Fiche publication
Date publication
mai 2008
Auteurs
Membres identifiés du Cancéropôle Est :
Pr AUBIN François
,
Dr GRANEL-BROCARD Florence
,
Pr LIPSKER Dan
Tous les auteurs :
Grange F, Vitry F, Granel-Brocard F, Lipsker D, Aubin F, Hedelin G, Dalac S, Truchetet F, Michel C, Batard ML, Baury B, Halna JM, Schmutz JL, Delvincourt C, Reuter G, Dalle S, Bernard P, Danzon A
Lien Pubmed
Résumé
Objective: To describe current management of cutaneous melanoma (CM) and identify factors accounting for disparities. Design: Retrospective population-based study using survey of cancer registries and pathology laboratories, and questionnaires to physicians. Setting: Five regions covering 19.2% of the French territory and including 8.2 million inhabitants. Patients: Incident cases of patients with stage I to stage II (hereinafter, stage I-II) tumors staged according to the American Joint Committee on Cancer Staging guidelines and nodal stage III CM in 2004. Main Outcome Measures: Modalities of diagnosis and excision, surgical margins, sentinel lymph node biopsy, adjuvant therapies and surveillance procedures, and their variations according to age, sex, residence, location of primary CM, Breslow thickness, type of physicians, modalities of decisions, and health care patterns. Results: Clinical stage I-II CMs(n=710 cases) slightly predominated in females (53%), with a lower mean Breslow thickness (1.4 mm) than in males (1.9 mm). Initial excisions were most often performed by private dermatologists and wide excisions by surgeons. Narrow margins (8%) were associated with advanced age, higher Breslow thickness, and head location. Sentinel lymph node biopsy was performed in 34% of CMs thicker than 1.0 mm, depending on geographical regions, distance from reference centers, and health care patterns. Adjuvant therapies (mainly low-dose interferon) were proposed in 53% of thick CMs (> 1.5 mm), depending on the patient's age and geographical region. In contrast with French recommendations, surveillance procedures frequently included systematic medical imaging. Stage III nodal CMs(n=89 cases) predominated in males (62%). After lymphadenectomy, adjuvant therapies (including high-dose interferon in 32% of cases and chemotherapies in 24% of cases) were proposed in 68% of cases, depending on the patient's age and geographical region. A complete 1-year high-dose interferon regimen was administered in less than 10% of cases. Conclusion: Large disparities still exist in the management of CM in France, depending to a greater extent on medical and geographical environment than on the characteristics of either patients or tumors.
Référence
Arch Dermatol. 2008 May;144(5):629-36.
