Fiche publication
Date publication
janvier 2006
Auteurs
Membres identifiés du Cancéropôle Est :
Dr NUZILLARD Jean-Marc
Tous les auteurs :
Dinoiu V, Tinant B, Nuzillard JM, Bouillon JP
Résumé
The paper presents a one-pot conversion of gamma-keto-alpha-pentafluoroethyl thioester into new pyridazin-3-ones and alpha,beta-unsaturated lactams. The structures of all new compounds were ascribed using 1D (F-19, H-1, C-13) and 2D (H-1-N-15) NMR data, and X-ray diffraction analysis. Two possible competitive reaction mechanisms for the synthesis of pyridazin-3-ones and lactams are presented. (C) 2005 Elsevier B.V. All rights reserved.
Référence
J Fluor Chem. 2006 Jan;127(1):101-7.
