Health status and quality of life of long-term survivors of childhood acute leukemia: the impact of central nervous system irradiation.

Date publication

mars 2015

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CHASTAGNER Pascal

Tous les auteurs :
Benadiba J, Michel G, Auquier P, Chastagner P, Kanold J, Poiree M, Plantaz D, Padovani L, Berbis J, Barlogis V, Contet A, Chambost H, Sirvent N

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/24936742

Résumé

We evaluated the impact of central nervous system irradiation (CNSI) on long-term health status and quality of life (QoL) of childhood lymphoblastic leukemia survivors included in the French L.E.A. (Childhood and Adolescent Leukemia) multicentric cohort. QoL was self-reported in adults and assessed by parents in children and adolescents, using adapted questionnaires. From 2004 to 2009, 630 nongrafted patients were assessed after 11.8+/-6.3 years from diagnosis. Patients receiving CNSI (18.6%) or chemotherapy alone (81.4%) were compared. The risk of having long-term physical effects was increased with CNSI (odds ratio=3.3; 95% confidence interval, 1.8-5.9), especially regarding growth failure, second tumor, cataract, and overweight. QoL did not differ significantly according to the treatment received, despite a tendency toward lower scores with CNSI in children and adolescents (summary score 63.6+/-13.3 vs. 71.7+/-12.4, P=0.14). Compared with French norms, adult survivors had an impaired QoL, especially in mental domains (mental composite score 45.2+/-9.8 vs. 47.9+/-2.1, P

Référence

J Pediatr Hematol Oncol. 2015 Mar;37(2):109-16