Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability.

Date publication

mars 2007

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CHENARD Marie-Pierre , Dr DOMON-DELL Claire , Dr DULUC Isabelle , Dr FREUND Jean-Noël , Dr GUERIN Eric

Tous les auteurs :
Subtil C, Guerin E, Schneider A, Chenard MP, Martin E, Domon-Dell C, Duluc I, Brabletz T, Kedinger M, Duclos B, Gaub MP, Freund JN

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/16730885

Résumé

The expression of the CDX2 gene, a crucial regulator of gut homeostasis, is altered in human colorectal cancers in parallel with de-differentiation. Here, we have investigated the chromosomal status of CDX2 in human sporadic colorectal cancers with the phenotype of chromosomal instability. Allelic imbalance determination showed frequent rearrangements at the CDX2 locus. The rearrangements correlated with CDX2 gene amplification, as assessed by quantitative PCR analysis. However, they were not predictive of the Cdx2 protein pattern. These data suggest that mechanisms other than structural alterations at the CDX2 locus account for the change of expression in colorectal cancers.

Référence

Cancer Lett. 2007 Mar 18;247(2):197-203