Smoking cessation--but not smoking reduction--improves the annual decline in FEV1 in occupationally exposed workers.

Date publication

août 2006

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MARTINET Yves

Tous les auteurs :
Bohadana AB, Nilsson F, Westin A, Martinet N, Martinet Y

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/16356702

Résumé

INTRODUCTION: Individuals exposed both to cigarette smoke and respiratory pollutants at work incur a greater risk of development of airway hyperresponsiveness (AHR) and accelerated decline in forced expiratory volume in 1 s (FEV1) than that incurred by subjects undergoing each exposure separately. We examined whether smoking cessation or smoking reduction improves AHR and thereby slows down the decline in FEV1 in occupationally exposed workers. METHODS: We examined 165 workers (137 males and 28 females) participating in a smoking cessation programme. Nicotine tablets were used for smoking cessation or smoking reduction. Respiratory symptoms were assessed by questionnaire, FEV1 by spirometry and AHR by methacholine challenge test. At 1 year, subjects were classified into quitters, reducers, or continuing smokers. RESULTS: Sixty-seven subjects completed the study (32 quitters; 17 reducers; 18 continuing smokers). Respiratory symptoms improved markedly in quitters (P

Référence

Respir Med. 2006 Aug;100(8):1423-30