[Interpretation of the CA125 kinetics during first line chemotherapy of the ovarian cancer: methodological aspects and characteristic profiles]

Date publication

mars 2002

Auteurs

Membres identifiés du Cancéropôle Est :
Dr COUDERT Bruno , Dr ZANETTA Sylvie

Tous les auteurs :
Riedinger JM, Eche N, Basuyau JP, Daver A, Touzery C, Mayer F, Coudert B, Fargeot P, Chauffert B, de Gislain C, Zanetta S

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/11937443

Résumé

Mathematical analysis of CA125 kinetics during first line chemotherapy allows calculation of various biologic parameters which are powerful indicators of the therapeutic efficiency. The purpose of this study is to present an original method of interpretation of CA125 kinetics based on both CA125 profile and its half-life value. The first part of this study reviews the practical modalities of CA125 kinetics analysis, the methods of calculation of the biologic parameters as well as the guidelines of interpretation. The second part of this work is dedicated to the presentation of CA125 profile characteristics in responders to chemotherapy, partially or totally nonresponders to chemotherapy, tumoral growth under treatment and tumor lysis syndrome.

Référence

Ann Biol Clin (Paris). 2002 Mar-Apr;60(2):183-91.