Significant increase in the apparent incidence of essential thrombocythemia related to new WHO diagnostic criteria: a population-based study.

Date publication

juin 2009

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MAYNADIE Marc

Tous les auteurs :
Girodon F, Bonicelli G, Schaeffer C, Mounier M, Carillo S, Lafon I, Carli PM, Janoray I, Ferrant E, Maynadie M

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/19377078

Résumé

To observe the effect of the new World Health Organization (WHO) criteria on the incidence of myeloproliferative neoplasms, we performed a retrospective study of a population-based registry in the Cote d'Or area, France, from 1980 to 2007. A total of 524 myeloproliferative neoplasms were registered for the 1980-2007 period, including 135 polycythemia vera, 308 essential thrombocythemia and 81 idiopathic myelofibroses. No change in the incidence of either polycythemia vera or idiopathic myelofibrosis was observed for the 2005-2007 period, compared to 1980-2004. On the contrary, a pronounced increase in the incidence of essential thrombocythemia was noted after 2005, mainly due to the use of JAK2 mutation screening and a lower threshold of platelet count. Our study confirms the relevance of the new WHO diagnostic criteria in allowing earlier diagnosis of essential thrombocythemia.

Référence

Haematologica. 2009 Jun;94(6):865-9