Fiche publication
Date publication
septembre 2008
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GILLET Pierre
Tous les auteurs :
Benani A, Pottie P, Fauchet M, Gossard C, Netter PK, Gillet P, Guingamp C
Résumé
Ligaments are strong hands of connective tissue which display high resistance to tension, allowing joint stability. However, sudden twisting motion and excessive stretching are causes Of sprains. Medical managements involve initial symptomatic treatment and secondary rehabilitation regimen, without beneficial effect regarding the mechanical properties Of the tissue. In fact, ligaments never recover their initial resistance to load tension. lit this article, we reviewed the macroscopic and biochemical characteristics of normal and injured ligaments, with a special emphasis oil the role of cytokines and growth factors during the healing process, and on the beneficial effect of a moderate exercise on the seat-formation. Indeed, recent data highlighted: (1) the role of both IL-1 beta and bFGF during the inflammatory state to promote fibroblast and endothelial cell migration into the Wound; (2) VEGF helped capillary growth during the proliferative state; (3) whereas TGF beta expression resulted in the deposition of a disorganised fibrotic extracellular matrix. In contrast, mechanical stimulation during a moderate exercise inhibited TGF beta expression, improving the deposition of specific collagen network and the overall ligament healing process. (c) 2008 Elsevier Masson SAS. All rights reserved.
Référence
Irbm. 2008 Sep;29(4):267-71
