Squaraine as a bright, stable and environment-sensitive far-red label for receptor-specific cellular imaging.

Date publication

février 2015

Auteurs

Membres identifiés du Cancéropôle Est :
Pr HIBERT Marcel , Pr MELY Yves

Tous les auteurs :
Karpenko IA, Klymchenko AS, Gioria S, Kreder R, Shulov I, Villa P, Mely Y, Hibert M, Bonnet D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25594279

Résumé

Herein, we show that a far-red arylidene-squaraine dye is stable against nucleophiles, in contrast to arene-squaraines. Owing to the fluorescence enhancement in apolar media together with high brightness and photostability, this dye was successfully applied to detect the oxytocin G protein-coupled receptor and monitor its internalization in living cells.

Référence

Chem Commun (Camb). 2015 Feb 18;51(14):2960-3