The Balance Between Cytotoxic T-cell Lymphocytes and Immune Checkpoint Expression in the Prognosis of Colon Tumors.

Date publication

janvier 2018

Journal

Journal of the National Cancer Institute

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GHIRINGHELLI François , Dr GUENOT Dominique , Pr LEPAGE Côme , Dr DERANGERE Valentin

Tous les auteurs :
Marisa L, Svrcek M, Collura A, Becht E, Cervera P, Wanherdrick K, Buhard O, Goloudina A, Jonchère V, Selves J, Milano G, Guenot D, Cohen R, Colas C, Laurent-Puig P, Olschwang S, Lefèvre JH, Parc Y, Boige V, Lepage C, André T, Fléjou JF, Dérangère V, Ghiringhelli F, de Reynies A, Duval A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/28922790

Résumé

Immune checkpoint (ICK) expression might represent a surrogate measure of tumor-infiltrating T cell (CTL) exhaustion and therefore be a more accurate prognostic biomarker for colorectal cancer (CRC) patients than CTL enumeration as measured by the Immunoscore.

Mots clés

Antigens, CD, genetics, B7-H1 Antigen, analysis, Biomarkers, Tumor, genetics, CD8 Antigens, analysis, CTLA-4 Antigen, genetics, Colon, chemistry, Colorectal Neoplasms, chemistry, Female, Gene Expression, Hepatitis A Virus Cellular Receptor 2, genetics, Humans, Inducible T-Cell Co-Stimulator Protein, genetics, Lymphocytes, Tumor-Infiltrating, Male, Microsatellite Instability, Middle Aged, Neoplasm Staging, Prognosis, Programmed Cell Death 1 Ligand 2 Protein, genetics, Programmed Cell Death 1 Receptor, genetics, Retrospective Studies, Survival Rate, T-Lymphocytes, Cytotoxic, Th1 Cells

Référence

J. Natl. Cancer Inst.. 2018 Jan 1;110(1):