Fiche publication
Date publication
février 2009
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BOIREAU Wilfrid
,
Dr PIERALLI Christian
,
Dr WACOGNE Bruno
,
Dr ELIE-CAILLE Céline
Tous les auteurs :
Mangeat T, Berthier A, Elie-Caille C, Perrin M, Boireau W, Pieralli C, Wacogne B
Résumé
We report Gold/Silica biochips for low cost biosensor devices. Firstly, the study of biochemical interactions on silica by means of Surface Plasmon Resonance (SPR) is presented. Secondly, Gold/Silica biochips are employed to reduce the strong quenching that occurs when a fluorophore is close to the gold surface. Furthermore, the control of the Silica-like thickness allows optimizing the distance between the metallic surface and the fluorophore in order to enhance the fluorescent signal. These results represent the first steps towards highly sensitive, specific and low cost biosensors based, for example, on Surface Plasmon Coupled Emission (SPCE) techniques.
Référence
Laser Phys. 2009 Feb;19(2):252-8
