Allele epsilon 4 of APOE is a stronger predictor of Alzheimer risk in Sicily than in continental South Italy.

Date publication

novembre 2005

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis

Tous les auteurs :
Bosco P, Gueant-Rodriguez RM, Anello G, Spada RS, Romano A, Caraci F, Ferri R, Gueant JL

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/16040191

Résumé

The genotype of apolipoprotein E was examined in 173 sporadic Alzheimer's disease (AD) patients, 132 with late onset (LOAD) and 41 with early onset (EOAD), and in 174 healthy matched controls from Sicily. Despite a low frequency of the epsilon 4 allele (6.3%, 95% CI: 4.2--9.4) in controls, epsilon 4 allele was a stronger predictor of AD risk (odds ratio: 5.8, 95% CI: 3.5--9.4; p

Référence

Neurosci Lett. 2005 Nov 18;388(3):168-72.