Fiche publication
Date publication
août 2007
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GIANGRANDE Angela
Tous les auteurs :
Soustelle L, Giangrande A
Lien Pubmed
Résumé
glial cells missing genes (gcm and gcm2) act as the glial fate determinants in the Drosophila embryo. However, their requirement in the adult central nervous system (CNS) is at present not known, except for their role in lamina glia. This is particularly important with respect to two recent sets of data. Adult glial subpopulations differentiate through embryonic glia proliferation. Also, gcm-gcm2 are required for the differentiation of specific adult neurons. We here show that gcm is expressed in precursors and postmitotic, migrating, cells of the medulla neuropile glia (mng) lineage. It is also expressed in a thoracic glial lineage and in neurons of the ventral nerve cord (VNC). Finally, while gcm is required for gliogenesis in medulla and VNC, it does not seem to be required for the generation of VNC neurons.
Référence
Dev Dyn. 2007 Aug;236(8):2101-8.
