Dr SPECHT Alexandre

Fiche personne

Coordonnées

Faculté de Pharmacie
74 route du Rhin
67401 ILLKIRCH Cedex

03 68 85 41 66

specht@unistra.fr

Territoire

Alsace

Statut

Chercheur

Affiliation

Laboratoire de Conception et Application de Molécules Bioactives - UMR 7199 (LCAMB)

Équipes/plateformes

UMR 7199 - Equipe "Chimie et Neurobiologie Moléculaire (CNM)"

Publications

Robust Photocleavable Linkers for DNA Synthesis: Enabling Visible Light-Triggered Antisense Oligonucleotide Release in 3D DNA Nanocages.

Leung HM, Chan HY, Klimezak M, Liu LS, Karam P, Specht A, Bolze F, Lo PK

Biomacromolecules. 2025 04 24;:

Seeing in the Future - a Perspective on Combining Light with Chemical Biology Approaches to Treat Retinal Pathologies.

Specht A, Klimezak M, Cambridge S

ChemMedChem. 2025 01 8;:e202400827

Optogenetic Manipulation of Transgene Expression in Retinal Neurovasculature.

Brandhorst E, Xu L, Klimezak M, Goegan B, Hong H, Hammes HP, Specht A, Cambridge S

JACS Au. 2024 08 26;4(8):2818-2825

Triplet-Triplet Annihilation Upconversion Based Photolysis: Applications in Photopharmacology.

Klimezak M, Chaud J, Brion A, Bolze F, Frisch B, Heurtault B, Kichler A, Specht A

Adv Healthc Mater. 2024 04 13;:e2400354

Towards a Light-mediated Gene Therapy for the Eye using Caged Ethinylestradiol and the Inducible Cre/lox System.

Kiy Z, Chaud J, Xu L, Brandhorst E, Kamali T, Vargas C, Keller S, Hong H, Specht A, Cambridge S

Angew Chem Int Ed Engl. 2023 12 21;:e202317675

Photoactivatable Liposomes for Blue to Deep Red Light-Activated Surface Drug Release: Application to Controlled Delivery of the Antitumoral Drug Melphalan.

Brion A, Chaud J, Klimezak M, Bolze F, Ohlmann L, Léonard J, Chassaing S, Frisch B, Kichler A, Heurtault B, Specht A

Bioconjug Chem. 2023 07 1;:

Synthesis and Photochemical Properties of Fluorescent Metabolites Generated from Fluorinated Benzoylmenadiones in Living Cells.

Trometer N, Cichocki B, Chevalier Q, Pécourneau J, Strub JM, Hemmerlin A, Specht A, Davioud-Charvet E, Elhabiri M

J Org Chem. 2023 06 2;:

Wavelength-Dependent, Orthogonal Photoregulation of DNA Liberation for Logic Operations.

Liu LS, Leung HM, Morville C, Chu HC, Tee JY, Specht A, Bolze F, Lo PK

ACS Appl Mater Interfaces. 2022 12 27;:

Red Light-Responsive Upconverting Nanoparticles for Quantitative and Controlled Release of a Coumarin-Based Prodrug.

Brion A, Chaud J, Léonard J, Bolze F, Chassaing S, Frisch B, Heurtault B, Kichler A, Specht A

Adv Healthc Mater. 2022 10 12;:e2201474

Two-Photon Sensitive Coumarinyl Photoremovable Protecting Groups with Rigid Electron-Rich Cycles Obtained by Domino Reactions Initiated by a 5--Dig Cyclocarbopalladation.

Chaud J, Morville C, Bolze F, Garnier D, Chassaing S, Blond G, Specht A

Org Lett. 2021 Sep 10;:

Monitoring of uncaging processes by designing photolytical reactions.

Abou Nakad E, Chaud J, Morville C, Bolze F, Specht A

Photochem. Photobiol. Sci.. 2020 Aug 5;:

Development and Characterization of Layer-by-Layer Coated Liposomes with Poly(L-Lysine) and Poly(L-Glutamic Acid) to Increase their Resistance in Biological Media.

Hermal F, Frisch B, Specht A, Bourel-Bonnet L, Heurtault B

Int J Pharm. 2020 Jun 24;:119568

o-Nitrobenzyl photoremovable groups with fluorescence uncaging reporting properties.

Abou Nakad E, Bolze F, Specht A

Org. Biomol. Chem.. 2018 08 22;16(33):6115-6122

Synthesis and Characterization of Photoactivatable Doxycycline Analogues Bearing Two-Photon-Sensitive Photoremovable Groups Suitable for Light-Induced Gene Expression.

Goegan B, Terzi F, Bolze F, Cambridge S, Specht A

Chembiochem. 2018 06 18;19(12):1341-1348

On the permeation of large organic cations through the pore of ATP-gated P2X receptors.

Harkat M, Peverini L, Cerdan AH, Dunning K, Beudez J, Martz A, Calimet N, Specht A, Cecchini M, Chataigneau T, Grutter T

Proc. Natl. Acad. Sci. U.S.A.. 2017 05 9;114(19):E3786-E3795

Three-Dimensional Control of DNA Hybridization by Orthogonal Two-Color Two-Photon Uncaging.

Fichte MA, Weyel XM, Junek S, Schäfer F, Herbivo C, Goeldner M, Specht A, Wachtveitl J, Heckel A

Angew. Chem. Int. Ed. Engl.. 2016 07 25;55(31):8948-52

Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel.

Habermacher C, Martz A, Calimet N, Lemoine D, Peverini L, Specht A, Cecchini M, Grutter T

Elife. 2016 Jan 25;5:e11050

A Polyurethane-Based Positive Photoresist.

García-Fernández L, Specht A, Del Campo A

Macromol Rapid Commun. 2014 Sep 15;:

The donor-acceptor biphenyl platform: a versatile chromophore for the engineering of highly efficient two-photon sensitive photoremovable protecting groups.

Specht A, Bolze F, Donato L, Herbivo C, Charon S, Warther D, Gug S, Nicoud JF, Goeldner M

Photochem. Photobiol. Sci.. 2012 Mar;11(3):578-86

Live-cell one- and two-photon uncaging of a far-red emitting acridinone fluorophore.

Warther D, Bolze F, Leonard J, Gug S, Specht A, Puliti D, Sun XH, Kessler P, Lutz Y, Vonesch JL, Winsor B, Nicoud JF, Goeldner M

J Am Chem Soc. 2010 Mar 3;132(8):2585-90.

Photolabile glutamate protecting group with high one- and two-photon uncaging efficiencies.

Gug S, Charon S, Specht A, Alarcon K, Ogden D, Zietz B, Léonard J, Haacke S, Bolze F, Nicoud JF, Goeldner M

Chembiochem. 2008 May 23;9(8):1303-7

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