Fiche publication
Date publication
août 2007
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BRONOWICKI Jean-Pierre
,
Pr GUEANT Jean-Louis
Tous les auteurs :
Alberto JM, Hamelet J, Noll C, Blaise S, Bronowicki JP, Gueant JL, Delabar JM, Janel N
Lien Pubmed
Résumé
Cystathionine beta synthase (CBS) deficiency is a metabolic disorder that is biochemically characterized by severe hyperhomocysteinemia. In order to show the effects of CBS deficiency onto the activity of the enzymes involved in the remethylation pathway, we used the well characterized genetic model of severe hyperhomocysteinemia in mice. We showed that CBS deficiency in mice reduced hepatic methionine synthase and betaine-homocysteine methyltransferase activities, whereas 5,10-methylene tetrahydrofolate reductase activity was increased.
Référence
Mol Genet Metab. 2007 Aug;91(4):396-8
