Fiche publication


Date publication

décembre 2005

Auteurs

Membres identifiés du Cancéropôle Est :
Dr PREVOST Alain


Tous les auteurs :
Landais E, El-Khoury V, Prevost A, Dufer J, Liautaud-Roger F

Résumé

Although nicotine has been implicated as a potential factor in the pathogenesis of human cancer, its mechanisms of action regarding cancer development remain largely unknown. HL-60 cells were used to investigate the effects of a short-term treatment with nicotine at concentrations found in the blood of smokers. The findings show that nicotine induces chromatin decondensation, histone H3 acetylation and up-regulation of the c-Jun transcription factor mRNA. This increase is inhibited by mecamylamine, a nicotinic receptor antagonist, suggesting that nicotine alters cellular function directly via nicotinic acetylcholine receptors and may then play a role in cell physiology and tumor promotion.

Référence

Oncol Rep. 2005 Dec;14(6):1553-8.