Discovery of novel transcriptional and epigenetic targets in APL by global ChIP analyses: Emerging opportunity and challenge.

Date publication

février 2010

Auteurs

Membres identifiés du Cancéropôle Est :
Dr GRONEMEYER Hinrich

Tous les auteurs :
Mikesch JH, Gronemeyer H, So CW

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/20159604

Résumé

Identifying transcriptional program(s) deregulated by oncoproteins is key to understanding the molecular basis of the disease. In this issue of Cancer Cell, two studies by Martens et al. and Wang et al. provide global blueprints for transcriptional targets and epigenetic modifications mediated by PML-RARalpha in acute promyelocytic leukemia.

Référence

Cancer Cell. 2010 Feb 17;17(2):112-4.