Use of amniotic membrane transplantation in the treatment of venous leg ulcers.

Date publication

juillet 2007

Auteurs

Membres identifiés du Cancéropôle Est :
Pr AUBIN François , Pr HUMBERT Philippe

Tous les auteurs :
Mermet I, Pottier N, Sainthillier JM, Malugani C, Cairey-Remonnay S, Maddens S, Riethmuller D, Tiberghien P, Humbert P, Aubin F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/17650088

Résumé

Amniotic membrane (AM), the most internal placental membrane, has unique properties including antiadhesive effects, bacteriostatic, wound protection and pain-reduction properties, as well as epithelialization initialization capacities. Furthermore, AM is widely available and less costly than other bioengineered skin substitutes. In a prospective pilot study, we evaluated the safety, feasibility, and the effects on healing of AM graft in 15 patients with chronic venous leg ulcers. AM grafts were prepared from placentas harvested during cesarean section. All grafted AM had adhered to the wound bed 7 days after being applied with a 100% engraftment rate. The percentage of granulation tissue increased significantly (from 17% on day 0 to 69% on day 14, p

Référence

Wound Repair Regen. 2007 Jul-Aug;15(4):459-64.