Dr SIMONETTI Angelita

Fiche personne

Coordonnées

IBMC
2 allée Konrad Roentgen
67084 STRASBOURG

03 88 41 70 81

angelita.simonetti@inserm.fr

Territoire

Alsace

Statut

Chercheur

Affiliation

IBMC - Institut de biologie moléculaire et cellulaire (IBMC)

Équipes/plateformes

CNRS UPR 9002 - Equipe "Architecture et réactivité de l'ARN / Structure, dynamique et ciblage des machines biomoléculaires"

Publications

A structural element within the 5'UTR of β-catenin mRNA modulates its translation under hypoxia.

D'Agostino M, Rol-Moreno J, Bec G, Kuhn L, Ennifar E, Simonetti A

Nucleic Acids Res. 2025 04 22;53(8):

Crystal structure of archaeal IF5A-DHS complex reveals insights into the hypusination mechanism.

D'Agostino M, Simonetti A, Motta S, Wolff P, Romagnoli A, Piccinini A, Spinozzi F, Di Marino D, La Teana A, Ennifar E

Structure. 2024 03 27;:

Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts.

Bochler A, Querido JB, Prilepskaja T, Soufari H, Simonetti A, Del Cistia ML, Kuhn L, Ribeiro AR, Valášek LS, Hashem Y

Cell Rep. 2020 Dec 22;33(12):108534

The Halastavi árva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism.

Abaeva IS, Vicens Q, Bochler A, Soufari H, Simonetti A, Pestova TV, Hashem Y, Hellen CUT

Cell Rep. 2020 Dec 8;33(10):108476

Grad-cryo-EM: Tool to Isolate Translation Initiation Complexes from Rabbit Reticulocyte Lysate Suitable for Structural Studies.

Rol-Moreno J, Kuhn L, Marzi S, Simonetti A

Methods Mol. Biol.. 2020 ;2113:329-339

Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.

Pellegrino S, Demeshkina N, Mancera-Martinez E, Melnikov S, Simonetti A, Myasnikov A, Yusupov M, Yusupova G, Hashem Y

J. Mol. Biol.. 2018 Aug 17;430(17):2677-2687

The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein.

Brito Querido J, Mancera-Martínez E, Vicens Q, Bochler A, Chicher J, Simonetti A, Hashem Y

Structure. 2017 12 5;25(12):1785-1794.e3

ABCE1: A special factor that orchestrates translation at the crossroad between recycling and initiation.

Mancera-Martínez E, Brito Querido J, Valasek LS, Simonetti A, Hashem Y

RNA Biol. 2017 10 3;14(10):1279-1285

Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF.

Khusainov I, Vicens Q, Ayupov R, Usachev K, Myasnikov A, Simonetti A, Validov S, Kieffer B, Yusupova G, Yusupov M, Hashem Y

EMBO J.. 2017 Jun;:

Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation.

Martin F, Ménétret JF, Simonetti A, Myasnikov AG, Vicens Q, Prongidi-Fix L, Natchiar SK, Klaholz BP, Eriani G

Nat Commun. 2016 08 24;7:12622

eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.

Simonetti A, Brito Querido J, Myasnikov AG, Mancera-Martinez E, Renaud A, Kuhn L, Hashem Y

Mol. Cell. 2016 07 21;63(2):206-217

Multiple ways to regulate translation initiation in bacteria: Mechanisms, regulatory circuits, dynamics.

Duval M, Simonetti A, Caldelari I, Marzi S

Biochimie. 2015 Jul;114:18-29

Purification of mRNA-programmed translation initiation complexes suitable for mass spectrometry analysis.

Chicher J, Simonetti A, Kuhn L, Schaeffer L, Hammann P, Eriani G, Martin F

Proteomics. 2015 Jul;15(14):2417-25

Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor.

Simonetti A, Marzi S, Billas IM, Tsai A, Fabbretti A, Myasnikov AG, Roblin P, Vaiana AC, Hazemann I, Eiler D, Steitz TA, Puglisi JD, Gualerzi CO, Klaholz BP

Proc. Natl. Acad. Sci. U.S.A.. 2013 Sep 24;110(39):15656-61

A structural view of translation initiation in bacteria.

Simonetti A, Marzi S, Jenner L, Myasnikov A, Romby P, Yusupova G, Klaholz BP, Yusupov M

Cell. Mol. Life Sci.. 2009 Feb;66(3):423-36

Structure of the 30S translation initiation complex.

Simonetti A, Marzi S, Myasnikov AG, Fabbretti A, Yusupov M, Gualerzi CO, Klaholz BP

Nature. 2008 Sep 18;455(7211):416-20

Conformational transition of initiation factor 2 from the GTP- to GDP-bound state visualized on the ribosome.

Myasnikov AG, Marzi S, Simonetti A, Giuliodori AM, Gualerzi CO, Yusupova G, Yusupov M, Klaholz BP

Nat. Struct. Mol. Biol.. 2005 Dec;12(12):1145-9

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