Acute limbic encephalitis and glutamic acid decarboxylase antibodies: a reality?

Date publication

décembre 2009

Auteurs

Membres identifiés du Cancéropôle Est :
Pr NAMER Izzie-Jacques , Pr DE SEZE Jérôme

Tous les auteurs :
Blanc F, Ruppert E, Kleitz C, Valenti MP, Cretin B, Humbel RL, Honnorat J, Namer IJ, Hirsch E, Manning L, de Seze J

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/19786284

Résumé

Limbic encephalitis (LE) associated with glutamic acid decarboxylase antibodies (GAD-Ab) is rare. We describe a 30-year-old male with acute LE and GAD-Ab, with follow-up during 2 years of cognitive status including verbal episodic memory, number of seizures recorded by high-resolution video-EEG, brain MRI, 2-[18F]-fluoro-2-deoxyglucose PET and GAD-Ab titres. Treatment with corticosteroids, IV immunoglobulins, immunosuppressors and antiepileptic drugs resulted in improved memory status, disappearance of seizures and decreased GAD-Ab titres. Review of the other cases of literature and this case is in favour of the existence of autoimmune LE associated with GAD-Ab and supports the link between memory, temporal seizures and possibly GAD-Ab titres.

Référence

J Neurol Sci. 2009 Dec 15;287(1-2):69-71