Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma.

Date publication

avril 2006

Auteurs

Membres identifiés du Cancéropôle Est :
Dr WASYLYK Bohdan

Tous les auteurs :
Muller D, Millon R, Theobald S, Hussenet T, Wasylyk B, du Manoir S, Abecassis J

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/16598186

Résumé

We evaluated the expression and amplification of cyclin L1 (CCNL1) gene, a potential oncogene localised in the commonly amplified 3q25-28 region, in human head and neck squamous cell carcinomas (HNSCCs). Overexpression was observed in 55 out of 96 cases (57%) and amplification in nine out of 35 tumours (26%) with no relationships to the clinico-pathological parameters. The Cyclin L1 antibody we developed labels nuclear speckles in tumour cells compatible with a role for CCNL1 in RNA splicing.

Référence

Br J Cancer. 2006 Apr 10;94(7):1041-4.