A new magnetic resonance imaging contrast agent loaded into poly(lacide-co-glycolide) nanoparticles for long-term detection of tumors.

Date publication

novembre 2014

Auteurs

Membres identifiés du Cancéropôle Est :
Pr HOEFFEL Christine

Tous les auteurs :
Rigaux G, Roullin VG, Cadiou C, Portefaix C, Van Gulick L, Boeuf G, Andry MC, Hoeffel C, Vander Elst L, Laurent S, Muller R, Molinari M, Chuburu F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25325295

Résumé

The incorporation of a lipophilic Gd chelate (GdDO3A-C12) in biocompatible PLGA poly(D, L-lactide-co-glycolide) nanoparticles was explored as an approach to increase the relaxivity of contrast agents for magnetic resonance imaging. By nanoprecipitation, it was possible to obtain PEGylated gadolinium nanoparticles (mean diameter of 155 nm) with high Gd loading (1.1 x 10(4) Gd centers per nanoparticle). The corresponding GdDO3AC12 subset NPs nanoparticles exhibited an enhanced relaxivity (up to sixfold greater than DOTAREM(R) at 40 MHz) because the nanoparticle framework constrained the lipophilic Gd chelate motion and favorably impacted the Gd chelate rotational correlation time. T1-weighted imaging at 3 T on phantoms showed enhanced contrast for the GdDO3AC12 subset NPs. Importantly, Gd chelate leakage was almost nonexistent, which suggested that these GdDO3AC12 subset NPs could be useful for long-term MRI detection.

Référence

Nanotechnology. 2014 Nov 7;25(44):445103