Late-onset combined immune deficiency: a subset of common variable immunodeficiency with severe T cell defect.

Date publication

novembre 2009

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BONNOTTE Bernard

Tous les auteurs :
Malphettes M, Gerard L, Carmagnat M, Mouillot G, Vince N, Boutboul D, Berezne A, Nove-Josserand R, Lemoing V, Tetu L, Viallard JF, Bonnotte B, Pavic M, Haroche J, Larroche C, Brouet JC, Fermand JP, Rabian C, Fieschi C, Oksenhendler E

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/19807277

Résumé

BACKGROUND: Common variable immunodeficiency (CVID) is a primary immune deficiency defined by defective antibody production. In most series, a small proportion of patients present with opportunistic infections (OIs). METHODS: The French DEFI study has enrolled patients with primary hypogammaglobulinemia and allows a detailed clinical and immunologic description of patients with previous OIs and/or at risk for OIs. RESULTS: Among 313 patients with CVID, 28 patients (8.9%) presented with late-onset combined immune deficiency (LOCID), defined by the occurrence of an OI and/or a CD4(+) T cell count

Référence

Clin Infect Dis. 2009 Nov 1;49(9):1329-38.