Residual stress ischaemia is associated with blood markers of myocardial structural remodelling.

Date publication

avril 2007

Auteurs

Membres identifiés du Cancéropôle Est :
Pr KARCHER Gilles

Tous les auteurs :
Radauceanu A, Moulin F, Djaballah W, Marie PY, Alla F, Dousset B, Virion JM, Capiaumont J, Karcher G, Aliot E, Zannad F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/17140850

Résumé

BACKGROUND: Long-term prognosis of coronary artery disease (CAD) patients is worsened when stress ischemia persists on treatment, but the relationship with adverse cardiac remodelling had never been investigated. AIM: To analyze changes in blood markers of fibrosis in patients with chronic CAD exhibiting exercise ischaemia. METHODS: Circulating markers of collagen: (i) turnover (amino-terminal propeptide of collagen-III [PIIINP]) and (ii) degradation (matrix metalloproteinase 1 [MMP-1]), were obtained in 139 CAD patients referred for exercise 201Tl-SPECT. RESULTS: In the 57 patients who had SPECT-ischaemia, PIIINP was higher (4.3+/-2.9 microg L-1 vs. 3.1+/-1.5 microg L-1, p=0.002) and MMP-1 lower (3.8+/-2.1 microg L-1 vs. 4.7+/-2.8 microg L-1, p=0.04) than in the 82 patients without SPECT-ischaemia. PIIINP was independently related to LV volume, SPECT-ischaemia and age, whereas MMP-1 was related to current treatment with ACEI and beta-blockers (p

Référence

Eur J Heart Fail. 2007 Apr;9(4):370-6