[The anti-tumor immune response in breast cancer: Update and therapeutic perspectives].

Date publication

février 2017

Journal

Annales de pathologie

Auteurs

Membres identifiés du Cancéropôle Est :
Dr ARNOULD Laurent , Dr COUDERT Bruno , Pr FUMOLEAU Pierre , Pr GHIRINGHELLI François , Dr LADOIRE Sylvain , Dr DESMOULINS Isabelle , Dr DERANGERE Valentin , Dr THIBAUDIN Marion

Tous les auteurs :
Ladoire S, Derangère V, Arnould L, Thibaudin M, Coudert B, Lorgis V, Desmoulins I, Chaix M, Fumoleau P, Ghiringhelli F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/28159406

Résumé

The role of the immune response in breast cancer is now well recognized and increasingly taken in account. The goal of this article is, in the first part, to underline its prognostic impact and to precise the immunosurvelliance, immunoselection and the immunosubversion concepts involved in the control and evasion of breast carcinoma. In the second part, therapeutic strategies for the restauration of anti-tumor immunity are developed. Vaccination strategies and checkpoints inhibitors blockade strategies are discussed as well as the immunogenic death linked to the conventional treatments of breast cancer.

Mots clés

Breast cancer, Cancers du sein, Checkpoints inhibiteurs, Checkpoints inhibitors, Immunogenic death, Immunoselection, Immunosubversion, Immunosurveillance, Immunosélection, Mort immunogène

Référence

Ann Pathol. 2017 Feb;37(1):133-141