Fiche publication
Date publication
juillet 2016
Journal
Biology of the cell
Auteurs
Membres identifiés du Cancéropôle Est :
Dr HERMETET François
,
Pr PRETET Jean-Luc
,
Dr SANDOZ Patrick
Tous les auteurs :
Hermetet F, Jacquin E, Launay S, Gaiffe E, Couturier M, Hirchaud F, Sandoz P, Prétet JL, Mougin C
Lien Pubmed
Résumé
Efficient clearance of apoptotic cells, named efferocytosis, is a fundamental physiological process for tissue development and homeostasis. The contribution of non-professional phagocytes like fibroblasts to efferocytosis has been established, although the underlying mechanisms are not well understood. We recently demonstrated that horizontal DNA transfer can occur through the uptake of apoptotic human papillomavirus-positive cancer cells by human primary fibroblasts leading to their transformation. The aim of this present study was to analyse the cellular and molecular mechanisms that drive the phagocytic activity of human primary fibroblasts in the context of apoptotic cervical cancer cell removal.
Mots clés
Adult, Apoptosis, Female, Fibroblasts, metabolism, HeLa Cells, Humans, Middle Aged, Papillomaviridae, Uterine Cervical Neoplasms, metabolism
Référence
Biol. Cell. 2016 Jul;108(7):189-204
