Effect of graft source on unrelated donor hemopoietic stem cell transplantation in adults with acute myeloid leukaemia after reduced intensity or non-myeloablative conditioning: a study from the Societe Francaise de Greffe de Moelle et de Therapie Cellula

Date publication

février 2015

Auteurs

Membres identifiés du Cancéropôle Est :
Dr LIOURE Bruno

Tous les auteurs :
Malard F, Milpied N, Blaise D, Chevallier P, Michallet M, Lioure B, Clement L, Hicheri Y, Cordonnier C, Huynh A, Yakoub-Agha I, Peffault de Latour R, Mohty M

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25708220

Résumé

This retrospective report compared the four-year outcomes of allogeneic stem cell transplantation (allo-SCT) in 651 adult patients with acute myeloid leukemia receiving a reduced-intensity or non-myeloablative conditioning (RIC/NMA) regimen according to the type of unrelated donors. These were either umbilical cord blood (UCB, n=205), a 9/10 mismatched unrelated donor (MisMUD, n=99) or a 10/10 matched unrelated donor (MUD, n=347) graft. Neutrophil recovery was slower in UCB (74.5% by day 42) compared to MisMUD (94.8%) and MUD (95.6%) (P

Référence

Biol Blood Marrow Transplant. 2015 Feb 20. pii: S1083-8791(15)00121-4