Fiche publication


Date publication

juin 2006

Auteurs

Membres identifiés du Cancéropôle Est :
Pr LAQUERRIERE Patrice


Tous les auteurs :
Grandjean-Laquerriere A, Laquerriere P, Jallot E, Nedelec JM, Guenounou M, Laurent-Maquin D, Phillips TM

Résumé

A possible complication associated with the implantation of hydroxyapatite (HA)-based prosthesis is the release of particles. These particles can be phagocyted by monocytes that are among the first cells to colonize the inflammatory site. The activated monocytes produce inflammatory mediators such as cytokines that cause osteoclasts activation. The present work, describes studies on the effect of sol-gel derived zinc-substituted HA particles with various zinc substitution percentages (0.5-2%) on cytokine production (TNF-alpha, IL-1beta, IL-6, IL-10, and IL-8) by both LPS-stimulated or unstimulated human monocytes. Our data demonstrates that the zinc has an effect on cytokines production. It decreases the production of TNF-alpha and increases the production of IL-8 by unstimulated cells. Using LPS-stimulated cells, it decreases the production of inflammatory cytokines and increases the production of anti-inflammatory cytokine (IL-10), indicating that zinc-substituted hydroxyapatite has favourable effects on the cytokines production by monocytes.

Référence

Biomaterials. 2006 Jun;27(17):3195-200