Can treatment with Cocculine improve the control of chemotherapy-induced emesis in early breast cancer patients? A randomized, multi-centered, double-blind, placebo-controlled Phase III trial.

Date publication

décembre 2012

Journal

BMC cancer

Auteurs

Membres identifiés du Cancéropôle Est :
Pr PIVOT Xavier

Tous les auteurs :
Pérol D, Provençal J, Hardy-Bessard AC, Coeffic D, Jacquin JP, Agostini C, Bachelot T, Guastalla JP, Pivot X, Martin JP, Bajard A, Ray-Coquard I

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/23244208

Résumé

Chemotherapy induced nausea and vomiting (CINV) remains a major problem that seriously impairs the quality of life (QoL) in cancer patients receiving chemotherapy regimens. Complementary medicines, including homeopathy, are used by many patients with cancer, usually alongside with conventional treatment. A randomized, placebo-controlled Phase III study was conducted to evaluate the efficacy of a complex homeopathic medicine, Cocculine, in the control of CINV in non-metastatic breast cancer patients treated by standard chemotherapy regimens.

Mots clés

Adult, Aged, Antiemetics, therapeutic use, Antineoplastic Agents, adverse effects, Breast Neoplasms, complications, Double-Blind Method, Female, Humans, Middle Aged, Morphinans, therapeutic use, Plant Extracts, therapeutic use, Quality of Life, Vomiting, chemically induced, Young Adult

Référence

BMC Cancer. 2012 Dec;12:603