F, Helms J

PLoS ONE. 2017 ;12(12):e0189658

The Redox-sensitive Induction of the Local Angiotensin System Promotes Both Premature and Replicative Endothelial Senescence: Preventive Effect of a Standardized Crataegus Extract.

Khemais-Benkhiat S, Idris-Khodja N, Ribeiro TP, Silva GC, Abbas M, Kheloufi M, Lee JO, Toti F, Auger C, Schini-Kerth VB

J. Gerontol. A Biol. Sci. Med. Sci.. 2016 12;71(12):1581-1590

Endothelium-independent vasorelaxant effect of a Berberis orthobotrys root extract via inhibition of phosphodiesterases in the porcine coronary artery.

Alamgeer,Chabert P, Akhtar MS, Jabeen Q, Delecolle J, Heintz D, Garo E, Hamburger M, Auger C, Lugnier C, Kim HJ, Oak MH, Schini-Kerth VB

Phytomedicine. 2016 Jul;23(8):793-9

Potential of Food and Natural Products to Promote Endothelial and Vascular Health.

Auger C, Said A, Nguyen PN, Chabert P, Idris-Khodja N, Schini-Kerth VB

J. Cardiovasc. Pharmacol.. 2016 Jul;68(1):11-8

The effect of urapidil, an alpha-1 adrenoceptor antagonist and a 5-HT1A agonist, on the vascular tone of the porcine coronary and pulmonary arteries, the rat aorta and the human pulmonary artery.

Bopp C, Auger C, Diemunsch P, Schini-Kerth V

Eur. J. Pharmacol.. 2016 May;779:53-8

Pro-oxidant activity of polyphenols and its implication on cancer chemoprevention and chemotherapy.

Leon-Gonzalez AJ, Auger C, Schini-Kerth VB

Biochem Pharmacol. 2015 Jul 20. pii: S0006-2952(15)00387-1

Great heterogeneity of commercial fruit juices to induce endothelium-dependent relaxations in isolated porcine coronary arteries: role of the phenolic content and composition.

Auger C, Pollet B, Arnold C, Marx C, Schini-Kerth VB

J Med Food. 2015 Jan;18(1):128-36

Tetrahydrocannabinol induces brain mitochondrial respiratory chain dysfunction and increases oxidative stress: a potential mechanism involved in cannabis-related stroke.

Wolff V, Schlagowski AI, Rouyer O, Charles AL, Singh F, Auger C, Schini-Kerth V, Marescaux C, Raul JS, Zoll J, Geny B

Biomed Res Int. 2015 ;2015:323706

Probiotics (VSL#3) prevent endothelial dysfunction in rats with portal hypertension: role of the angiotensin system.

Rashid SK, Khodja NI, Auger C, Alhosin M, Boehm N, Oswald-Mammosser M, Schini-Kerth VB

PLoS One. 2014 May 15;9(5):e97458

Redox-sensitive induction of Src/PI3-kinase/Akt and MAPKs pathways activate eNOS in response to EPA:DHA 6:1.

Zgheel F, Alhosin M, Rashid S, Burban M, Auger C, Schini-Kerth VB

PLoS One. 2014 Aug 18;9(8):e105102

Aronia melanocarpa juice, a rich source of polyphenols, induces endothelium-dependent relaxations in porcine coronary arteries via the redox-sensitive activation of endothelial nitric oxide synthase.

Kim JH, Auger C, Kurita I, Anselm E, Rivoarilala LO, Lee HJ, Lee KW, Schini-Kerth VB

Nitric Oxide. 2013 Nov 30;35:54-64

Role of endothelial cell membrane transport in red wine polyphenols-induced coronary vasorelaxation: involvement of bilitranslocase.

Ziberna L, Kim JH, Auger C, Passamonti S, Schini-Kerth V

Food Funct. 2013 Oct;4(10):1452-6

Hydroxylation of (-)-epigallocatechin-3-O-gallate at 3'', but not 4'', is essential for the PI3-kinase/Akt-dependent phosphorylation of endothelial NO synthase in endothelial cells and relaxation of coronary artery rings.

Kurita I, Kim JH, Auger C, Kinoshita Y, Miyase T, Ito T, Schini-Kerth VB

Food Funct. 2013 Feb;4(2):249-57

Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production.

Charles AL, Meyer A, Dal-Ros S, Auger C, Keller N, Ramamoorthy TG, Zoll J, Metzger D, Schini-Kerth V, Geny B

Exp Physiol. 2013 Feb;98(2):536-45

'ENDOTHELIUM-INDEPENDENT AND ENDOTHELIUM-DEPENDENT VASORELAXATION BY A DICHLOROMETHANE FRACTION FROM ANOGEISSUS LEIOCARPUS (DC) GUILL. ET PERR. (COMBRETACEAE): POSSIBLE INVOLVEMENT OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITION.

Belemnaba L, Ouedraogo S, Auger C, Chataigneau T, Traore A, Guissou IP, Lugnier C, Schini-Kerth VB, Bucher B

Afr J Tradit Complement Alt M. 2013;10(2):173-9.

An ethanolic extract of Lindera obtusiloba stems, YJP-14, improves endothelial dysfunction, metabolic parameters and physical performance in diabetic db/db mice.

