Unprecedented, fully recyclable, solid-supported reagent for the kinetic resolution of racemic amines through enantioselective N-acetylation.

Date publication

juillet 2005

Auteurs

Membres identifiés du Cancéropôle Est :
Dr WAGNER Alain

Tous les auteurs :
Arseniyadis S, Subhash PV, Valleix A, Wagner A, Mioskowski C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/15983657

Résumé

The high-yielding synthesis and application of the first polymer supported reagent for the kinetic resolution (KR) of amines through enantioselective acetylation is described; this new supported chiral reagent allows the KR of primary amines with excellent selectivities at room temperature; moreover, this supported approach is highly efficient as the Merrifield-supported chiral scaffold can be quantitatively recovered and recycled.

Référence

Chem Commun (Camb). 2005 Jul 14;(26):3310-2