Fiche publication
Date publication
février 2009
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LIZARD Sarab
Tous les auteurs :
Boidot R, Vegran F, Lizard-Nacol S
Lien Pubmed
Résumé
Survivin, a member of the apoptosis inhibitor protein family. is expressed in numerous human tumours, and its expression is described as a negative prognostic marker. Four alternative splice variants (survivin-Delta Ex3, survivin-3B, survivin-2B and survivin-2 alpha) have been described. To date, little is known about the prognostic or predictive role of all five survivin transcripts in breast cancer. In this study, we analysed. by means of real-time quantitative PCR, the five survivin transcripts in a population of 60 breast carcinoma patients treated with 5-fluorouracil + epirubicin + cyclophosphamide (FEC, n=32) or with docetaxel + epirubicin (Tax-Epi, n=28). For each patient, samples were obtained before and after one course of chemotherapy. Before treatment, the ratio of survivin-2 alpha was significantly higher in resistant than in sensitive tumours treated by the FEC regimen (P=0.0161). while the ratio of survivin-Delta Ex3 was higher in sensitive than in resistant samples treated with Tax-Epi (p=0.0234). After one course of chemotherapy, expression of survivin-3B was significantly associated with resistance (p=0.0448) in the FEC treatment group, and the ratios of survivin-Delta Ex3 (p=0.0071) and survivin-2B (p=0.0380) were significantly higher in sensitive than in resistant tumours in the Tax-Epi treatment group. Notably, increased expression and ratio of survivin-3B after one Course of Tax-Epi was associated with reduced disease-free survival (p=0.0299 and 0.0277, respectively) and with reduced overall survival (p=0.0145 and
Référence
Int J Mol Med. 2009 Feb;23(2):285-91.
