[Case-control study evaluating the incidence of hyperhomocysteinemia in cancer patients in an internal medicine department]

Date publication

août 2007

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BONNOTTE Bernard , Pr GHIRINGHELLI François

Tous les auteurs :
Falvo N, Ghiringhelli F, Berthier S, Bonnotte B, Lorcerie B

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/17537549

Résumé

PURPOSE: Cancer is a cause of venous thromboembolism. However, the physiopathology remains unknown. Hyperhomocysteinemia could be a promoting factor. METHOD: We built a case-control study of 65 patients followed for 2 years to compare levels of homocysteinemie in cancer bearing patients with that in matched cancer free control patients. RESULTS: Fifty per cent of cancer bearing patients had significantly increased blood serum levels of homocysteine (P=0.006). This increase did not correlate with any deficiency in blood serum levels of folate or vitamin B12. CONCLUSION: High levels of homocysteinemie could be linked to tumor proliferation.

Référence

Rev Med Interne. 2007 Aug;28(8):520-5