Pregnancy increases the growth rates of World Health Organization grade II gliomas.

Date publication

mars 2010

Auteurs

Membres identifiés du Cancéropôle Est :
Pr TAILLANDIER Luc

Tous les auteurs :
Pallud J, Mandonnet E, Deroulers C, Fontaine D, Badoual M, Capelle L, Guillet-May F, Page P, Peruzzi P, Jouanneau E, Frenay M, Cartalat-Carel S, Duffau H, Taillandier L

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/20373352

Résumé

Twelve pregnancies in 11 adult women harboring World Health Organization (WHO) grade II gliomas (GIIGs) prior to pregnancy were reviewed to address whether pregnancy affects tumor growth using a quantitative approach of the radiological velocity of diametric expansion (VDE) on successive magnetic resonance images. VDE was significantly increased during pregnancy as compared to prepregnancy (p < 0.001) and to postdelivery (p = 0.012) periods. Pregnancy increases the radiological growth rates of GIIGs. An increase in seizure frequency was observed concomitantly in 40% of cases and further oncological treatment was started after delivery in 25% of cases.

Référence

Ann Neurol. 2010 Mar;67(3):398-404.