Inhibitory effects of trans-resveratrol analogs molecules on the proliferation and the cell cycle progression of human colon tumoral cells.

Date publication

mai 2008

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DELMAS Dominique

Tous les auteurs :
Marel AK, Lizard G, Izard JC, Latruffe N, Delmas D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/18384089

Résumé

Resveratrol may function as a cancer chemopreventive agent. However, few data are available on the antitumoral activities of its dimer, epsilon-viniferin, also present in human diet. So, the effects of resveratrol, epsilon-viniferin, of their acetylated forms (resveratrol triacetate, epsilon-viniferin pentaacetate) and of vineatrol (a wine grape extract) were compared on human adenocarcinoma colon cells. Resveratrol and resveratrol triacetate inhibit cell proliferation and arrest cell cycle. epsilon-Viniferin and epsilon-viniferin pentaacetate slightly reduce cell proliferation. Vineatrol inhibits cell proliferation and favors an accumulation in the S phase of the cell cycle. Consequently, resveratrol triacetate and vineatrol could constitute new putative anticancer agents on colon carcinoma.

Référence

Mol Nutr Food Res. 2008 May;52(5):538-48.