Accumulation of 24S-hydroxycholesterol in neuronal SK-N-BE cells treated with hexacosanoic acid (C26:0): Argument in favor of 24S-hydroxycholesterol as a potential biomarker of neurolipotoxicity.

Date publication

janvier 2015

Auteurs

Membres identifiés du Cancéropôle Est :
Dr LIZARD Gérard

Tous les auteurs :
Zarrouk A, Hammami M, Moreau T, Lizard G

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25577946

Résumé

Cholesterol oxide derivatives (oxysterols) are viewed as potential biomarkers of neurodegenerative diseases. 24S-hydroxycholesterol, an oxysterol produced only in brain neurons, is often found for unknown reasons in increased levels in the plasma in patients with neurodegenerative diseases. On human neuronal SK-N-BE cells treated with hexacosanoic acid (C26:0) identified at increased levels in the tissues and plasma of patients with peroxisomal leukodystrophies and Alzheimer's disease, we observed increased level of 24S-hydroxycholesterol associated with C26:0 induced lipotoxicity. This finding reinforces the hypothesis suggesting that 24S-hydroxycholesterol could constitute a biomarker of neurotoxicity.

Référence

Rev Neurol (Paris). 2015 Jan 8. pii: S0035-3787(14)01073-X