Lee JO, Auger C, Park DH, Kang M, Oak MH, Kim KR, Schini-Kerth VB

PLoS One. 2013 Jun 3;8(6):e65227

Endothelium-independent and endothelium-dependent vasorelaxation by a dichloromethane fraction from Anogeissus Leiocarpus (DC) Guill. Et Perr. (Combretaceae): possible involvement of cyclic nucleotide phosphodiesterase inhibition.

Belemnaba L, Ouedraogo S, Auger C, Chataigneau T, Traore A, Guissou IP, Lugnier C, Schini-Kerth VB, Bucher B

Afr J Tradit Complement Altern Med. 2012 Dec 31;10(2):173-9. eCollection 2013.

Molecular mechanisms of the cardiovascular protective effects of polyphenols.

Andriantsitohaina R, Auger C, Chataigneau T, Étienne-Selloum N, Li H, Martínez MC, Schini-Kerth VB, Laher I

Br. J. Nutr.. 2012 Nov 14;108(9):1532-49

Anti-neoplastic agent thymoquinone induces degradation of α and β tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts.

Alhosin M, Ibrahim A, Boukhari A, Sharif T, Gies JP, Auger C, Schini-Kerth VB

Invest New Drugs. 2012 Oct;30(5):1813-9

Crataegus special extract WS((R))1442 prevents aging-related endothelial dysfunction.

Idris-Khodja N, Auger C, Koch E, Schini-Kerth VB

Phytomedicine. 2012 Jun 15;19(8-9):699-706

Red wine polyphenols improve an established aging-related endothelial dysfunction in the mesenteric artery of middle-aged rats: role of oxidative stress.

Dal-Ros S, Bronner C, Auger C, Schini-Kerth VB

Biochem Biophys Res Commun. 2012 Mar 9;419(2):381-7

Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells.

Sharif T, Alhosin M, Auger C, Minker C, Kim JH, Etienne-Selloum N, Bories P, Gronemeyer H, Lobstein A, Bronner C, Fuhrmann G, Schini-Kerth VB

PLoS One. 2012;7(3):e32526

Grape-derived polyphenols improve aging-related endothelial dysfunction in rat mesenteric artery: role of oxidative stress and the angiotensin system.

Idris Khodja N, Chataigneau T, Auger C, Schini-Kerth VB

PLoS One. 2012;7(2):e32039

Natural product extract of Dicksonia sellowiana induces endothelium-dependent relaxations by a redox-sensitive Src- and Akt-dependent activation of eNOS in porcine coronary arteries.

Rattmann YD, Anselm E, Kim JH, Dal-Ros S, Auger C, Miguel OG, Santos AR, Chataigneau T, Schini-Kerth VB

J Vasc Res. 2012;49(4):284-98

Vascular protection by natural product-derived polyphenols: in vitro and in vivo evidence.

Schini-Kerth VB, Etienne-Selloum N, Chataigneau T, Auger C

Planta Med. 2011 Jul;77(11):1161-7

An ethanolic extract of Lindera obtusiloba stems causes NO-mediated endothelium-dependent relaxations in rat aortic rings and prevents angiotensin II-induced hypertension and endothelial dysfunction in rats.

Lee JO, Oak MH, Jung SH, Park DH, Auger C, Kim KR, Lee SW, Schini-Kerth VB

Naunyn Schmiedebergs Arch Pharmacol. 2011 Jun;383(6):635-45

Fruit juice-induced endothelium-dependent relaxations in isolated porcine coronary arteries: evaluation of different fruit juices and purees and optimization of a red fruit juice blend.

Auger C, Kim JH, Trinh S, Chataigneau T, Popken AM, Schini-Kerth VB

Food Funct. 2011 May;2(5):245-50

Selective proapoptotic activity of polyphenols from red wine on teratocarcinoma cell, a model of cancer stem-like cell.

Sharif T, Auger C, Bronner C, Alhosin M, Klein T, Etienne-Selloum N, Schini-Kerth VB, Fuhrmann G

Invest New Drugs. 2011 Apr;29(2):239-47

Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: role of NADPH oxidase.

Dal-Ros S, Zoll J, Lang AL, Auger C, Keller N, Bronner C, Geny B, Schini-Kerth VB

Biochem Biophys Res Commun. 2011 Jan 14;404(2):743-9

Procyanidin-rich fractions from Parkia biglobosa (Mimosaceae) leaves cause redox-sensitive endothelium-dependent relaxation involving NO and EDHF in porcine coronary artery.

Tokoudagba JM, Auger C, Breant L, N'Gom S, Chabert P, Idris-Khodja N, Gbaguidi F, Gbenou J, Moudachirou M, Lobstein A, Schini-Kerth VB

J Ethnopharmacol. 2010 Oct 28;132(1):246-50

Nutritional improvement of the endothelial control of vascular tone by polyphenols: role of NO and EDHF.

Schini-Kerth VB, Auger C, Kim JH, Etienne-Selloum N, Chataigneau T

Pflugers Arch. 2010 May;459(6):853-62

Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1.

Sharif T, Auger C, Alhosin M, Ebel C, Achour M, Etienne-Selloum N, Fuhrmann G, Bronner C, Schini-Kerth VB

Eur J Cancer. 2010 Mar;46(5):983-94

The EGCg-induced redox-sensitive activation of endothelial nitric oxide synthase and relaxation are critically dependent on hydroxyl moieties.

Auger C, Kim JH, Chabert P, Chaabi M, Anselm E, Lanciaux X, Lobstein A, Schini-Kerth VB

Biochem Biophys Res Commun. 2010 Feb 26;393(1):162-7

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