The intrathoracic lymph node ratio seems to be a better prognostic factor than the level of lymph node involvement in lung metastasectomy of colorectal carcinoma.

Date publication

février 2015

Auteurs

Membres identifiés du Cancéropôle Est :
Pr FALCOZ Pierre-Emmanuel , Pr OLLAND Anne

Tous les auteurs :
Renaud S, Falcoz PE, Olland A, Schaeffer M, Reeb J, Santelmo N, Massard G

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25358477

Résumé

OBJECTIVES: Data on thoracic lymph node involvement (LNI) in lung metastasis of colorectal cancer (CRC) are conflicting, with a 5-year overall survival (OS) ranging from 6 to 40%. We aimed to evaluate whether there are subgroups of patients according to the lymph node ratio (LNR). METHODS: We retrospectively reviewed the data from 106 patients who underwent a thoracic procedure for CRC lung metastasis with pathologically proven thoracic LNI. RESULTS: In the univariate analysis, the median OS was significantly poorer for a pN2 location of LNI (26 vs 16 months, P = 0.04), LNR >/=50% (30 vs 17 months, P = 0.005), high preoperative CEA (32 vs 16 months, P = 0.02), hepatic metastases (27 vs 11 months, P

Référence

Interact Cardiovasc Thorac Surg. 2015 Feb;20(2):215-21