Determination of intracellular organelles implicated in daunorubicin cytoplasmic sequestration in multidrug-resistant MCF-7 cells using fluorescence microscopy image analysis.

Date publication

janvier 2000

Journal

Cytometry

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MERLIN Jean-Louis

Tous les auteurs :
Bour-Dill C, Gramain MP, Merlin JL, Marchal S, Guillemin F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/10655559

Résumé

Anthracycline resistance is known to be mediated by P-glycoprotein (P-gp) or multidrug-resistance related protein (MRP) as well as intracellular sequestration of drugs.

Mots clés

Antibiotics, Antineoplastic, metabolism, Apoptosis, Cytoplasm, metabolism, Daunorubicin, metabolism, Drug Resistance, Multiple, Golgi Apparatus, metabolism, Humans, Image Processing, Computer-Assisted, methods, Microscopy, Fluorescence, methods, Organelles, metabolism, P-Glycoprotein, biosynthesis, Quality Control, Reproducibility of Results, Subcellular Fractions, Tumor Cells, Cultured, Vault Ribonucleoprotein Particles, biosynthesis

Référence

Cytometry. 2000 Jan;39(1):16-25