Fiche publication
Date publication
mai 2007
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SCHOHN Hervé
Tous les auteurs :
Murad H, Fiatte C, Brunner E, Huin-Schohn C, Schohn H, Becuwe P, Domenjoud L, Dauca M
Lien Pubmed
Résumé
The peroxisome pro liferator-activated receptors (PPARs) are transcription factors and belong to the superfamily of nuclear receptors. They are encoded by three genes located on different chromosomes: PPAR alpha, PPAR(beta/delta and PPAR gamma. PPARa plays a key role in the control of lipid metabolism and homeostasis. PPAR(beta/delta is expressed ubiquitously and participates in skeletal muscle physiology. PPAR(beta/delta and PPAR gamma are important factors for placental development and function as well as for embryo implantation. In addition, PPAR gamma is mainly involved in adipogenesis. PPARs also participate more or less to cell proliferation, differentiation and apoptosis. Surprisingly, the involvement of these transcription factors in cell-cell and/or cell-matrix interactions has not yet been reviewed except for their role as therapeutic agents in inflammation. Nevertheless, several pioneer reports have recently provided some new insights in this research field, by suggesting that PPARs are involved, directly or indirectly, in these interactions and that their activation by specific ligands may lead to potential therapeutic approaches.
Référence
Med Sci (Paris). 2007 May;23(5):515-8.
