Beta-catenin and ZO-1: shuttle molecules involved in tumor invasion-associated epithelial-mesenchymal transition processes.

Date publication

janvier 2007

Auteurs

Membres identifiés du Cancéropôle Est :
Pr POLETTE Myriam

Tous les auteurs :
Polette M, Mestdagt M, Bindels S, Nawrocki-Raby B, Hunziker W, Foidart JM, Birembaut P, Gilles C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/17587809

Résumé

The cytoplasmic/nuclear relocalization of beta-catenin and ZO-1 from the adherens and tight junctions are common processes of the epithelial-mesenchymal transition (EMT) associated with tumor invasion. Data are now accumulating to demonstrate that these molecules, which shuttle between the plasma membrane and the nucleus or the cytosol, are involved in signaling pathways, and contribute to the regulation of genes such as vimentin or matrix metalloproteinase-14 which are turned on during EMT.

Référence

Cells Tissues Organs. 2007;185(1-3):61-5.