Detection of plasma cells, C4d deposits and donor-specific antibodies on sequential graft biopsies of renal transplant recipients with chronic dysfunction.

Date publication

février 2010

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MARTIN Laurent , Dr CHARON-BARRA Céline

Tous les auteurs :
Martin L, Charon-Barra C, Bocrie O, Guignier F, D'Athis P, Dautin G, de la Vega MF, Justrabo E, Rifle G, Mousson C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/19900552

Résumé

BACKGROUND: In order to look for a relationship between humoral mechanisms of rejection and chronic allograft dysfunction, plasma cells, C4d deposits and donor-specific antibodies (DSA) were simultaneously sought on serial biopsies of kidney allograft recipients. PATIENTS AND METHODS: Ten recipients with chronic dysfunction (G1) and 8 recipients with long-term normal graft function (G2) were included. Biopsies and serums were sampled at early graft dysfunction (T1), between 8months and 2years (T2) and after the third year following transplantation (T3). RESULTS: In G1, plasma cells represented 12.3% (T1), 8.2% (T2) and 14.1% (T3) of mononuclear cells. The mean percentage of plasma cells was 11.6% in G1 versus 0.4% in G2 (p

Référence

Transpl Immunol. 2010 Feb;22(3-4):110-4