Fiche publication
Date publication
mars 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Dr WAGNER Alain
Tous les auteurs :
Francesco IN, Renier A, Wagner A, Colobert F
Résumé
A convenient synthesis of functionalized propargylic alcohols arising from the 1,2-addition of lithium alkynyl-trimethyl borate onto aldehydes under transition metal free mild conditions is reported. The reaction tolerates a wide range of functional groups, is highly chemoselective and the propargylic alcohols are isolated in good to excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.
Référence
Tetrahedron Lett. 2010 Mar 10;51(10):1386-9
