[Kappa light chain deposition disease, presenting as Sjogren's syndrome, successfully treated by high-dose melphalan and autologous blood stem transplantation]

Date publication

janvier 2009

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DECONINCK Eric

Tous les auteurs :
Foguem C, Kantelip B, Deconinck E, Hafsaoui C, Meaux-Ruault N, Gil H, Magy-Bertrand N, Dupond JL

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/18801600

Résumé

INTRODUCTION: Light chain deposition disease is a systemic disorder characterised by tissue deposition of monoclonal immunoglobulin light chains without tinctorial properties. It has been exceptionally reported with salivary involvement mimicking Sjogren's syndrome and peripheral neuropathy. CASE REPORT: We report a case of light chain deposition disease associated with plasma cell dyscrasia presenting as sicca syndrome with salivary glands hypertrophy and polyneuropathy successfully treated by high dose melphalan and autologous blood stem transplantation. CONCLUSION: Light chain deposition disease should be recognized as an aetiology of sicca syndrome and peripheral neuropathy. Further studies should assess the prevalence of sicca syndrome in light chain deposition disease and better characterise the neurological manifestations.

Référence

Rev Med Interne. 2009 Jan;30(1):49-52